Objective: To describe the clinical characteristics of drug-induced liver injury (DILI) in multidrug-resistant tuberculosis (MDR-TB) patients.Materials and methods: A retrospective study conducted in hospitalized patients with MDR-TB and DILI. The criteria of the DILI Expert Working Group were used for the diagnosis of DILI, and the RUCAM (Roussel Uclaf Causality AssessmentMethod) for the causality analysis. The specific association between DILI and antitubercular drugs was established by drug rechallenge or discontinuation and recovery. Results: Seven cases of MDR-TB and DILI are described in this research. The mean age (standard deviation) was 39.10 (3.30) years.Mean DILI occurred 30.40 (27.70) days after starting the treatment. Three (43.00 %) patients presented jaundice. Regarding the type of injury, four (57.00 %) had hepatocellular injury and three (43.00 %) cholestatic injury. Fou...

Introducción: El gen de la N-acetiltransferasa 2 (NAT2) ha sido ampliamente estudiado por su asociación con la Injuria hepática inducida por medicamentos causada por fármacos antituberculosos. El objetivo del presente estudio es evaluar la asociación entre seis polimorfismos del gen NAT2 y la Injuria hepática inducida por pirazinamida (IHIP) en pacientes peruanos. Material y métodos: La asociación específica con IHIP se determinó mediante procesos como reexposición, suspensión y recuperación. Se estudiaron seis polimorfismos del gen NAT2: rs1799929 (c.481C>T), rs1799930 (c.590G>A), rs1799931 (c.857G>A), rs1041983 (c.282C>T), rs1801280 (c.341T>C) y rs1208 (c.802G>A). Resultados: Se incluyeron en el estudio cuarenta pacientes (10 casos y 30 controles) con tuberculosis. Para el polimorfismo rs1041983 (c.282C>T), la razón de probabilidades (OR) fue de 3,7 (...