Introduction: Non-adherence to highly active antiretroviral treatment (HAART) is the principal reason of therapeutic failure. Objectives: To determine the prevalence and factors associated with non-adherence to HAART in HIV/AIDS patients. Design: Cross-sectional study. Setting: Infectious diseases service, Arzobispo Loayza National Hospital, a teaching hospital. Participants: HIV-infected patients on treatment with highly active antiretroviral treatment. Interventions: HIV-infected patients on treatment with highly active antiretroviral treatment were invited to complete a constructed questionnaire based on instruments evaluating adherence and associated factors. x2-test and Student’s t test were used to determine association; p-values below 0,05 were considered significant. Association magnitude was measured by OR and 95% confidence intervals. A multivariate logistic regression analys...