Cisplatin-based neoadjuvant therapy has shown clear benefits in clinical stage II or IIIA muscle invasive bladder cancer (MIBC), achieving an impact in progression-free survival and overall survival. This updated review focuses on neoadjuvant therapy for MIBC, including the current recommendations from international and/or local practice guidelines, as well as studies of new therapeutic agents (immunotherapy, targeted therapy), on top of research on potential biomarkers that may predict response to immunotherapy.

Renal cell carcinoma (RCC) is a heterogenous disease which the incidence is increasing worldwide. The identification and understanding of the role of the Von Hipple Lindau (VHP) in regulating the hypoxia-inducible factor signaling pathway has revolutionized the treatment of this disease. Belzutifan is an oral hypoxiainducible factor (HIF)-2α inhibitor, which has demonstrated efficacy in treating von Hippel-Lindau (VHL) disease and for the treatment of adults with RCC who experienced disease progression after PD-1/PD-L1– and VEGFR-targeted therapies. One of the most common adverse effect of this drug is anemia; however, it is treatment is not well known. This review summarizes role of the VHL-HIF pathway in ccRCC aroused the interest of targeting HIF activity, the history of belzutifan development and their relationship to anemia as well as propose a management algorithm

This research paper entitled "Effect of dose of magnesium oxide in the cultivation of cucumber (Cucumis sativus L.) Hybrid EM 160 F1 Hyb American Slicer, in the district of Lamas", was conducted in order to evaluate the effect of four doses of magnesium oxide in the production of culture Gherkin (Cucumis sativus L.), was used for the statistical design of randomized complete block, with three blocks and five treatments, whose variables studied were: number of inflorescence produced by plant, number of fruit per plant, fruit weight, fruit length, fruit diameter, yield frutos.Ha- 1 (kg), fruit yield in Tn.ha-1 and economic analysis. The results obtained in this investigation indicate that treatment T 4 (800 kg ha-1 of magnesium oxide) won the largest and best averages for the variables studied, because that magnesium induced physiological responses that promoted growth, plant development, ...

La presente investigación tuvo como objetivo general el determinar qué relación que existe entre el Clima Organizacional y las Escalas Remunerativas en el Fondo Nacional de Desarrollo Pesquero Año 2016; la población Constituido por 207 trabajadores del Fondo Nacional de Desarrollo Pesquero, comprendidos en los regímenes laborales regulados por el Decreto Legislativo 728 y por el Decreto Legislativo 1057 – CAS, la muestra probabilística consideró 135 trabajadores, en los cuales se ha empleado las variables: Clima Organizacional y Escalas Remunerativas. El método empleado en la investigación fue el hipotético deductivo, esta investigación utilizó para su propósito el diseño no experimental de nivel correlacional, que recogió la información en un período específico, que se desarrolló al aplicar el instrumento: Cuestionario de Clima Organizacional en la escala de Likert...

Objective: To evaluate the clinical characteristics and outcomes of first-line ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) in patients with classical Hodgkin lymphoma treated at a neoplastic disease institute in Lima, Peru. Methods: Retrospective study of previously untreated classical Hodgkin lymphoma diagnosed between 2014 and 2018. All received ABVD days 1 and 15 every 28 days. We described clinical features, objective response rate (ORR), overall survival (OS), and adverse events (AEs) per CTCAE v5.0, and explored associations between clinical variables and response using the chi-square test. Results: A total of 157 patients were included, with a median age of 31.5 years (interquartile range [IQR]: 22–49.25), of whom 56.7% were male. The most common histological type was nodular sclerosis (64.3%). Bulky disease was present in 17.8%, mediastinal mass in 45.2%, and B symp...