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artículo
Publicado 2018
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DNA damage inducible transcript 4 (DDIT4) gene is expressed under stress situations turning off the metabolic activity triggered by the mammalian target of rapamycin (mTOR). Several in vitro and in vivo works have demonstrated the ability of DDIT4 to generate resistance to cancer therapy. The link between the metabolism suppression and aggressiveness features of cancer cells remains poorly understood since anti-mTOR agents who are part of the repertoire of drugs used for systemic treatment of cancer achieving variable results. Interestingly, the high DDIT4 expression is associated with worse outcomes compared to tumors with low DDIT4 expression, seen in a wide variety of solid and hematological tumors, which suggests the driver role of this gene and provide the basis to target it as part of a new therapeutic strategy. In this review, we highlight our current knowledge about the biology o...
2
artículo
Publicado 2019
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A case of mandibular bone tumor, diagnosed as multicystic ameloblastoma, which was surgically managed, and is presented in the following article. This type of pathology is of odontogenic origin and in spite of being benign it has an aggressive behavior and usually requires a radical approach. After evaluating the case, the surgical removal of the tumor was chosen, which included wide mandibular bone recession with safety margins of 1cm followed by an immediate reconstruction with a fibula free flap. Surgical treatment was performed in the Dos de Mayo National Hospital’s, operating room, in charge of the Head and Neck and Maxillofacial Surgery Service, with a favorable evolution and without complications, waiting for oral rehabilitation
3
artículo
Publicado 2017
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DDIT4 gene encodes a protein whose main action is to inhibit mTOR under stress conditions whilst several in vitro studies indicate that its expression favors cancer progression. We have previously described that DDIT4 expression is an independent prognostic factor for tripe negative breast cancer resistant to neoadjuvant chemotherapy. We herein report that high DDIT4 expression is related to the outcome (recurrence-free survival, time to progression and overall survival) in several cancer types. We performed in silico analysis in online platforms, in pooled datasets from KM Plotter and meta-analysis of individual datasets from SurvExpress. High levels of DDIT4 were significantly associated with a worse prognosis in acute myeloid leukemia, breast cancer, glioblastoma multiforme, colon, skin and lung cancer. Conversely, a high DDIT4 expression was associated with an improved prognostic in ...
4
artículo
Publicado 2024
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Objective: To describe suicide mortality and its behavioral characteristics in Lima, Peru during the period 2017 - 2022. Methods: This was a descriptive observational study on suicide mortality and its behavioral characteristics found in Lima and its districts during the period 2017 - 2022. The sociodemographic characteristics and methods of suicide for the period 2017 - 2022 were described. Then, age-standardized mortality rates were estimated for Lima and its districts for each year and for the period 2017 - 2021. Results: There were 559 deaths by suicide during 2017 - 2022 in Lima with a ratio male/female of 2.6 and median age of 37. 68,78% were single, 44,54% had secondary education, 60,82% occurred at home with hanging being the main method of suicide with 70,98%. The overall suicide rate was 5,52 per 100 000 population for Lima during the period 2017 - 2021. Mortality increas...
5
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“Introduction: A high prevalence of advanced breast cancer (BC) is a common scenario in Latin America. In Peru, the frequency of BC at Stages III/IV is ≈50% despite implementation of a programme for breast cancer screening (BCS) along the country. We carried out a study to assess the feasibility and develop an instrument to evaluate the knowledge, barriers and perception about BCS in a nationwide pilot study in Peru among candidates for BCS. Methods: We conducted a systematic review of 2,558 reports indexed in PubMed, Scopus, Web of Science, Medline-Ovid and EMBASE, regarding to our study theme. In total, 111 were selected and a 51-items survey was developed (eight items about sociodemographic characteristics). Patients were recruited in public hospitals or private clinics, in rural and urban areas of nine departments of Peru. Results: We surveyed 488 women from: Lima (150), Cajamarc...
