La insulina sigue siendo fundamental para el tratamiento de la diabetes mellitus tipo 1 y la forma más adecuada de tratar la diabetes tipo 2 cuando los agentes orales no logran las metas o si se presentan complicaciones. La investigación científica explora nuevas formas de presentación del fármaco, para tratar de conseguir mejores efectos en el control metabólico. Desde la década de los 40 la presentación de la insulina protamina neutra de Hagedorn NPH ha sido utilizada en forma relativamente exitosa. En la década de los 90 se presentan los análogos de insulina de acción prolongada glargina y detemir con aparentemente mejores posibilidades en su acción. En el presente trabajo se describen revisiones sistemáticas y trabajos primarios que comparan ambas insulinas. Se concluye que no se encontraron diferencias significativas entre el uso de insulina NPH y análogos de insulina ...

nsulin continues to be fundamental for the treatment of diabetes mellitus type 1 and the most appropriate way to treat type 2 diabetes when oral agents do not achieve the goals or if complications occur. Scientific research explores new ways of presenting the drug trying to achieve better effects on metabolic control. Since the 1940s, the presentation of the neutral protamine insulin from Hagedorn NPH has been used relatively successfully. In the 90s, the long-acting insulin analogues glargine and detemir with apparently better possibilities in their action are presented. In the present work, systematic reviews and primary works comparing both insulins are described. It is concluded that no significant differences were found between the use of insulin NPH and insulin analogues glargine and detemir. NPH insulin remains, despite the time, a safe presentation in patients with low risk of hy...

Objetivo. Describir la frecuencia de las características clínicas y factores asociados a morbilidad intrahospitalaria en pacientes con diabetes mellitus tipo 2 (DM2) en un hospital general, el Hospital Nacional Arzobispo Loayza, entre octubre 2012- abril 2013. Material y Métodos. Estudio observacional longitudinal. Se incluyeron 424 pacientes hospitalizados con diagnóstico de DM2. Se aplicó una ficha de recolección de datos. Los datos fueron extraídos de las historias clínicas y transcritos a una ficha de datos y fueron analizados conel programa Stata. Resultados. La frecuencia de hospitalización por DM2 es 9,62%, el grado de instrucción predominante fue secundaria y superior (52,4%) y 11,3% fueron analfabetos. De los hospitalizados, 11,8% debutaron con la enfermedad; 32,3% no usaron ningún tratamiento hipoglicemiante antes de la hospitalización. La principal causa de hospita...

Objetivo. Describir la frecuencia de las características clínicas y factores asociados a morbilidad intrahospitalaria en pacientes con diabetes mellitus tipo 2 (DM2) en un hospital general, el Hospital Nacional Arzobispo Loayza, entre octubre 2012- abril 2013. Material y Métodos. Estudio observacional longitudinal. Se incluyeron 424 pacientes hospitalizados con diagnóstico de DM2. Se aplicó una ficha de recolección de datos. Los datos fueron extraídos de las historias clínicas y transcritos a una ficha de datos y fueron analizados conel programa Stata. Resultados. La frecuencia de hospitalización por DM2 es 9,62%, el grado de instrucción predominante fue secundaria y superior (52,4%) y 11,3% fueron analfabetos. De los hospitalizados, 11,8% debutaron con la enfermedad; 32,3% no usaron ningún tratamiento hipoglicemiante antes de la hospitalización. La principal causa de hospita...

This is the case of a 56 year-old male patient who attended at endocrinology clinic for the study of resistant hypertension and symptomatic recurrent hypokalemia, who underwent surgery with the presumptive diagnosis of adrenal adenoma but the histopathological study showed an unilateral macronodular adrenal hyperplasia.

This is the case of a 56 year-old male patient who attended at endocrinology clinic for the study of resistant hypertension and symptomatic recurrent hypokalemia, who underwent surgery with the presumptive diagnosis of adrenal adenoma but the histopathological study showed an unilateral macronodular adrenal hyperplasia.

ObjeCtive. To determine the prevalence and risk factors of diabetic peripheral neuropathy (DPN) in newly diagnosed patients of diabetes mellitus (DM2) attending Hospital Nacional Arzobispo Loayza (HNAL). Material and MethOds. Prospective, cross-sectional analytical study in patients attending the Endocrinology Service of HNAL, Lima. Inclusion criteria were a recent diagnosis (less than 3 months) of DM2 according to ADA criteria and age ≥18 years old. Patients with gestational diabetes, secondary diabetes, history of non-DPN and those in hyperglycemic crises were excluded. DPN was evaluated using a biothesiometer and was defined as the presence of a vibration perception threshold greater than 25 V in the plantar region of the first toe of at least one of the feet. To describe the characteristics of the population, frequencies and percentages were used for categorical variables, mean and...

ObjeCtive. To determine the prevalence and risk factors of diabetic peripheral neuropathy (DPN) in newly diagnosed patients of diabetes mellitus (DM2) attending Hospital Nacional Arzobispo Loayza (HNAL). Material and MethOds. Prospective, cross-sectional analytical study in patients attending the Endocrinology Service of HNAL, Lima. Inclusion criteria were a recent diagnosis (less than 3 months) of DM2 according to ADA criteria and age ≥18 years old. Patients with gestational diabetes, secondary diabetes, history of non-DPN and those in hyperglycemic crises were excluded. DPN was evaluated using a biothesiometer and was defined as the presence of a vibration perception threshold greater than 25 V in the plantar region of the first toe of at least one of the feet. To describe the characteristics of the population, frequencies and percentages were used for categorical variables, mean and...

The suggestive clinical characteristics of hyperandrogenism are very common problems in women and have been related with excessive androgen production from ovaries, suprarenal glands or both. The most common identifiable cause of androgen excess is the polycystic ovary syndrome. The virilizing tumors are rare. We report the case of a postmenopausal women with virilizing signs and a left anexial mass. Testosterone 4.3ng/mL (0.2-0.95); DHEAS 56ug/dL (35-430); androstenedione: 10ng/ml (0.4-2.7); Cortisol 16ug/dL. Testosterone post dexamethasone suppression test 3.5ng/mL. Ovarian steroid cell tumors secrete great quantities of testosterone or androstenedione and differ from Leydig cell tumors in that they lack crystals of Reinke. Usually, they are benign, but 20% of malignancy has been reported. They can produce different substances. The election treatment is oophorectomy. As in our p...