Collision tumour of large-cell neuroendocrine carcinoma and adenocarcinoma in the stomach: A case report.

• Autores: Payet, Eduardo, Pilco, Pau I, Montes, Jaime, Cordero Morales, Alejandra, Savitzky, Maria Jose, Stenning Persivale, Karoline Andrea
• Formato: artículo
• Fecha de Publicación: 2016
• Institución: Universidad Peruana de Ciencias Aplicadas
• Repositorio: UPC-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorioacademico.upc.edu.pe:10757/604496
• Enlace del recurso: http://hdl.handle.net/10757/604496
• Nivel de acceso: acceso abierto
• Materia: Adenocarcinoma; Carcinoma; Collision tumour; Neuroendocrine

Concurrence of adenocarcinoma and large-cell neuroendocrine carcinoma of the stomach is a rare condition. Here, we report a case of gastric collision tumour with large-cell neuroendocrine carcinoma and adenocarcinoma. A 71-year-old Peruvian man presented with nausea, epigastric pain, and weight loss for seven months. An Endoscopic evaluation revealed a huge ulcerative and infiltrative mass in the upper and middle third of the stomach. The patient underwent a D2 total gastrectomy. Microscopically, two separated and attached ulcerative lesions were recognised. The proximal to the cardial lesion showed neuroendocrine morphology and immunoreactivity for synaptophysin, and the other a moderated tubular adenocarcinoma Borrmann type III. Both lesions invaded serosa and lymph nodes metastases were found in 17 of 41 lymph nodes retrieved (one lymph node with neuroendocrine metastatic deposits).