Age-related susceptibility to infection with diarrheagenic Escherichia coli among infants from Periurban areas in Lima, Peru

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Theresa.J.Ochoa@uth.tmc.edu
Detalles Bibliográficos
Autores: Ochoa, Theresa J., Ecker, Lucie, Barletta, Francesca, Mispireta, Mónica L., Gil, Ana I., Contreras, Carmen, Molina, Margarita, Amemiya, Isabel, Verastegui, Hector, Hall, Eric R., Cleary, Thomas G., Lanata, Claudio F.
Formato: artículo
Fecha de Publicación:2015
Institución:Universidad Peruana de Ciencias Aplicadas
Repositorio:UPC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorioacademico.upc.edu.pe:10757/556074
Enlace del recurso:http://hdl.handle.net/10757/556074
Nivel de acceso:acceso abierto
Materia:Diarrheagenic E. coli
Age-related susceptibility
Diarrhea
Infants
Peru
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dc.title.es_PE.fl_str_mv Age-related susceptibility to infection with diarrheagenic Escherichia coli among infants from Periurban areas in Lima, Peru
title Age-related susceptibility to infection with diarrheagenic Escherichia coli among infants from Periurban areas in Lima, Peru
spellingShingle Age-related susceptibility to infection with diarrheagenic Escherichia coli among infants from Periurban areas in Lima, Peru
Ochoa, Theresa J.
Diarrheagenic E. coli
Age-related susceptibility
Diarrhea
Infants
Peru
title_short Age-related susceptibility to infection with diarrheagenic Escherichia coli among infants from Periurban areas in Lima, Peru
title_full Age-related susceptibility to infection with diarrheagenic Escherichia coli among infants from Periurban areas in Lima, Peru
title_fullStr Age-related susceptibility to infection with diarrheagenic Escherichia coli among infants from Periurban areas in Lima, Peru
title_full_unstemmed Age-related susceptibility to infection with diarrheagenic Escherichia coli among infants from Periurban areas in Lima, Peru
title_sort Age-related susceptibility to infection with diarrheagenic Escherichia coli among infants from Periurban areas in Lima, Peru
author Ochoa, Theresa J.
author_facet Ochoa, Theresa J.
Ecker, Lucie
Barletta, Francesca
Mispireta, Mónica L.
Gil, Ana I.
Contreras, Carmen
Molina, Margarita
Amemiya, Isabel
Verastegui, Hector
Hall, Eric R.
Cleary, Thomas G.
Lanata, Claudio F.
author_role author
author2 Ecker, Lucie
Barletta, Francesca
Mispireta, Mónica L.
Gil, Ana I.
Contreras, Carmen
Molina, Margarita
Amemiya, Isabel
Verastegui, Hector
Hall, Eric R.
Cleary, Thomas G.
Lanata, Claudio F.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ochoa, Theresa J.
Ecker, Lucie
Barletta, Francesca
Mispireta, Mónica L.
Gil, Ana I.
Contreras, Carmen
Molina, Margarita
Amemiya, Isabel
Verastegui, Hector
Hall, Eric R.
Cleary, Thomas G.
Lanata, Claudio F.
dc.subject.es_PE.fl_str_mv Diarrheagenic E. coli
Age-related susceptibility
Diarrhea
Infants
Peru
topic Diarrheagenic E. coli
Age-related susceptibility
Diarrhea
Infants
Peru
description Theresa.J.Ochoa@uth.tmc.edu
publishDate 2015
dc.date.accessioned.es_PE.fl_str_mv 2015-05-30T17:22:20Z
dc.date.available.es_PE.fl_str_mv 2015-05-30T17:22:20Z
dc.date.issued.fl_str_mv 2015-05-30
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dc.identifier.issn.es_PE.fl_str_mv 1058-4838
dc.identifier.pmid.es_PE.fl_str_mv 19857163
dc.identifier.doi.es_PE.fl_str_mv 10.1086/648069.
dc.identifier.uri.es_PE.fl_str_mv http://hdl.handle.net/10757/556074
dc.identifier.eissn.es_PE.fl_str_mv 1537-6591
dc.identifier.journal.es_PE.fl_str_mv Clinical Infectious Diseases (Clin Infect Dis)
dc.identifier.pmcid.es_PE.fl_str_mv PMC2779581
identifier_str_mv 1058-4838
19857163
10.1086/648069.
1537-6591
Clinical Infectious Diseases (Clin Infect Dis)
PMC2779581
url http://hdl.handle.net/10757/556074
dc.language.iso.es_PE.fl_str_mv eng
language eng
dc.relation.url.es_PE.fl_str_mv http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779581/
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eu_rights_str_mv openAccess
dc.format.es_PE.fl_str_mv application/pdf
dc.publisher.es_PE.fl_str_mv Oxford University Press
dc.source.es_PE.fl_str_mv Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Académico - UPC
dc.source.none.fl_str_mv reponame:UPC-Institucional
instname:Universidad Peruana de Ciencias Aplicadas
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instname_str Universidad Peruana de Ciencias Aplicadas
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spelling Ochoa, Theresa J.Ecker, LucieBarletta, FrancescaMispireta, Mónica L.Gil, Ana I.Contreras, CarmenMolina, MargaritaAmemiya, IsabelVerastegui, HectorHall, Eric R.Cleary, Thomas G.Lanata, Claudio F.2015-05-30T17:22:20Z2015-05-30T17:22:20Z2015-05-301058-48381985716310.1086/648069.http://hdl.handle.net/10757/5560741537-6591Clinical Infectious Diseases (Clin Infect Dis)PMC2779581Theresa.J.Ochoa@uth.tmc.eduArticleBACKGROUND: Diarrheagenic Escherichia coli strains are being recognized as important pediatric enteropathogens worldwide. However, it is unclear whether there are differences in age-related susceptibility to specific strains, especially among infants. METHODS: We conducted a passive surveillance cohort study of diarrhea that involved 1034 children aged 2-12 months in Lima, Peru. Control stool samples were collected from randomly selected children without diarrhea. All samples were analyzed for common enteric pathogens and for diarrheagenic E. coli with use of multiplex real-time polymerase chain reaction. RESULTS: The most frequently isolated pathogens in 1065 diarrheal episodes were diarrheagenic E. coli strains (31%), including enteroaggregative (15.1%) and enteropathogenic E. coli (7.6%). Diarrheagenic E. coli, Campylobacter species, and rotavirus were more frequently isolated from infants aged >or=6 months. Among older infants, diffusely adherent E. coli and enterotoxigenic E. coli were more frequently isolated from diarrheal samples than from control samples (P <.05). Children aged >or=6 months who were infected with enterotoxigenic E. coli had a 4.56-fold increased risk of diarrhea (95% confidence interval, 1.20-17.28), compared with younger children. Persistent diarrhea was more common in infants aged <6 months (13.5% vs 3.6%; P <.001). Among children with diarrheagenic E. coli-positive samples, coinfections with other pathogens were more common in children with diarrhea than in control children (40.1% vs 15.6%; P <.001). CONCLUSIONS: Diarrheagenic E. coli strains were more frequently isolated in samples from older infants. In this setting with high frequency of pathogen exposure and high frequency of breastfeeding, we hypothesize that the major age-related differences result from decreased exposure to milk-related protective factors and from increased exposure to contaminated food and water.Dr. T. Ochoa is supported by 1K01TW007405; Dr. T. Cleary is supported by R01-HD051716. This work has been partially funded by Dr. C. Lanata's Institutional Research Funds and by the United States Military Infectious Disease Research Program (MIDRP), work unit number 60000.000.0.B0017. The views expressed in this article are those of the author and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, the U.S. Government, nor the National Institutes of Health and other funding institutions. Financial Support: This work has been partially funded by 1K01TW007405 grant (Dr. Ochoa); R01-HD051716 grant (Dr. Cleary); by Dr. Lanata's Institutional Research Funds and by the United States Military Infectious Disease Research Program (MIDRP), work unit number 60000.000.0.B0017.Revisión por paresapplication/pdfengOxford University Presshttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779581/info:eu-repo/semantics/openAccessUniversidad Peruana de Ciencias Aplicadas (UPC)Repositorio Académico - UPCreponame:UPC-Institucionalinstname:Universidad Peruana de Ciencias Aplicadasinstacron:UPCDiarrheagenic E. coliee0071ed-bd37-4964-b78a-c6ab2c31850b600Age-related susceptibility42a81f6f-1fd7-47ad-94cd-c71344017ca7600Diarrhea743dd4de-8a3c-4d82-9a8a-5644c228c88a600Infants1afe27f4-3a57-4513-8202-16aa7137e71b600Perud6e19394-1ad0-4de6-8bb9-5ec7e2e6d476600Age-related susceptibility to infection with diarrheagenic Escherichia coli among infants from Periurban areas in Lima, Peruinfo:eu-repo/semantics/article2018-06-17T22:29:46ZBACKGROUND: Diarrheagenic Escherichia coli strains are being recognized as important pediatric enteropathogens worldwide. However, it is unclear whether there are differences in age-related susceptibility to specific strains, especially among infants. METHODS: We conducted a passive surveillance cohort study of diarrhea that involved 1034 children aged 2-12 months in Lima, Peru. Control stool samples were collected from randomly selected children without diarrhea. All samples were analyzed for common enteric pathogens and for diarrheagenic E. coli with use of multiplex real-time polymerase chain reaction. RESULTS: The most frequently isolated pathogens in 1065 diarrheal episodes were diarrheagenic E. coli strains (31%), including enteroaggregative (15.1%) and enteropathogenic E. coli (7.6%). Diarrheagenic E. coli, Campylobacter species, and rotavirus were more frequently isolated from infants aged >or=6 months. Among older infants, diffusely adherent E. coli and enterotoxigenic E. coli were more frequently isolated from diarrheal samples than from control samples (P <.05). Children aged >or=6 months who were infected with enterotoxigenic E. coli had a 4.56-fold increased risk of diarrhea (95% confidence interval, 1.20-17.28), compared with younger children. Persistent diarrhea was more common in infants aged <6 months (13.5% vs 3.6%; P <.001). Among children with diarrheagenic E. coli-positive samples, coinfections with other pathogens were more common in children with diarrhea than in control children (40.1% vs 15.6%; P <.001). CONCLUSIONS: Diarrheagenic E. coli strains were more frequently isolated in samples from older infants. 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Age-related susceptibility to infection with diarrheagenic Escherichia coli among infants from Periurban areas in Lima, Peru
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