Clinical Practice Guidelines: Diagnostic and Treatment of Multiple Sclerosis in Adults

• Autores: Vizcarra, Darwin R., Cruz, Ana G., Rojas, Edgar, Mori, Nicanor, Caparó, César, Castañeda, Carlos C., Castro, Sheila, Gavidia, Jorge M., González, Oscar, Huertas, Marco, Meza, María, Montalván, Víctor, Rivara, Alda, Adrianzén, Fiorella, Duque, Kevin, Serván, Sebastián A., Villafuerte, Brian J., Vizcarra, Joaquín A., Zamudio, Rodrigo, Neira, Elsa R., Carrá, Adriana, Fernández, Oscar, Rivera, Víctor
• Formato: artículo
• Fecha de Publicación: 2019
• Institución: Universidad Peruana Cayetano Heredia
• Repositorio: Revistas - Universidad Peruana Cayetano Heredia
• Lenguaje: español
• OAI Identifier: oai:revistas.upch.edu.pe:article/3646
• Enlace del recurso: https://revistas.upch.edu.pe/index.php/RNP/article/view/3646
• Nivel de acceso: acceso abierto
• Materia: Multiple sclerosis; practice guideline; Peru.; Esclerosis múltiple; guía de práctica clínica; Perú.

Multiple Sclerosis (MS) is a chronic disease of the central nervous system, for which there is still no definitive cure; but there is a diverse variety of therapies with the objective of modifying the course of the disease, which promotes the constant inclusion of new therapeutic strategies. Objective: The Peruvian Society of Neurology, as requested by the Peruvian Health Ministry, convened a committee of experts with the purpose of elaborating a clinical practice guideline for the diagnosis and treatment of MS. Method: Clinical practice guidelines were searched and evaluated according to the AGREE II methodology, choosing the Catalan Clinical Practice Guide as a model. The clinical questions not related to treatment were solved through a systematic review. The clinical treatment questions were assessed under the PICO format and were solved with a meta-analysis of clinical trials available until August 2017, considering the therapies approved by DIGEMID until January 2017. The final recommendations were elaborated using the modified Delphi method with a consensus of at least 80% of the members of its committee. Finally, an external revision of the manuscript was made by international experts in MS. Results: Eighteen clinical questions and twenty-one recommendations for management were developed, including therapeutic algorithms.