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artículo

Diagnostic performance of three non-invasive fibrosis scores (Hepamet, FIB-4, NAFLD fibrosis score) in NAFLD patients from a mixed Latin American population

Publicado por
Zambrano-Huailla, Rommel, Guedes, Laura, Stefano, Jose Tadeu, de Souza, Arthur A. Arrais, Marciano, Sebastián, Yvamoto, Erika, Michalczuk, Matheus Truccolo, Vanni, Denise Siqueira, Rodriguez, Hernan, Carrilho, Flair Jose, Alvares-da-Silva, Mario Reis, Gadano, Adrian, Arrese, Marco, Miranda, Adelina Lozano, Oliveira, Claudia P.

Publicado 2020

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Introduction and aims Several non-invasive scoring systems have been developed and validated worldwide to predict the risk of liver fibrosis in nonalcoholic fatty liver disease (NAFLD). However, information about the performance of these systems in Latin American populations is scarce. Our aim was to evaluate the performance of the Hepamet Fibrosis Score, Fibrosis-4 (FIB-4) and the NAFLD Fibrosis Score (NFS) in a mixed Latin American group of NAFLD patients. Methods Clinical, laboratory and liver biopsy data collected from 379 biopsy-proven NAFLD patients from Latin American tertiary health centers were reviewed. Histological fibrosis stages were classified using the Kleiner score. Accuracy was determined, and new fibrosis score thresholds were calculated to better compare the performances of non-invasive tests and to explore their usefulness in excluding fibrosis. Results The distributi...

artículo

Latin American Association for the study of the liver (ALEH) practice guidance for the diagnosis and treatment of non-alcoholic fatty liver disease

Publicado por
Arab, Juan Pablo, Dirchwolf, Melisa, Álvares-da-Silva, Mário Reis, Barrera, Francisco, Benítez, Carlos, Castellanos-Fernandez, Marlene, Castro-Narro, Graciela, Chavez-Tapia, Norberto, Chiodi, Daniela, Cotrim, Helma, Cusi, Kenneth, de Oliveira, Claudia Pinto Marques Souza, Díaz, Javier, Fassio, Eduardo, Gerona, Solange, Girala, Marco, Hernandez, Nelia, Marciano, Sebastián, Masson, Walter, Méndez-Sánchez, Nahum, Leite, Nathalie, Lozano, Adelina, Padilla, Martín, Panduro, Arturo, Paraná, Raymundo, Parise, Edison, Perez, Marlene, Poniachik, Jaime, Restrepo, Juan Carlos, Ruf, Andrés, Silva, Marcelo, Tagle, Martín, Tapias, Monica, Torres, Kenia, Vilar-Gomez, Eduardo, Costa Gil, José Eduardo, Gadano, Adrian, Arrese, Marco

Publicado 2020

Enlace

Non-alcoholic fatty liver disease (NAFLD) currently represents an epidemic worldwide. NAFLD is the most frequently diagnosed chronic liver disease, affecting 20–30% of the general population. Furthermore, its prevalence is predicted to increase exponentially in the next decades, concomitantly with the global epidemic of obesity, type 2 diabetes mellitus (T2DM), and sedentary lifestyle. NAFLD is a clinical syndrome that encompasses a wide spectrum of associated diseases and hepatic complications such as hepatocellular carcinoma (HCC). Moreover, this disease is believed to become the main indication for liver transplantation in the near future. Since NAFLD management represents a growing challenge for primary care physicians, the Asociación Latinoamericana para el Estudio del Hígado (ALEH) has decided to organize this Practice Guidance for the Diagnosis and Treatment of Non-Alcoholic F...