Basado en el efecto clínico diferencial de la acción de un nuevo radiosensibilizador de células hipóxicas, el AK-2123 (3-Nitro-1, 2, 4 - triazole), en el cáncer de cuello uterino localmente avanzado (estadíos II-B y III-B), se ha llevado a cabo un protocolo clínico fase I/II en 80 pacientes consecutivos a quienes se les inyectó intratumoralmente soluciones al 1 por ciento y 2 por ciento de AK-2123; 30 minutos antes de la administración de radioterapia externa. Los resultados preliminares muestran que las lesiones exofíticas responden mucho mejor que las endofíticas y el AK-2123 podría reemplazar al radium intracavitario para la variedad exofítica del estadío II-B del cáncer de cuello uterino, siendo la terapia estándard para esta neoplasia en nuestros pacientes. El tratamiento es bien tolerado y no desarrolla toxicidad neurológica.

Of the 17.326 patients with cervical cancer registered in the INEN between 1952 and 1979, 403 were 76 years or older at diagnosis (2.3%). The average age in this group was 80.6 years and older was 99 years. The first sex was at 19 and the average latency period 61 years, in contrast to 16 and seven years for the group of 123 patients under 25 years. The distribution showed predominance of clinical stay in the añosas advanced disease, although the parametrial involvement (comparison between stays A and B) was significantly lower (p <0.001) than in young, possibly due to anatomical changes involution. Squamous cell carcinoma was the predominant type and significantly more frequent (98%) in those over 76, with lower incidence of adenocarcinoma and mucoepidermoid carcinoma. The linioplasmocitario cervical stromal infiltrate was more frequent in younger patients, in which an inverse relation...

Of the 17.326 patients with cervical cancer registered in the INEN between 1952 and 1979, 403 were 76 years or older at diagnosis (2.3%). The average age in this group was 80.6 years and older was 99 years. The first sex was at 19 and the average latency period 61 years, in contrast to 16 and seven years for the group of 123 patients under 25 years. The distribution showed predominance of clinical stay in the añosas advanced disease, although the parametrial involvement (comparison between stays A and B) was significantly lower (p <0.001) than in young, possibly due to anatomical changes involution. Squamous cell carcinoma was the predominant type and significantly more frequent (98%) in those over 76, with lower incidence of adenocarcinoma and mucoepidermoid carcinoma. The linioplasmocitario cervical stromal infiltrate was more frequent in younger patients, in which an inverse relat...

The literature is reviewed admitting the characteristics of this tumor as primitive mesonephric duct, but its proximity to the ovary will be included in this organ. Histogenetic is analyzed and representative cases of the literature is concerned. We report a single case registered in the No. 2 Central Hospital of the Social Security of Peru in 15 years of existence. Its location was in right ovary with right parametrial invasion and omentum. A month after his speech there recurrent disease with pulmonary metastases and vaginal vault that do not yield to cobalt treatment, chemotherapy or endocrine therapy. Died 5 months after surgery.

The literature is reviewed admitting the characteristics of this tumor as primitive mesonephric duct, but its proximity to the ovary will be included in this organ. Histogenetic is analyzed and representative cases of the literature is concerned. We report a single case registered in the No. 2 Central Hospital of the Social Security of Peru in 15 years of existence. Its location was in right ovary with right parametrial invasion and omentum. A month after his speech there recurrent disease with pulmonary metastases and vaginal vault that do not yield to cobalt treatment, chemotherapy or endocrine therapy. Died 5 months after surgery.

Background: There are limited data from retrospective studies regarding whether survival outcomes after laparoscopic or robot-assisted radical hysterectomy (minimally invasive surgery) are equivalent to those after open abdominal radical hysterectomy (open surgery) among women with early-stage cervical cancer. Methods: In this trial involving patients with stage IA1 (lymphovascular invasion), IA2, or IB1 cervical cancer and a histologic subtype of squamous-cell carcinoma, adenocarcinoma, or adenosquamous carcinoma, we randomly assigned patients to undergo minimally invasive surgery or open surgery. The primary outcome was the rate of disease-free survival at 4.5 years, with noninferiority claimed if the lower boundary of the two-sided 95% confidence interval of the between-group difference (minimally invasive surgery minus open surgery) was greater than -7.2 percentage points (i.e., clos...

Identificar los factores de riesgo de morbilidad postoperatoria en histerectomía radical por cáncer de cuello uterino en etapa temprana en pacientes mujeres del IREN durante el periodo 2009 – 2019. Materiales y Métodos: Se basa en un estudio transversal analítico en donde se incluirán a mujeres asistidas en el Servicio de Ginecología Oncológica de dicho establecimiento durante el periodo 2009 – 2019. Se obtuvieron los datos mediante tablas de doble entrada, empleando el programa SPSS versión 25.0. y haciendo uso de una prueba de chi cuadrado. Resultados: En el estudio de 169 pacientes mujeres que presentaron cáncer de cuello uterino en etapa temprana con factores de riesgo de morbilidad postoperatoria de histerectomía radical del IREN durante el periodo 2009 – 2019, se encontró que los estadios FIGO IA, IB, IIA desarrollaron morbilidad de 9 (5,3%), 77 (45,6%) y 5 (3,0%) ...

La presente investigación tuvo por objetivo general: “Determinar la manera de aplicación de los criterios legales de determinación del monto de la pensión de alimentos en los Juzgados de Paz Letrados de la provincia de La Convención, Cusco 2019”, los objetivos específicos están referidos a, cconocer los criterios legales aplicados para la determinación del monto de la pensión de alimentos por los Juzgados de Paz Letrado de La Convención, Cusco, 2019, evaluar la uniformidad de criterios para fijar la pensión de alimentos en los Juzgados de Paz Letrado de La Convención, Cusco 2019, fundamentar las consideraciones jurídicas para la propuesta de una reforma legislativa que establezca parámetros más adecuados en la determinación de la pensión de alimentos. Se postuló como hipótesis general que: “Teniendo en cuenta, la falta de una adecuada delimitación del artículo ...