Determinación del contenido de compuestos fenólicos y actividad inhibitoria de extractos de Artocarpus altilis (parkinson) Fosberg y Calathea allouia (aubl.) Lindl. sobre α-glucosidasa

• Autores: Romero Rodríguez, María Del Carmen, Curto Arévalo, Jhudy Stefany
• Formato: tesis de grado
• Fecha de Publicación: 2024
• Institución: Universidad Nacional De La Amazonía Peruana
• Repositorio: UNAPIquitos-Institucional
• Lenguaje: español
• OAI Identifier: oai:repositorio.unapiquitos.edu.pe:20.500.12737/10213
• Enlace del recurso: https://hdl.handle.net/20.500.12737/10213
• Nivel de acceso: acceso abierto
• Materia: Compuestos fenólicos; Inhibidores de glicósido hidrolasas; Alfa glucosidasa; Extractos vegetales; Pan de árbol; Artocarpus altilis; Dale dale; Calathea allouia; https://purl.org/pe-repo/ocde/ford#1.06.03

The present study aimed to determine the phenolic compounds and inhibitory activity of ethanolic extracts of Artocarpus altilis (Parkinson) Fosberg (pandisho) and Calathea allouia (Aubl.) Lindl. (dale dale) about α-glucosidase. Samples were collected for convenience, oven-dried, and then micropulverized. Phenolic compounds were quantified using the UV/visible spectrophotometric technique, while the inhibitory activity was from alcoholic extracts at 100, 250, 500 and 1000 µg/mL in reaction mixture on α-glucosidase. The results show that most of the phenolic compounds are present in the leaves of A. altilis with 16278.46 mg/100g of total phenols; 47,987 mg/100g of flavonoids; 13,412 mg/100g of anthocyanins; but, C. allouia (Aubl.) Lindl – tuber obtained 0.007 mg/100g of catechins. In the inhibitory activity, an IC50=887.77 µg was obtained for the A. altilis leaf extract, while the A. altilis bark and C. allouia tuber extracts achieved IC50 > 1000 µg, allowing us to conclude that only the A. altilis leaves are considered active.