Antimicotic effect of thymol on strains of Candida albicans: in vitro study

• Autores: Ayala, J, Jibaja, T, Sotelo, E, Montaño, V, Soler, A, Armas, A
• Formato: artículo
• Fecha de Publicación: 2019
• Institución: Universidad de San Martín de Porres
• Repositorio: Revistas - Universidad de San Martín de Porres
• Lenguaje: español
• OAI Identifier: oai:revistas.usmp.edu.pe:article/1654
• Enlace del recurso: https://portalrevistas.aulavirtualusmp.pe/index.php/Rev-Kiru0/article/view/1654
• Nivel de acceso: acceso abierto
• Materia: Anti-bacterial agents; Candida albicans; Oral candidiasis; Thymol.; Agentes antibacteriales; Candidiasis oral; Timol

Objective: To determine the antimicotic effect of thymol in concentrations of 0.1, 0.5 and 1 % on strains of Candida albicans evaluated at 48 hours of incubation, comparing them with 0.12 % chlorhexidine gluconate and nystatin. Material and methods: Thymol antifungal activity was determined according to the inhibition halo diameter and the susceptibility criteria of the Duraffoourd method, carried out according to the agar diffusion technique with a sample of 25 Petri dishes inoculated with Candida albicans. ATCC®10231, each with 3 filter paper discs embedded in 0.1 %, 0.5 % and 1 % thymol solutions, as in 0.12 % chlorhexidine gluconate and nystatin in suspension following the parameters of National Committee of Standards of Clinical Laboratories. Results: Thymol concentrations of 0.5 and 1% showed an inhibitory effect superior to the substances used as control. Conclusions: Thymol has a greater inhibitory effect than chlorhexidine and nystatin on Candida albicans cells, being shown as an alternative to the usual drugs.