El fucoidan de algas pardas es un polisacárido sulfatado con amplia variedad de actividades biológicas, entre ellas la modulación de la respuesta inmunitaria a través de la producción o inhibición de citoquinas, por lo cual, su uso en la terapia combinada con quimioterápicos convencionales contra distintos tipos de cáncer ha sido postulado en diversos estudios. El objetivo fue demostrar la inmunomodulación producida por el fucoidan VITALG® de L. trabeculata (FLt) sobre heteroesferoides sometidos a tratamiento combinado (doxorrubicina + fucoidan) y tratamiento simple (solo fucoidan), verificado mediante la producción de citoquinas. Ambos tratamientos fueron planteados en base a las IC50 de FLt y doxorrubicina (control positivo), los cuales se hallaron mediante el ensayo MTT, utilizando homoesferoides de células 4T1. Los heteroesferoides estuvieron compuestos de células 4T1 y ...

Acute stress is related to the energetic release of catecholamines, cytokines, and cortisol, which trigger pain perception. Chewing stimulates serotonergic neurons, these neurons modulate the neural pathways of pain; however, the relationship between these variables is still in the process of understanding. Objective. To determine the effect of acute stress and chewing stimulus on pain. Methods. an experiment that was developed in the Faculty of Medicine of the UNMSM. 40 eight-week-old male Balb/c mice were randomly assigned into 5 equal groups. A: week 1 without any stimulus and week 2 chewing stimulus + stress. B: week 1 without any stimulus and week 2 stress. C: week 1 stress and week 2 without any stimulus. D: week 1 masticatory stimulus + stress and week 2 without any stimulus. E: control, without any stimulus. Pain was assessed in the 5 groups at 7 and 14 days using the tail-withdr...

Introduction. Acute stress alters memory and spatial learning and the expression of interleukin 6, the chewing stimulus would prevent these effects. Objective. To determine the effect of chewing stimulation and acute stress on the expression of interleukin 6 and memory and spatial learning in mice. Methods. Experiment where 70 male albino mice of the Balb/c of age 2 month were randomly distributed into: Group A1: acute stress 1 hour; Group A2: acute stress 1 hour + chewing stimulus 1 hour; Group B1: acute stress 2 hours; Group B2: acute stress 2 hours + chewing stimulus 2 hours; Group C1: acute stress 3 hours; C2: acute stress 3 hours + chewing stimulus 3 hours; Group D: without intervention. For 3 days, spatial memory and learning were tested in the Morris water maze. Interleukin 6 (IL-6) was analyzed by ELISA test. Results. IL-6 was higher in the B2 group vs the other groups (p<0.00...