Background: Mixed reality (MR), a combination of augmented reality (AR) and virtual reality (VR), has emerged as a key tool in surgical mechatronics, improving precision and visualization in clinical procedures. Methods: This study presents a literature review of recent MR advances from the Scopus database, taking into account its impact on surgery and medical education. Technologies such as Microsoft HoloLens and Magic Leap, as well as neurosurgery and orthopedic simulators, are reviewed. Results: MR enhances surgical precision and reduces operating times, with an average decrease from 121.34 to 97.62 minutes. Despite its potential, challenges include discomfort from prolonged device use and low battery autonomy. Conclusions: MR has the potential to transform surgery and medical education; however, its widespread adoption will depend on overcoming technological and financial barr...