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El cáncer de mama es una de las primeras causas de mortalidad a nivel mundial, la detección temprana esta en relación directa con la disminución de la morbimortalidad, por ello se pone en disyuntiva si se debe realizar el Screening a la población en general o realizar la valoración individual del riesgo. Es importante hacerse una mamografía anual a partir de los 40 años.
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tesis de maestría
Objetivo General: Evaluar la escala de riesgo FINDRISK como método de screening para insulinoresistencia, prediabetes y diabetes en la en consulta externa en HNAL durante el 2018 Método: Estudio es de tipo descriptivo observacional de corte transversal y prospectivo con muestreo No aleatorizado – Por Conveniencia. Criterios de Inclusión: Paciente de consulta externa del Hospital Nacional Arzobispo Loayza y Paciente mayor de 18 años. Criterios de Exclusión: Mujeres embarazadas, Paciente menor de 18 años. Diagnóstico previo de DM 2, No acepten entrar al estudio (no firma de consentimiento informado) La Población será la atendida en Consulta externa en un año: (411,800 en promedio) La muestra se hallará con un Nivel de confianza= 95% y Margen de error= 5%. Los resultados del test y del laboratorio se reunirán en una base de datos, en el programa Microsoft Excel. Luego se proce...
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artículo
Since plants may contain hundreds or even thousands metabolites, the vegetable kingdom can be a posible source of new compounds for introduction into therapeutical screenning programmes. A realistic approach to this fascinating challenge is the development of the ethnopharmacology. In contrast to medicinal chemistry, ethnopharmacology can start from an observed activity of a drug used in man or animals. Subsequent bioassay-direct fractionation can lead to the discovery of previosly unknown chemical structures for further structure-activity studies. With automated sample injection and fraction collection, HPLC systems can readily and rapidly be used to isolale tens of milligrams of pure compound, whose structure is usually resolved by use of NMR spectroscopy. Finally, we have two strong recommendations to phytochemists entering this field: (i) Never launch a major project unless a suffici...
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artículo
Since plants may contain hundreds or even thousands metabolites, the vegetable kingdom can be a posible source of new compounds for introduction into therapeutical screenning programmes. A realistic approach to this fascinating challenge is the development of the ethnopharmacology. In contrast to medicinal chemistry, ethnopharmacology can start from an observed activity of a drug used in man or animals. Subsequent bioassay-direct fractionation can lead to the discovery of previosly unknown chemical structures for further structure-activity studies. With automated sample injection and fraction collection, HPLC systems can readily and rapidly be used to isolale tens of milligrams of pure compound, whose structure is usually resolved by use of NMR spectroscopy. Finally, we have two strong recommendations to phytochemists entering this field: (i) Never launch a major project unless a suffici...
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artículo
Introduction. The combined first-trimester screening test is the international recommendation for prenatal screening of trisomy 21. The combined plus screening test adds one or more ultrasound markers (ductus venosus, tricuspid flow, nasal bone). The contingent test is a two-step protocol of risk assessment that considers all markers only as a contingency in the group with an inconclusive result. Objective: Assessment of the performance of the Kagan biochemical contingent protocol in our population. Methods. All pregnant women between 11 and 13 weeks attended in our unit were assessed with the first-trimester combined plus screening test. We followed the Fetal Medicine Foundation published quality criteria and the International Society of Ultrasound in Obstetrics and Gynaecology guidelines. Results 2 578 single pregnancies were assessed; the foetuses were classified by an initial ultraso...
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tesis doctoral
El presente trabajo da a conocer los resultados de Validez y Confiabilidad del Cuestionario Salamanca para el Screening de trastornos de Personalidad, aplicados a la población universitaria peruana del contexto local con edades comprendidas entre 16 a 40 años, dando por resultado que el Alfa de Cronbach es 0.841 considerada como alta. Así mismo es significativo e importante el instrumento, ya que se logró adaptarlo a nuestro medio local. Es importante precisar que, en nuestra sociedad peruana, los test de evaluación con enfoque clínico son de larga duración solo para medir personalidad, las bondades de este instrumento es que cuenta con 22 ítems normalizados, apropiados a nuestra terminología y que mide los cuadros clínicos basándose en los enfoques teóricos del DSM-IV y DSM-5 (Manuel estadístico de trastornos mentales) y CIE-11 (International Classification of Diseases) res...
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tesis de grado
El presente proyecto tiene como fin determinar el riesgo de desnutrición presente en la mayoría de los pacientes pediátricos hospitalizados, ya que dicho riesgo puede agravar la morbilidad y en algunas situaciones comprometer la vida del paciente. En su mayoría, los pacientes pediátricos hospitalizados solo reciben cuidados por la patología por la cual fueron ingresaron, olvidando que el niño es un ser en desarrollo, y que valorar su crecimiento es de interés. Por ello, la importancia de la implementación de un tamizaje para prevenir dichos riesgos y tomar las precauciones necesarias, así como, mejorar la calidad de atención de los pacientes en las múltiples esferas de atención. El uso del tamizaje STRONGkids es práctico y sencillo, no siendo necesario antropometría previa y analítica laboratorial, pudiendo incluso aplicarse de forma virtual, lo que simplifica su utilidad...
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artículo
Breast cancer is the second most frequent malignant neoplasm in the world and the fifth cause of death from cancer in women. In Peru, breast cancer is second in incidence and the third cause of death from cancer in women. Mammography screening began in 1960 with the goal of detecting cancer at its smallest size before clinically evident in order to have better prognosis and survival. Several trials have been done since to determine mammography importance as a screening method and to establish age to begin, frequency and when to stop screening. In this article the role of mammography as screening tool is reviewed, as well as controversies on use, side effects, and recommendations on its use in Peru.
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artículo
Congenital sensorineural hearing loss is one of the most frequent pathologies of the newborn. To carry out the diagnosis and early detection of this pathology in the pediatric population, specialized audiological tests are required, such as otoacoustic emissions and auditory evoked potentials. Therefore, it is important to have a guide to identify and detect those patients with suspected congenital sensorineural hearing loss.
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artículo
Congenital sensorineural hearing loss is one of the most frequent pathologies of the newborn. To carry out the diagnosis and early detection of this pathology in the pediatric population, specialized audiological tests are required, such as otoacoustic emissions and auditory evoked potentials. Therefore, it is important to have a guide to identify and detect those patients with suspected congenital sensorineural hearing loss.
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artículo
OBJETIVE: To determine the value of the clock drawing test as a assessment tool for Alzheimer’s disease in elderly patients. MATERIAL AND METHODS: The clock drawing test was applied to patients with and without Alzheimer’s disease attended at the Almenara Hospital Geriatrics Department, Lima Perú. The sample consisted in 31 outpatients (10 males, 21 women) with Alzheimer’s disease and 31 outpatients without this disease (21 males, 10 women). They were requested to draw a clock, using standardized instructions (tenpoint clock drawing test ). Patient with Alzheimer’s disease were graded according to the Hughes’ Clinical Dementia Rating (mild in 10, moderate in 12 and severe in 9). RESULTS: Using a 6-point score as cut off the ten-point clock drawing test had a sensitivity of 83,9%, specificity of 93,5, positive predictive value of 92,9% and negative predictive value 83,5%. CONCL...
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artículo
Objectives. The study aims to implement a test for the detection ande treatment of chlamydia during antenatal care, determining the acceptability and feasibility of universal screening and to measure adherence of the patient and her family and also to estimate the prevalence of chlamydia in pregnant women. Material and methods. A prospective study was conducted in pregnant women > 16 years, in 2 large hospitals in Lima (Instituto Nacional Materno Perinatal y Hospital Arzobispo Loayza) during 2013. Chlamydia screening is offered to pregnant women during their first prenatal care using self-administered vaginal swabs (Aptima Combo 2 assay®, Hologic Gen-Probe). We contacted patients positive for Chlamydia within 14 days, they were given free counseling and directly observed treatment with azithrommycin 1 gram oral route to her and her partner. The pregnant women attending alone, we...
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artículo
Objectives. The study aims to implement a test for the detection ande treatment of chlamydia during antenatal care, determining the acceptability and feasibility of universal screening and to measure adherence of the patient and her family and also to estimate the prevalence of chlamydia in pregnant women. Material and methods. A prospective study was conducted in pregnant women > 16 years, in 2 large hospitals in Lima (Instituto Nacional Materno Perinatal y Hospital Arzobispo Loayza) during 2013. Chlamydia screening is offered to pregnant women during their first prenatal care using self-administered vaginal swabs (Aptima Combo 2 assay®, Hologic Gen-Probe). We contacted patients positive for Chlamydia within 14 days, they were given free counseling and directly observed treatment with azithrommycin 1 gram oral route to her and her partner. The pregnant women attending alone, we...
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artículo
The silk screen printing used by the micro and small businesses (MYPE for its acronym in Spanish) of Peru, is characterized for being artisanal, which means that they use clean technologies, however, they don’t use ecological inputs. Peru is a rich country in the tradition of use of natural inks from the time of inca and preinca’s cultures. At present mentioned tradition is limited to clothes elaborated for foreign tourists and in far places of difficult access. In the essays made to obtain a natural ink for the printing process, tests have been made with eucalyptus (Eucalyptus), getting good results with the system consisting of the extract of eucalyptus leaves and starch as vehicle.
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artículo
The silk screen printing used by the micro and small businesses (MYPE for its acronym in Spanish) of Peru, is characterized for being artisanal, which means that they use clean technologies, however, they don’t use ecological inputs. Peru is a rich country in the tradition of use of natural inks from the time of inca and preinca’s cultures. At present mentioned tradition is limited to clothes elaborated for foreign tourists and in far places of difficult access. In the essays made to obtain a natural ink for the printing process, tests have been made with eucalyptus (Eucalyptus), getting good results with the system consisting of the extract of eucalyptus leaves and starch as vehicle.
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artículo
Introduction: Cervical cancer is one of the neoplasms with the highest incidence in Peru. The great gap in access to primary care reflects the need for effective diagnostic tests. Objetives:  To evaluate the diagnostic capacity between colposcopic and cytological tests in the detection of cervix lesion in patients treated at the Alberto Leopoldo Barton Thompson Hospital Complex.  Objetives:  To evaluate the diagnostic capacity between colposcopic and cytological tests in the detection of cervix lesion in patients treated at the Alberto Leopoldo Barton Thompson Hospital Complex. Material and methods:  Study of diagnostic tests  that investigated patients who attended the cervical screening clinic of the Alberto Leopoldo Barton Thompson Hospital Complex. Sensitivity (S), specificity (E), predictive values, percentage of agreement and diagnostic odd ratio (ORD) were calculated. Results...
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artículo
Objective: To report the results of pulse oximetry screening for congenital heart diseases in healthy newborns during the transitional period between birth and discharge. Those with positive screening results were referred for echocardiographic evaluation aimed at a specific diagnosis. Materials and methods: A retrospective, descriptive, observational and cross-sectional study. Data were obtained from screening 4,897 newborns who were admitted to the nursery of the Obstetrics and Gynecology Unit at Hospital Universitario de Guayaquil, within the first 24 hours of birth, all diagnosed as healthy newborns. As part of the protocol, cardiac screening was performed on all newborns at admission and discharge. Newborns with saturation levels below 95 % on pulse oximetry underwent consecutive measurements at one-hour intervals, with a total of three readings. Additionally, those with more than a...
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artículo
In a probabilistic and representative sample from Santiago, Chile, this research aims to validate the Spanish-language National Opinion Research Center DSM-IV Screen for Gambling Problems (NODS) and its abbreviated form for the Chilean context. 1032 individuals were surveyed at home using a standardized questionnaire. Results show high reliability for both lifetime and past-year versions of the screening, with structural validity supported by factor analyses. The study found 2.4% of the sample classified as lifetime pathological gamblers and 0.8% for the past year, consistent with higher ranges of international studies. Severe gambling disorder rates are higher in Chile compared to Spain. Concurrent validity suggests that the lengthy Chilean adaptation of NODS is reliable for assessing gambling problems.Keywords: gambling; gambling problems; validation.
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tesis de maestría
Menciona que la enfermedad de Chagas, causada por el parásito Trypanosoma cruzi, es endémica de Latinoamérica y afecta entre 16 y 18 millones de personas. Su tratamiento requiere de drogas más efectivas y menos tóxicas. Con el propósito de contar con un método de screening de drogas más sensible y rápido que facilite la selección de compuestos tripanosomicidas candidatos, se planteó como objetivo desarrollar parásitos de T. cruzi que expresen el gen reportero de la luciferasa (luc) de la luciérnaga Photinus pyralis en forma estable. Para la obtención de parásitos luc- transfectantes se construyeron dos plásmidos conteniendo el ORF de luc: el pBS-Neo-Luc y el pR-Luc-Neo. Epimastigotes de la cepa boliviana DH29 fueron electroporados con el DNA circular de estos plásmidos. Los clones fueron obtenidos por diluciones limitantes de los parásitos transfectantes resistentes al ...