Background: The clinical course of Pick´s disease (PD) is similar to that of Alzheimer´s disease (AD). Clinical cases: We present the clinical course and CT-scan findings in 3 patients (two sporadic cases and one familial case) diagnosed with PD. Results: The course of this disease was characterized by the following: 1) behavioral and personality changes; 2) progressive impairment of recent memory; 3) sex disturbances and /or appetite increase; 4) upper cortex dysfunction; 5) motor, sensorial and sphincter control worsening, and 6) posture and gait impairment, as well as prostration. Brain tomography studies demonstrated atherosclerosis at the supraclinoid segment of carotid arteries and its branches, and also moderate or severe atrophy in both prefrontal and anterior temporal lobes. Conclusions: These findings suggest that PD is also caused by progressive ischemia in the intra-parench...

Antecedentes: El curso clínico de la enfermedad de Pick (EP) es similar a la enfermedad de Alzheimer (EA). Casos clínicos: Presentamos el curso clínico y los hallazgos tomográficos en 3 pacientes (dos casos esporádicos y un caso familiar) con diagnóstico de EP. Resultados: El curso de esta enfermedad estuvo caracterizado por:1) cambios de conducta y personalidad, 2) deterioro progresivo de la memoria reciente, 3) disturbios sexuales y/o aumento del apetito, 4) disfunción cortical superior, 5) empeoramiento motor, sensitivo y esfinteriano, y 6) deterioro de la postura, marcha y postración. Los estudios tomográficos demostraron aterosclerosis en las carótidas supraclínoideas y sus ramas, así como atrofia moderada o severa en los lóbulos prefrontales y temporales anteriores. Conclusiones: Estos hallazgos sugieren que la EP es también causada por isquemia progresiva en el terri...

Clinical case: A 26-year old woman had a 6-month history of motor and sensorial loss in her right foot and leg after undergoing a hip replacement surgery. Two electro-diagnostic studies revealed absence of nerve conduction in tibial, fibular, and sciatic nerves. Six moths afterwards, the patient underwent an omental transplantation in the damaged area of the right sciatic nerve. Results: Neurological improvement occurred from the second day after surgery. Nowadays, two years after surgery, the patient has mild to moderate paralysis and hypoesthesia in her right foot and leg. The patient is able to walk using orthopedic support. Conclusion: These results indicate that with this surgical approach we may be able to get over the sequels caused by ischemia and/or trauma in the sciatic nerve; and probably this may also apply to the brachial plexus.

Clinical case: A 26-year old woman had a 6-month history of motor and sensorial loss in her right foot and leg after undergoing a hip replacement surgery. Two electro-diagnostic studies revealed absence of nerve conduction in tibial, fibular, and sciatic nerves. Six moths afterwards, the patient underwent an omental transplantation in the damaged area of the right sciatic nerve. Results: Neurological improvement occurred from the second day after surgery. Nowadays, two years after surgery, the patient has mild to moderate paralysis and hypoesthesia in her right foot and leg. The patient is able to walk using orthopedic support. Conclusion: These results indicate that with this surgical approach we may be able to get over the sequels caused by ischemia and/or trauma in the sciatic nerve; and probably this may also apply to the brachial plexus.