Objetivo: Determinar el nivel de conocimientos y prácticas sobre el manejo del traumatismo craneoencefálico (TEC) del médicos del servicio de emergencia del Hospital Carlos Monge Medrano, Juliaca, durante el periodo Enero Junio 2020. Materiales y métodos: Se desarrolló un estudio tipo descriptivo, observacional, transversal, prospectivo; realizado en médicos del servicio de emergencia del Hospital Carlos Monge Medrano, Juliaca utilizando un instrumento validado. Para determinar el nivel de conocimientos teóricos y prácticos sobre el manejo del traumatismo craneoencefálico. Se reportaron valores p menores de 0,05. Resultados: De un total de 40 participantes, se encontró que la derivación estándar (DE) fue de 2,86; el 55.% fue de sexo masculino, el 47.5% era médico especialista, el 60% egresó de una universidad nacional en el pregrado, el 40% laboraba en el servicio de emerge...

El objetivo de la presente investigación, fue determinar en qué medida los factores socioeconómicos influyen con las obligaciones tributarias en las MYPES delcentro comercial MEGACENCH, Lurigancho, 2021. El estudio se realizó a través de una metodología que considera un estudio de tipo aplicada, de alcance explicativa, de diseño no experimental y corte transversal, en donde la muestra estuvo constituida de 20 personas, a las que se les aplicó un cuestionario como instrumento de recolección de datos. Los resultados mostraron que, con un coeficiente de Chi cuadrado de 10,909 y con un p valor de 0.001, los factores socioeconómicos influyen significativamente en las obligaciones tributarias formales en las MYPES del centro comercial MEGACENCH,Lurigancho, 2021; también que, con un coeficiente de Chi cuadrado de 16,296 y con un p valor de 0.000, los factores socioeconómicos influye...

The immunomodulatory activity was studied in function of the production of γ−IFN induced by the methanolic extracts (ME) of the white, black, red and purple ecotypes of Lepidium peruvianum, Chacón (at present Lepidium meyenii Walp.) maca, on cultures of human T lymphocytes obtained of periferic blood. After cultivating the lymphocytes with the respective ME of maca during 14 hours, only the ME of the purple ecotype induced the significant production of IFN−γ by Elispot quantified. The methanolic extract of the purple ecotype of maca possesses important immunostimulatory properties triggering the activation of the human T lymphocytes.

The macrophages play an important role in the innate and adaptative response. Upon appropriate activation, macrophages released a variety of cytotoxic mediators like the Nitric Oxide (NO). The objective was to evaluate the production of NO for murine peritoneal macrophages cultivated with methanol extracts (ME) of different ecotypes of Lepidium peruvianum Chacón (at present Lepidium meyenii Walp.) red, black, purple and white. The ME was prepared using maca powdered macerated in methanol (1:2) during 10 days. Peritoneal macrophages were obtained of mice 3 days after having injected them 1 ml of thioglycolate broth; they were cultivated for triplicate during 18 hrs at 37 °C in RPMI 1640 medium supplemented with 10% fetal calf serum. The dose of ME was of 800 μg/ml for ecotype, were considered controls without ME. The production of NO was assayed by nitrite accumulation in the supernata...

The immunomodulatory activity was studied in function of the production of γ−IFN induced by the methanolic extracts (ME) of the white, black, red and purple ecotypes of Lepidium peruvianum, Chacón (at present Lepidium meyenii Walp.) maca, on cultures of human T lymphocytes obtained of periferic blood. After cultivating the lymphocytes with the respective ME of maca during 14 hours, only the ME of the purple ecotype induced the significant production of IFN−γ by Elispot quantified. The methanolic extract of the purple ecotype of maca possesses important immunostimulatory properties triggering the activation of the human T lymphocytes.

The macrophages play an important role in the innate and adaptative response. Upon appropriate activation, macrophages released a variety of cytotoxic mediators like the Nitric Oxide (NO). The objective was to evaluate the production of NO for murine peritoneal macrophages cultivated with methanol extracts (ME) of different ecotypes of Lepidium peruvianum Chacón (at present Lepidium meyenii Walp.) red, black, purple and white. The ME was prepared using maca powdered macerated in methanol (1:2) during 10 days. Peritoneal macrophages were obtained of mice 3 days after having injected them 1 ml of thioglycolate broth; they were cultivated for triplicate during 18 hrs at 37 °C in RPMI 1640 medium supplemented with 10% fetal calf serum. The dose of ME was of 800 μg/ml for ecotype, were considered controls without ME. The production of NO was assayed by nitrite accumulation in the supernata...

The classic treatment of the cutaneous leishmaniosis consists on the injection of 15-20 ampoule of Glucantine what causes serious secondary effects. This fact justifies the search of new medications what motivated the present investigation. The objective was to evaluate the leishmanicidal activity of the methanolic extracts (ME) of the white, red, purple and black ecotypes of Lepidium peruvianum Chacón (at present Lepidium meyenii Walp.) about the growth of Leishmania braziliensis peruviana in vitro. The promastigotes reached the logarithmic phase to the fifth day of cultivation at 27 ºC in the two-phase Columbia medium with 15% of defibrinated sheep blood and they faced, for separate, with the ME to concentrations of 50, 100, 200 and 400 μg/ml. The recounts were made daily with camera Neubauer. The maximum decrease of promastigotes (17.41% of viability) took place to the second day f...

The classic treatment of the cutaneous leishmaniosis consists on the injection of 15-20 ampoule of Glucantine what causes serious secondary effects. This fact justifies the search of new medications what motivated the present investigation. The objective was to evaluate the leishmanicidal activity of the methanolic extracts (ME) of the white, red, purple and black ecotypes of Lepidium peruvianum Chacón (at present Lepidium meyenii Walp.) about the growth of Leishmania braziliensis peruviana in vitro. The promastigotes reached the logarithmic phase to the fifth day of cultivation at 27 ºC in the two-phase Columbia medium with 15% of defibrinated sheep blood and they faced, for separate, with the ME to concentrations of 50, 100, 200 and 400 μg/ml. The recounts were made daily with camera Neubauer. The maximum decrease of promastigotes (17.41% of viability) took place to the second day f...

The search of natural compound with cytotoxic and antitumoural activities is one of the current priorities of the fight against the cancer; being necessary to analyze new extracts of plants. The objective in this paper was to evaluate the cytotoxic activity of the methanolic extract (ME) of the black, purple and yellow ecotypes of Lepidium peruvianum, Chacón (at present Lepidium meyenii Walp.), Maca, on the cellular lines HeLa (Human Epithelial Carcinoma) and HT-29 (Human Colon Adenocarcinoma). For the cellular line HT-29, the inhibitory concentration of 50% of the cellular growth (IC50) with the black, purple and yellow ecotypes was of 8,32 mg/ml, 9,28 mg/ml and 0,487 mg/ml, respectively; while for the cellular line HeLa was of 2,4 mg/ml, 1,93 mg/ml and 0,66 mg/ml respectively. Additionally, ME of the yellow ecotype was evaluated with two years of storage (10ºC) determining an IC50 4,...

The search of natural compound with cytotoxic and antitumoural activities is one of the current priorities of the fight against the cancer; being necessary to analyze new extracts of plants. The objective in this paper was to evaluate the cytotoxic activity of the methanolic extract (ME) of the black, purple and yellow ecotypes of Lepidium peruvianum, Chacón (at present Lepidium meyenii Walp.), Maca, on the cellular lines HeLa (Human Epithelial Carcinoma) and HT-29 (Human Colon Adenocarcinoma). For the cellular line HT-29, the inhibitory concentration of 50% of the cellular growth (IC50) with the black, purple and yellow ecotypes was of 8,32 mg/ml, 9,28 mg/ml and 0,487 mg/ml, respectively; while for the cellular line HeLa was of 2,4 mg/ml, 1,93 mg/ml and 0,66 mg/ml respectively. Additionally, ME of the yellow ecotype was evaluated with two years of storage (10ºC) determining an IC50 4,...