Mr Editor Infection at the operating site (ISO) is the most common postoperative surgical complication in general surgery. This is more frequent in cases of emergency interventions, compromises the patient's prognosis, causes high health costs, and signicantly increases the risk of reintervention. Negative pressure therapy (NPT) is an innovative strategy that was proposed about two decades ago, and has been gradually replicated around the world. This means that there are still many gaps in the evidence when it is used in many diseases and under different contexts. Nevertheless, it allows obtaining conclusive results in the time of healing, reduction of complications (mainly dehiscence and ISO), decrease in hospital stay, among other factors. In Latin America, there is very little evidence on the use of this strategy, and it is null regarding its use in emergency cases without being able ...

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The Duffy protein, a transmembrane molecule, functions as a receptor for various chemokines and facilitates attachment between the reticulocyte and the Plasmodium Duffy antigen-binding protein. Duffy expression correlates with the Duffy receptor gene for the chemokine, located on chromosome 1, and exhibits geographical variability worldwide. Traditionally, researchers have described the Duffy negative genotype as a protective factor against Plasmodium vivax infection. However, recent studies suggest that this microorganism’s evolution could potentially diminish this protective effect. Nevertheless, there is currently insufficient global data to demonstrate this phenomenon. This study aimed to evaluate the relationship between the Duffy genotype/phenotype and the prevalence of P. vivax infection. The protocol for the systematic review was registered in PROSPERO as CRD42022353427 and inv...

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Cardiovascular risk and diseases among patients recovered from COVID-19 is a recent field of study in the world medical literature and is also of vital importance because a large number of patients develop complications once the acute phase of the disease is over. The broad spectrum of myocardial injury in cardiovascular diseases can range from theasymptomatic elevation of cardiac troponin levels to the development of fulminant myocarditis and/or circulatory shock, which can leave significant sequelae. Despite the fact that there is no clear strategy to treat cardiac events that occur during COVID-19 infection and taking into account that treatment is mainly aimed at relieving patients’ symptoms as they arise, the objective of this work was to find out and collect current evidence on this subject, so that readers can be offered a reference guide in Spanish that contributes to the devel...

La epidermólisis bullosa distrófica recesiva, es un trastorno genético heterogéneo severo causado por mutaciones en la expresión de proteínas dérmicas, generando manifestaciones mecano-bullosas. En Latinoamérica, puede ser considerada una línea de investigación de interés que puede ser impulsada y desarrollada por medio de investigación clínica y traslacional en dermatología.

En la actualidad, no exista evidencia del más alto nivel ni detallada sobre este tipo de interacciones, probablemente se deba a las diferencias genéticas y epigenéticas de la población donde se utilice. Tampoco existe mucha literatura relacionada a la descripción precisa de los mecanismos celulares o moleculares asociados a este tipo de interacciones; solamente la evidencia clínica.

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The elderly, often frail, are patients susceptible to numerous complications, both immediate and in the short, medium and long term, following surgical interventions. Depending on their comorbidities, a comprehensive approach should be taken to achieve the best condition of the organs prior to surgery and attempt to maintain it during and after the intervention. Considering the statistical strength of negative outcomes, specifically mortality in elderly patients undergoing major surgery, is truly a challenge. This even extends to other fields such as bioethics, raising a dilemma about dysthanasia when resorting to certain risky interventions in those with a fearful life prognosis. Recently, interesting evidence estimating the incidence, mortality risk and factors associated with negative outcomes in elderly patients undergoing major surgery has been published, suggesting possible modific...

Breast cancer remains the most common malignant neoplasm and one of the leading causes of mortality in women, making it a significant target for global health efforts and a public health priority. Through the use of innovative therapies, survival rates have improved, leading to the emergence of associated conditions such as genitourinary menopausal syndrome. Hormonal therapy is employed for managing this condition, significantly alleviating its symptoms and, in some cases, serving as the sole solution. The most commonly utilized approach is vaginal estrogen therapy. Nevertheless, there have been reports of a potential risk of breast cancer recurrence associated with its use. In the Spanish-speaking context, there is limited evidence discussing this topic. A search was conducted across PubMed, ScienceDirect, and MEDLINE databases, using the terms "Vaginal Estrogen Therapy," "Recurrence," ...

Lung cancer constitutes the main cause of years of life lost due to cancer, being one of the most frequent and the one that generates more deaths annually in the world. Physical training prior to surgery for this cancer has shown the potential to be beneficial for patients undergoing this type of intervention. However, the evidence is heterogeneous and inconclusive. Objective: To evaluate the most recent evidence on preoperative physical training and its benefit on outcomes in lung cancer surgery. Methods: Narrative literature review where PubMed, ScienceDirect, Web of Science, and MEDLINE databases were consulted. Results: Based on the most recent evidence and compared with standard care control groups, preoperative physical training may promote both functional and surgical postoperative outcomes, especially in terms of any complications, pulmonary or severe, as well as hospital stay, f...

Objective: To assess the five- and ten-year cardiovascular disease risk in HIV-positive patients on antiretroviral therapy, using the Framingham risk score and the Data collection on adverse effects of anti-HIV drugs (D:A:D) study. Materials and methods: An observational prospective cross-sectional study. HIV-positive patients on antiretroviral treatment from a referral center for HIV patients were included in the study between January 1 and April 30, 2019. A five- and ten-year cardiovascular risk assessment was performed using the Framingham risk score and the D:A:D study. Additionally, both risk models were compared through statistical models. Results: The study population consisted of 159 patients with a mean age of 48.90 years ± 9.90. The mean cardiovascular risk according to the five-year Framingham risk score was 2.70 % ± 2.80, the ten-year Framingham risk score was 6.10 % ± 5.7...

Las enfermedades cardiovasculares, siguen siendo la principal causa de morbilidad, mortalidad y carga de enfermedad en el mundo. La falla cardiaca, es uno de los fenotipos de enfermedad cardiovascular más prevalentes del mundo, describiéndose más de 60 millones de casos a nivel global. Puntualmente, los diuréticos tiazídicos son un grupo farmacológico importante y de común uso, para la sobrecarga de volumen en el manejo de la falla cardiaca, así como de la hipertensión arterial. Sin embargo, muy recientemente, evidencia novedosa, resalta la presencia de un evento adverso importante en el uso de los diuréticos tiazídicos para el manejo de la falla cardiaca, sobre todo de tipo descompensada. El objetivo de esta revisión consiste en analizar la evolución de la evidencia sobre la seguridad y eficacia de los diuréticos tiazídicos en el abordaje de la falla cardiaca. Se ejecutó...

Objetivo: Analizar la evolución científica de la investigación del linfoma anaplásico de células grandes asociado a implantes mamarios (LACG-AIM) en Latinoamérica, en los últimos 10 años.  Metodología: estudio bibliométrico de corte transversal, que utilizó Scopus, como fuente de datos para este análisis. Se realizó la descripción y caracterización de tendencias y patrones en investigación, así como cálculos de métricas e impacto en investigación. Resultados: Se incluyeron 46 documentos, quienes cumplieron los criterios de inclusión, representando la ventana de tiempo entre 2014 y 2023. Del total de documentos, el 41,3% (n=19) correspondieron a artículos originales, seguido de un 23,9% (n=11) de correspondencias. La tasa del crecimiento anual fue del 24,14%. Se evidenció que, aproximadamente el 82% del total de autores, ha publicado un solo artículo. Brasil lider...

Objective. To visually and bibliometrically analyze Latin  American research on heart failure in the last 20 years. Materials and methods. A bibliometric study using the Scopus database. A non-systematic search was carried out to collect data, which were analyzed using  Bibliometrix, a tool of the R programming language. Results. A total of 10204 documents were included in a period between 2003 to 2023. Of these, 66.9% (n=6824) corresponded to original articles, followed by review articles (15.5%; n=1583). International collaboration was present in 38.41% (n=3919) of the articles. Brazil stood out with the highest number of prolific authors and institutions (70% and 60%, respectively), consolidating its position as leader in the  region, followed by Argentina and Mexico. These countries also presented the papers with the highest impact and most outstanding metrics. Conclusions. This s...

Objective. To visually and bibliometrically analyze Latin  American research on heart failure in the last 20 years. Materials and methods. A bibliometric study using the Scopus database. A non-systematic search was carried out to collect data, which were analyzed using  Bibliometrix, a tool of the R programming language. Results. A total of 10204 documents were included in a period between 2003 to 2023. Of these, 66.9% (n=6824) corresponded to original articles, followed by review articles (15.5%; n=1583). International collaboration was present in 38.41% (n=3919) of the articles. Brazil stood out with the highest number of prolific authors and institutions (70% and 60%, respectively), consolidating its position as leader in the  region, followed by Argentina and Mexico. These countries also presented the papers with the highest impact and most outstanding metrics. Conclusions. This s...

Introduction: Breast cancer remains one of the most prevalent cancers globally, specifically the most common in females. The use of artificial intelligence promises to contribute to early diagnosis through imaging. Previously, the landscape and evolution of this scientific production have not been described. Methods: Cross-sectional bibliometric study using Scopus as the data source. The bibliometrix package in R was employed for calculating bibliometric indicators and visualizing the results. Results: 1292 documents published between 1989 and 2024 were selected. 75.3% (n=973) were articles with primary data, followed by 16.2% (n=209) corresponding to reviews. An international collaboration rate of 26.5% was identified, with an annual production growth of 10.78%. It was observed that risk classification through screening, digital breast tomosynthesis, transfer learning, segmentation, and...

Objective: To analyze the scientific evolution of botulinum toxin usage in plastic surgery in Latin America. Materials and methods: A cross-sectional bibliometric study was conducted using Scopus as the data source. Visual and bibliometric analyses were performed, and metrics were generated to evaluate the evolution, general characteristics and impact of the Latin American evidence on the use of botulinum toxin in plastic surgery. The bibliometrix R-package was utilized for this analysis. Results: The study included 34 documents published between 2002 and 2023, out of which 70.5 % (n = 24) were original articles and 23.5 % (n = 8) were reviews. International collaboration was identified in 32.3 % of the cases. The four most prolific authors were from Colombia and Brazil, each having published only two documents. Brazil (n = 20) was the most prolific country, followed by Chile (n = 5), Ar...