Metabolitos secundarios y actividad inhibitoria de hojas y corteza de Spondias mombin Linn y hojas de Alternanthera lanceolata (Benth.) Schinz sobre α- glucosidasa

• Autores: Tello Lopez, Sally, Tuesta Rios, Kary Jacqueline
• Formato: tesis de grado
• Fecha de Publicación: 2022
• Institución: Universidad Nacional De La Amazonía Peruana
• Repositorio: UNAPIquitos-Institucional
• Lenguaje: español
• OAI Identifier: oai:repositorio.unapiquitos.edu.pe:20.500.12737/8474
• Enlace del recurso: https://hdl.handle.net/20.500.12737/8474
• Nivel de acceso: acceso abierto
• Materia: Extractos vegetales; Metabolitos; Spondias mombin; Alternanthera lanceolata; Inhibición; https://purl.org/pe-repo/ocde/ford#3.01.05

Secondary metabolites (MS) constitute an important source of active ingredients for drugs and chemical products, whose pharmaceutical applications are attributed to their functions as analgesics, antivirals, antibacterials, antioxidants, immunostimulants, among others. The objective of this work was to determine the secondary metabolites and inhibitory activity of leaves and bark of Spondias mombin Linn and leaves of Alternanthera lanceolata (Benth.) Schinz on ? – glucosidase. The MS were measured by spectrophotometry and the inhibitory activity was evaluated at concentrations of 100, 250, 500 and 1000 ug/mL of both extracts, using Acarbose as a positive control, in all millipore water was used as a dilution medium. The results of MS phenolic compounds, alkaloids and saponins show that bark of S. mombin Linn obtained majority results. In the inhibitory activity, Acarbose obtained a higher percentage of inhibition compared to the extracts of S. mombin Linn (leaves and bark) and the extract of A. lanceolata (Benth.) Schinz – leaves; likewise, S. mombin Linn - bark showed an IC50=421.92 ug, compared to S. mombin Linn - leaves with an IC50=898.68 ug and A. lanceolata (Benth.) Schinz – leaves with an IC50=1500.00ug In contrast, the positive control Acarbose obtained a lower IC50=356.80 ug; which allows us to conclude that it is the one with the best inhibitory activity.