El presente estudio realizado en zonas urbano marginales de la ciudad de Ayacucho tuvo como objetivo detectar prácticas inadecuadas de uso de medicamentos, corregirla mediante intervención educativa y determinar la eficacia de esta. La metodología utilizada fue la encuesta domiciliaria, para investigar las características de uso de medicamentos, en el tratamiento de las afecciones más comunes. El muestreo empleado fue aleatorio simple para escoger los domicilios a encuestar, que se dividieron en grupo intervenido y grupo control, donde los participantes fueron personas voluntarias. En una primera encuesta se encontró que las afecciones más frecuentes fueron el resfriado común y las enfermedades diarreicas agudas y que a menudo su manejo consistía en el uso inadecuado de medicamentos. Se llevaron a cabo intervenciones educativas de dos semanas por asentamiento humano, y posterior...

Se determinó la actividad antiinflamatoria y antioxidante del extracto hidroalcohólico de fruto de las variedades anaranjada, morada y blanca de Opuntia ficus-indica. Los métodos fueron: fenoles totales por Folin-Ciocalteu, flavonoides por cloruro de aluminio y la actividad antioxidante por DPPH, ABTS y FRAP; y la actividad antiinflamatoria in vitro por estabilización de membrana de glóbulos rojos. El contenido de fenoles totales fue 4,08, 3,87 y 3,69 mg EAG/g de extracto para las variedades anaranjada, blanca y morada, respectivamente (p>0,05); el de flavonoides fue mayor en la variedad anaranjada (2,36 mg EQ/g), seguida dela variedad morada (2,29 mg EQ/g) y blanca (2,0 mg EQ/g) (p<0,05), respectivamente. La capacidad secuestradora de radical libre DPPH de la variedad anaranjada presentó mayor actividad (6,20 μmol ET/g) (p<0,05), para ABTS la variedad morada presentó ma...

Objective: To evaluate the gastroprotective effect of mucilage extracted from Aloe vera (A. vera) leaves in albino rats. Materials and methods: The technique used was observation, and the method was based on inducing gastric ulcers with 96 % ethanol. The animals were divided into seven treatment groups: (I) control group, which received normal saline (4 mL/kg); (II)group administered 96 % ethanol (1 mL/animal); (III) group treated with ranitidine (100 mg/kg); (IV) group administered sucralfate (50 mg/kg); and (V–VII) groups treated with mucilage at doses of 25, 50, and 100 mg/kg, respectively. Results: The mean volumes of gastric content in animals treated with mucilage at doses of 50 and 100 mg/kg were statistically comparable to those in the ranitidine and sucralfate groups. The percentage efficiency in increasing gastric pH of the experimental animals was highest with ranitidine, fo...

Clinopodium bolivianum (Benth.) Kuntze, commonly known as muña, inca muña or koa, has traditionally been used for its medicinal properties in digestive disorders. Some studies have revealed its antioxidant potential and antibacterial activity. This study determined the volatile components, evaluated the antioxidant capacity of C. bolivianum essential oil and its incorporation into three hair cosmetic formulations: shampoo, combing cream, and capillary lotion. Gas Chromatography–Mass Spectrometry (GC–MS) confirmed pulegone as the main component, accounting for 66.85% of the essential oil. The antioxidant activity was assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays, with Trolox (6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) as a reference compound. The essential oil exhibited significant radi...

Schinus molle is a medicinal plant used as an anti-inflammatory and for rheumatic pain in the traditional medicine of Peru. On the other hand, Aedes aegypti is the main vector of several tropical diseases and the transmitter of yellow fever, chikungunya, malaria, dengue, and Zika virus. In this study, the aim was to investigate the antioxidant activity in vitro and the insecticidal activity in silico, in the presence of the mosquito juvenile hormone-binding protein (mJHBP) from Aedes aegypti, of the essential oil from S. molle leaves. The volatile phytochemicals were analyzed by gas chromatography-mass spectrometry (GC-MS), and the profile antioxidants were examined by DPPH, ABTS, and FRAP assays. The evaluation in silico was carried out on mJHBP (PDB: 5V13) with an insecticidal approach. The results revealed that EO presented as the main volatile components to alpha-phellandrene (32.68%...