Cisplatin-based neoadjuvant therapy has shown clear benefits in clinical stage II or IIIA muscle invasive bladder cancer (MIBC), achieving an impact in progression-free survival and overall survival. This updated review focuses on neoadjuvant therapy for MIBC, including the current recommendations from international and/or local practice guidelines, as well as studies of new therapeutic agents (immunotherapy, targeted therapy), on top of research on potential biomarkers that may predict response to immunotherapy.

Cisplatin-based neoadjuvant therapy has shown clear benefits in clinical stage II or IIIA muscle invasive bladder cancer (MIBC), achieving an impact in progression-free survival and overall survival. This updated review focuses on neoadjuvant therapy for MIBC, including the current recommendations from international and/or local practice guidelines, as well as studies of new therapeutic agents (immunotherapy, targeted therapy), on top of research on potential biomarkers that may predict response to immunotherapy.

This research paper entitled "Effect of dose of magnesium oxide in the cultivation of cucumber (Cucumis sativus L.) Hybrid EM 160 F1 Hyb American Slicer, in the district of Lamas", was conducted in order to evaluate the effect of four doses of magnesium oxide in the production of culture Gherkin (Cucumis sativus L.), was used for the statistical design of randomized complete block, with three blocks and five treatments, whose variables studied were: number of inflorescence produced by plant, number of fruit per plant, fruit weight, fruit length, fruit diameter, yield frutos.Ha- 1 (kg), fruit yield in Tn.ha-1 and economic analysis. The results obtained in this investigation indicate that treatment T 4 (800 kg ha-1 of magnesium oxide) won the largest and best averages for the variables studied, because that magnesium induced physiological responses that promoted growth, plant development, ...

La presente investigación tuvo como objetivo general el determinar qué relación que existe entre el Clima Organizacional y las Escalas Remunerativas en el Fondo Nacional de Desarrollo Pesquero Año 2016; la población Constituido por 207 trabajadores del Fondo Nacional de Desarrollo Pesquero, comprendidos en los regímenes laborales regulados por el Decreto Legislativo 728 y por el Decreto Legislativo 1057 – CAS, la muestra probabilística consideró 135 trabajadores, en los cuales se ha empleado las variables: Clima Organizacional y Escalas Remunerativas. El método empleado en la investigación fue el hipotético deductivo, esta investigación utilizó para su propósito el diseño no experimental de nivel correlacional, que recogió la información en un período específico, que se desarrolló al aplicar el instrumento: Cuestionario de Clima Organizacional en la escala de Likert...