Objetivo: Determinar la biodisponibilidad relativa de formulaciones orales de fenazopiridina en mujeres jóvenes. Metodología: Tipo de Investigación cuasi-experimental con un diseño cruzado entre los grupos de tratamiento. Se realizó en 12 mujeres sanas, entre 18 a 25 años de edad, seleccionadas · por un muestreo por conveniencia. Se constituyó dos grupos de seis mujeres cada uno, al primer grupo se administró 100 mg de fenazopiridina de IQfarma y al segundo grupo 100 mg de fenazopiridina de referencia (Pyridium ®) y a intervalos de 30 minutos se colectó la orina hasta las 6 horas, cuantificando el volumen correspondiente en cada recolección y el contenido de fenazopiridina por espectrofotometría a 390 nm. Con un intervalo de dos semanas entre ensayos, se·· invirtió la citada administración entre los grupos. En la determinación de la biodisponibilidad relativa de. la fen...

The anti-inflammatory and antioxidant activity of the hydroalcoholic extract of the fruit of the orange, purple and white varieties of Opuntia ficus-indica was determined. The methods were: total phenols by Folin-Ciocalteu, flavonoids by aluminum chloride and antioxidant activity by DPPH, ABTS and FRAP; the anti-inflammatory activity in vitro by the red blood cell membrane stabilization method. The total phenolic content for the orange, white and purple varieties were 4.08, 3.87 and 3.69 mg GAE/g (p> 0.05). The flavonoid content was higher in the orange variety with 2.36 mg QE/g, followed by the purple and white varietywith 2.29 and 2.0 mg QE/g (p <0.05). In the free radical scavenger for DPPH the orange variety presents a higher activity of 6.20 μmol TE/g (p <0.05), for ABTS the purple variety presents 25.35 μmol ET/g (p<0.05) and for the ferric reducing activity potential...

Schinus molle is a medicinal plant used as an anti-inflammatory and for rheumatic pain in the traditional medicine of Peru. On the other hand, Aedes aegypti is the main vector of several tropical diseases and the transmitter of yellow fever, chikungunya, malaria, dengue, and Zika virus. In this study, the aim was to investigate the antioxidant activity in vitro and the insecticidal activity in silico, in the presence of the mosquito juvenile hormone-binding protein (mJHBP) from Aedes aegypti, of the essential oil from S. molle leaves. The volatile phytochemicals were analyzed by gas chromatography-mass spectrometry (GC-MS), and the profile antioxidants were examined by DPPH, ABTS, and FRAP assays. The evaluation in silico was carried out on mJHBP (PDB: 5V13) with an insecticidal approach. The results revealed that EO presented as the main volatile components to alpha-phellandrene (32.68%...