323-2010-CONCYTEC-OAJ

This work was partially funded by the AECID (Agencia Española de Cooperación Internacional para el Desarrollo) grant numbers A/3795/05, A/4892/06, A/9727/07 A/4817/06; ACCD (Agència Catalana de Cooperació al Desenvolupament, Generalitat de Catalunya) grant U2006; CCD-UPC (Centre de Cooperació per al Desenvolupament, Universitat Politècnica de Catalunya) to LJdV; and by the CONCYTEC (Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica, Perú) grant 189-2005-CONCYTEC-OAJ. JR's research is supported by grant CP05/0130 of the FIS (Fondo de Investigaciones Sanitarias). The authors thank M.J. Pons and Donna Pringle for assistance in the preparation of the final version of the manuscript. Conflict of interest: No conflict of interest to declare.

This study was performed to investigate the role of dysglycemia on the genetic diversity of Mycobacterium tuberculosis (MTB) among pulmonary tuberculosis (TB) patients to build scientific evidence about the possible mechanisms of TB transmission. MTB isolates obtained of patients affected by pulmonary tuberculosis from health care facilities of North Lima—Peru, were analyzed using whole genome sequencing and 24-locus mycobacterial interspersed repetitive-unit -variable-number tandem repeats (MIRU-VNTR). Subsequently, clinical and epidemiological characteristics were associated with clustering, lineages and comorbid conditions. The analysis carried out 112 pulmonary TB patients from various health centers in North Lima, 17 (15%) had diabetes mellitus (DM) and 33 (29%) had prediabetes (PDM). Latin American-Mediterranean, Haarlem and Beijing were the most frequent MTB lineages found in th...