Resultados de Búsqueda por Autor

1

artículo

O uso de conectores: análise de erros baseada em corpus de aprendizes de espanhol de língua sinofalante

Publicado por
Yang, Qin

Publicado 2023

El objetivo del trabajo es descubrir los errores frecuentes y específicos de los aprendientes sinohablantes de español como lengua extranjera cuando usan conectores discursivos en los textos escritos. Para ello, se consideran los fundamentos metodológicos del análisis de corpus de aprendices desarrollado por Ramos (2016), así como el análisis de errores de Corder (1971). Los resultados cuantifican los errores y presentan una clasificación de estos, a la vez que ofrecen un principio de explicación de los mecanismos que propician su producción. De esta manera, los resultados pueden ser de utilidad para anticipar las dificultades que presentan los estudiantes; asimismo, permitiría diseñar una implantación didáctica y producir un material adaptado a ellos.

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Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for HER2-negative advanced gastric cancer (KEYNOTE-859): a multicentre, randomised, double-blind, phase 3 trial

Publicado por
Rha, SY, Oh, DY, Yañez, P, Bai, Y, Ryu, MH, Lee, J, Rivera, F, Alves, GV, Garrido, M, Shiu, KK, Fernández, MG, Li, J, Lowery, MA, Çil, T, Cruz, FM, Qin, S, Luo, S, Pan, H, Wainberg, ZA, Yin, L, Bordia, S, Bhagia, P, Wyrwicz, LS, KEYNOTE-859 investigators, Castro-Oliden, V

Publicado 2023

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Background: PD-1 inhibitors combined with chemotherapy have shown efficacy in gastric or gastro-esophageal junction cancer. We compared the efficacy and safety of pembrolizumab plus chemotherapy with placebo plus chemotherapy in participants with locally advanced or metastatic HER2-negative gastric or gastro-esophageal junction adenocarcinoma. Methods: KEYNOTE-859 is a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial, done at 207 medical centres across 33 countries. Eligible participants were aged 18 years and older with previously untreated histologically or cytologically confirmed locally advanced or metastatic HER2-negative gastric or gastro-esophageal junction adenocarcinoma and an Eastern Cooperative Oncology Group performance status of 0 or 1. Patients were randomly assigned (1:1) to receive pembrolizumab or placebo 200 mg, administered intravenously every 3...

3

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Shared genetic architecture of posttraumatic stress disorder with cardiovascular imaging, risk, and diagnoses

Publicado por
Shen, Jie, Valentim, Wander, Friligkou, Eleni, Overstreet, Cassie, Choi, Karmel W., Koller, Dora, O’Donnell, Christopher J., Stein, Murray B., Gelernter, Joel, Koenen, Karestan C., Ressler, Kerry J., Zwart, John Anker, Zoellner, Lori A., Zhao, Hongyu, Zervas, Mark, Zai, Gwyneth C., Zai, Clement C., Young, Keith A., Young, Ross Mc D., Yehuda, Rachel, Xiong, Ying, Xia, Yan, Wolf, Christiane, Wolf, Erika J., Winternitz, Sherry, Winsvold, Bendik S., Williamson, Douglas E., Williams, Michelle A., Werge, Thomas, Wendt, Frank R., Weber, Heike, Waszczuk, Monika, Wang, Yunpeng, Wang, Zhewu, Voisey, Joanne, Vinkers, Christiaan H., Vermetten, Eric, van Rooij, Sanne J.H., Van Hooff, Miranda, van den Heuvel, Leigh Luella, Valdimarsdóttir, Unnur, Ursano, Robert J., Uddin, Monica, Trapido, Edward, Tiwari, Arun K., Thompson, Wesley K., Teicher, Martin H., Sumner, Jennifer A., Stevens, Jennifer S., Stensland, Synne, Stein, Dan J., Sponheim, Scott R., Smoller, Jordan W., Smith, Alicia K., Silove, Derrick, Sheerin, Christina M., Shabalin, Andrey, Seng, Julia S., Seedat, Soraya, Seah, Carina, Santoro, Marcos, Sanchez, Sixto E., Sampson, Laura, Salum, Giovanni Abrahão, de Viteri, Stacey Saenz, Rutten, Bart P.F., Runz, Heiko, Rung, Ariane, Ruggiero, Kenneth J., Roy-Byrne, Peter, Rothbaum, Alex O., Rothbaum, Barbara O., Roberts, Andrea L., Risbrough, Victoria B., Ratanatharathorn, Andrew, Qin, Xue Jun, Powers, Abigail, Porjesz, Bernice, Polusny, Melissa A., Pietrzak, Robert H., Peverill, Matthew, Peterson, Alan L., Peters, Edward S., Panizzon, Matthew S., Pan, Pedro M., Orcutt, Holly K., O’Donnell, Meaghan, Nugent, Nicole R., Norman, Sonya B., Nordentoft, Merete, Nelson, Elliot C., Mufford, Mary S., Mortensen, Preben Bo, Mors, Ole, Morris, Charles Phillip, Morey, Rajendra A., Miller, Mark W., Milberg, William, Milani, Lili, Mikita, Elizabeth A.

Publicado 2025

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Patients with post-traumatic stress disorder face increased cardiovascular risk. This study examines shared genetic regions between post-traumatic stress disorder and 246 cardiovascular conditions across electronic health records, 82 cardiac imaging, and health behaviors defined by Life’s Essential 8. Post-traumatic stress disorder is genetically correlated with cardiovascular diagnoses in 33 regions, imaging traits in 4 regions, and health behaviors in 44 regions. Potentially shared causal variants between post-traumatic stress disorder and 17 cardiovascular conditions were observed in 11 regions. Subsequent observational analysis in AllofUS cohort showed post-traumatic stress disorder is associated with 13 diagnoses even after accounting for socioeconomic factors and depression. Genetically regulated proteome expression in brain and blood tissues identified 33 blood and 122 brain gen...

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Potential causal association between gut microbiome and posttraumatic stress disorder

Publicado por
He, Qiang, Wang, Wenjing, Xu, Dingkang, Xiong, Yang, Tao, Chuanyuan, You, Chao, Ma, Lu, Ma, Junpeng, Nievergelt, Caroline M., Maihofer, Adam X., Klengel, Torsten, Atkinson, Elizabeth G., Chen, Chia Yen, Choi, Karmel W., Coleman, Jonathan R.I., Dalvie, Shareefa, Duncan, Laramie E., Logue, Mark W., Provost, Allison C., Ratanatharathorn, Andrew, Stein, Murray B., Torres, Katy, Aiello, Allison E., Almli, Lynn M., Amstadter, Ananda B., Andersen, Søren B., Andreassen, Ole A., Arbisi, Paul A., Ashley-Koch, Allison E., Austin, S. Bryn, Avdibegovic, Esmina, Babić, Dragan, Bækvad-Hansen, Marie, Baker, Dewleen G., Beckham, Jean C., Bierut, Laura J., Bisson, Jonathan I., Boks, Marco P., Bolger, Elizabeth A., Børglum, Anders D., Bradley, Bekh, Brashear, Megan, Breen, Gerome, Bryant, Richard A., Bustamante, Angela C., Bybjerg-Grauholm, Jonas, Calabrese, Joseph R., Caldas-de-Almeida, José M., Dale, Anders M., Daly, Mark J., Daskalakis, Nikolaos P., Deckert, Jürgen, Delahanty, Douglas L., Dennis, Michelle F., Disner, Seth G., Domschke, Katharina, Dzubur-Kulenovic, Alma, Erbes, Christopher R., Evans, Alexandra, Farrer, Lindsay A., Feeny, Norah C., Flory, Janine D., Forbes, David, Franz, Carol E., Galea, Sandro, Garrett, Melanie E., Gelaye, Bizu, Gelernter, Joel, Geuze, Elbert, Gillespie, Charles, Uka, Aferdita Goci, Gordon, Scott D., Guffanti, Guia, Hammamieh, Rasha, Harnal, Supriya, Hauser, Michael A., Heath, Andrew C., Hemmings, Sian M.J., Hougaard, David Michael, Jakovljevic, Miro, Jett, Marti, Johnson, Eric Otto, Jones, Ian, Jovanovic, Tanja, Qin, Xue Jun, Junglen, Angela G., Karstoft, Karen Inge, Kaufman, Milissa L., Kessler, Ronald C., Khan, Alaptagin, Kimbrel, Nathan A., King, Anthony P., Koen, Nastassja, Kranzler, Henry R., Kremen, William S., Lawford, Bruce R., Lebois, Lauren A.M., Lewis, Catrin E., Linnstaedt, Sarah D., Lori, Adriana

Publicado 2024

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Background: The causal effects of gut microbiome and the development of posttraumatic stress disorder (PTSD) are still unknown. This study aimed to clarify their potential causal association using mendelian randomization (MR). Methods: The summary-level statistics for gut microbiome were retrieved from a genome-wide association study (GWAS) of the MiBioGen consortium. As to PTSD, the Freeze 2 datasets were originated from the Psychiatric Genomics Consortium Posttraumatic Stress Disorder Working Group (PGC-PTSD), and the replicated datasets were obtained from FinnGen consortium. Single nucleotide polymorphisms meeting MR assumptions were selected as instrumental variables. The inverse variance weighting (IVW) method was employed as the main approach, supplemented by sensitivity analyses to evaluate potential pleiotropy and heterogeneity and ensure the robustness of the MR results. We also...

5

artículo

Enhancing discovery of genetic variants for posttraumatic stress disorder through integration of quantitative phenotypes and trauma exposure information

Publicado por
Maihofer, Adam X., Choi, Karmel W., Coleman, Jonathan R.I., Daskalakis, Nikolaos P., Denckla, Christy A., Ketema, Elizabeth, Morey, Rajendra A., Polimanti, Renato, Ratanatharathorn, Andrew, Torres, Katy, Wingo, Aliza P., Zai, Clement C., Aiello, Allison E., Almli, Lynn M., Amstadter, Ananda B., Andersen, Soren B., Andreassen, Ole A., Arbisi, Paul A., Ashley-Koch, Allison E., Austin, S. Bryn, Avdibegović, Esmina, Borglum, Anders D., Babić, Dragan, Bækvad-Hansen, Marie, Baker, Dewleen G., Beckham, Jean C., Bierut, Laura J., Bisson, Jonathan I., Boks, Marco P., Bolger, Elizabeth A., Bradley, Bekh, Brashear, Meghan, Breen, Gerome, Bryant, Richard A., Bustamante, Angela C., Bybjerg-Grauholm, Jonas, Calabrese, Joseph R., Caldas-de-Almeida, José M., Chen, Chia Yen, Dale, Anders M., Dalvie, Shareefa, Deckert, Jürgen, Delahanty, Douglas L., Dennis, Michelle F., Disner, Seth G., Domschke, Katharina, Duncan, Laramie E., Džubur Kulenović, Alma, Erbes, Christopher R., Evans, Alexandra, Farrer, Lindsay A., Feeny, Norah C., Flory, Janine D., Forbes, David, Franz, Carol E., Galea, Sandro, Garrett, Melanie E., Gautam, Aarti, Gelaye, Bizu, Gelernter, Joel, Geuze, Elbert, Gillespie, Charles F., Goçi, Aferdita, Gordon, Scott D., Guffanti, Guia, Hammamieh, Rasha, Hauser, Michael A., Heath, Andrew C., Hemmings, Sian M.J., Hougaard, David Michael, Jakovljević, Miro, Jett, Marti, Johnson, Eric Otto, Jones, Ian, Jovanovic, Tanja, Qin, Xue Jun, Karstoft, Karen Inge, Kaufman, Milissa L., Kessler, Ronald C., Khan, Alaptagin, Kimbrel, Nathan A., King, Anthony P., Koen, Nastassja, Kranzler, Henry R., Kremen, William S., Lawford, Bruce R., Lebois, Lauren A.M., Lewis, Catrin, Liberzon, Israel, Linnstaedt, Sarah D., Logue, Mark W., Lori, Adriana, Lugonja, Božo, Luykx, Jurjen J., Lyons, Michael J., Maples-Keller, Jessica L., Marmar, Charles, Martin, Nicholas G., Maurer, Douglas, Mavissakalian, Matig R.

Publicado 2022

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Background: Posttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD phenotype measurement and incorporation of lifetime trauma exposure (LTE) information could enhance the discovery power of PTSD genome-wide association studies (GWASs). Methods: A GWAS on PTSD symptoms was performed in 51 cohorts followed by a fixed-effects meta-analysis (N = 182,199 European ancestry participants). A GWAS of LTE burden was performed in the UK Biobank cohort (N = 132,988). Genetic correlations were evaluated with linkage disequilibrium score regression. Multivariate analysis was performed using Multi-Trait Analysis of GWAS. Functional mapping and annotation of leading loci was performed with FUMA. Replication was evaluated using the Million Veteran Program GWAS of PTSD total symptoms. Results: GW...