Protective effect of Hylocereus monocanthus on carbon tetrachloride-induced acute hepatotoxicity in rats

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The fruits of Hylocereus monacanthus is considered a promising source of natural antioxidants and are therefore considered a functional and nutraceutical food. The objective of this study was to determine the hepatoprotective activity of ethanolic extract of Hylocereus monacanthus (EEtH) in albino r...

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Autores: Alfaro-Ayvar, Janet Rocio, Inostroza-Ruiz, Luis Alberto, Castro-Luna, Américo Jorge
Formato: artículo
Fecha de Publicación:2022
Institución:Universidad Nacional Mayor de San Marcos
Repositorio:Revistas - Universidad Nacional Mayor de San Marcos
Lenguaje:español
OAI Identifier:oai:ojs.csi.unmsm:article/19744
Enlace del recurso:https://revistasinvestigacion.unmsm.edu.pe/index.php/farma/article/view/19744
Nivel de acceso:acceso abierto
Materia:hepatoprotective activity
induced hepatotoxicity
Hylocereus monacanthus
albino rats
carbon tetrachloride
actividad hepatoprotectora
hepatotoxicidad inducida
ratas albinas
tetracloruro de carbono
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spelling Protective effect of Hylocereus monocanthus on carbon tetrachloride-induced acute hepatotoxicity in ratsEfecto protector de Hylocereus monocanthus en la hepatotoxicidad aguda inducida por tetracloruro de carbono en ratasAlfaro-Ayvar, Janet RocioInostroza-Ruiz, Luis AlbertoCastro-Luna, Américo JorgeAlfaro-Ayvar, Janet RocioInostroza-Ruiz, Luis AlbertoCastro-Luna, Américo Jorgehepatoprotective activityinduced hepatotoxicityHylocereus monacanthusalbino ratscarbon tetrachlorideactividad hepatoprotectorahepatotoxicidad inducidaHylocereus monacanthusratas albinastetracloruro de carbonoThe fruits of Hylocereus monacanthus is considered a promising source of natural antioxidants and are therefore considered a functional and nutraceutical food. The objective of this study was to determine the hepatoprotective activity of ethanolic extract of Hylocereus monacanthus (EEtH) in albino rats with acute carbon tetrachloride-induced toxicity. Phytochemical analysis showed that the fruit of Hylocereus monacanthus contains phenols, flavonoids, among other secondary metabolites; the hepatoprotective activity was evaluated through the biochemical assay of albumin (ALB), direct bilirubin (BD), indirect bilirubin (BI), total bilirubin (BT), alkaline phosphatase (FAL), globulins (GLOB), total proteins (PT) and glutamic oxalacetic transaminase (TGO) in serum and a histopathological study. Treatment with EEtH in albino rats with CCl4-induced hepatotoxicity maintained decreased values of FAL, TGO, BT, BD, BI activity; while PT value remained increased; however, ALB and GLOB values did not undergo significant changes and protected histopathological changes from CCl4. It is concluded that EEtH has a potent hepatoprotective effect on toxic-metabolic lesions such as those caused by CCl4 in albino rats, and this is due to its high antioxidant activity.Los frutos de Hylocereus monacanthus se consideran una fuente prometedora de antioxidantes naturales por lo que es un alimento considerado funcional y nutraceútico. El objetivo de este estudio fue determinar la actividad hepatoprotectora del extracto etanólico del Hylocereus monacanthus (EEtH) en ratas albinas con toxicidad aguda inducida por tetracloruro de carbono. Mediante un análisis fitoquímico se demostró que el fruto de Hylocereus monacanthus contiene fenoles, flavonoides, entre otros metabolitos secundarios; la actividad hepatoprotectora se evaluó a través del ensayo bioquímico de la albumina (ALB), bilirrubina directa (BD), bilirrubina indirecta (BI), bilirrubina total (BT), fosfatasa alcalina (FAL), globulinas (GLOB), proteínas totales (PT) y transaminasa glutámica oxalacética (TGO) en suero y un estudio histopatológico. El tratamiento con EEtH en ratas albinas con hepatotoxicidad inducida por CCl4 mantuvo disminuidos los valores de la actividad de FAL, TGO, BT, BD, BI; mientras que el valor de las PT permaneció incrementado; sin embargo, los valores de la ALB y GLOB no sufrieron cambios significativos y protegió los cambios histopatológicos del CCl4. Se concluye que el EEtH posee potente efecto hepatoprotector sobre lesiones de origen tóxico-metabólico como las provocadas por CCl4 en ratas albinas y se debería a su elevada actividad antioxidante.Universidad Nacional Mayor de San Marcos, Facultad de Farmacia y Bioquímica2022-08-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistasinvestigacion.unmsm.edu.pe/index.php/farma/article/view/1974410.15381/ci.v25i1.19744Ciencia e Investigación; Vol. 25 Núm. 1 (2022); 3-9Ciencia e Investigación; Vol. 25 No. 1 (2022); 3-91609-90441561-0861reponame:Revistas - Universidad Nacional Mayor de San Marcosinstname:Universidad Nacional Mayor de San Marcosinstacron:UNMSMspahttps://revistasinvestigacion.unmsm.edu.pe/index.php/farma/article/view/19744/18691Derechos de autor 2022 Janet Rocio Alfaro-Ayvar, Luis Alberto Inostroza-Ruiz, Américo Jorge Castro-Lunahttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessoai:ojs.csi.unmsm:article/197442022-09-08T21:02:09Z
dc.title.none.fl_str_mv Protective effect of Hylocereus monocanthus on carbon tetrachloride-induced acute hepatotoxicity in rats
Efecto protector de Hylocereus monocanthus en la hepatotoxicidad aguda inducida por tetracloruro de carbono en ratas
title Protective effect of Hylocereus monocanthus on carbon tetrachloride-induced acute hepatotoxicity in rats
spellingShingle Protective effect of Hylocereus monocanthus on carbon tetrachloride-induced acute hepatotoxicity in rats
Alfaro-Ayvar, Janet Rocio
hepatoprotective activity
induced hepatotoxicity
Hylocereus monacanthus
albino rats
carbon tetrachloride
actividad hepatoprotectora
hepatotoxicidad inducida
Hylocereus monacanthus
ratas albinas
tetracloruro de carbono
title_short Protective effect of Hylocereus monocanthus on carbon tetrachloride-induced acute hepatotoxicity in rats
title_full Protective effect of Hylocereus monocanthus on carbon tetrachloride-induced acute hepatotoxicity in rats
title_fullStr Protective effect of Hylocereus monocanthus on carbon tetrachloride-induced acute hepatotoxicity in rats
title_full_unstemmed Protective effect of Hylocereus monocanthus on carbon tetrachloride-induced acute hepatotoxicity in rats
title_sort Protective effect of Hylocereus monocanthus on carbon tetrachloride-induced acute hepatotoxicity in rats
dc.creator.none.fl_str_mv Alfaro-Ayvar, Janet Rocio
Inostroza-Ruiz, Luis Alberto
Castro-Luna, Américo Jorge
Alfaro-Ayvar, Janet Rocio
Inostroza-Ruiz, Luis Alberto
Castro-Luna, Américo Jorge
author Alfaro-Ayvar, Janet Rocio
author_facet Alfaro-Ayvar, Janet Rocio
Inostroza-Ruiz, Luis Alberto
Castro-Luna, Américo Jorge
author_role author
author2 Inostroza-Ruiz, Luis Alberto
Castro-Luna, Américo Jorge
author2_role author
author
dc.subject.none.fl_str_mv hepatoprotective activity
induced hepatotoxicity
Hylocereus monacanthus
albino rats
carbon tetrachloride
actividad hepatoprotectora
hepatotoxicidad inducida
Hylocereus monacanthus
ratas albinas
tetracloruro de carbono
topic hepatoprotective activity
induced hepatotoxicity
Hylocereus monacanthus
albino rats
carbon tetrachloride
actividad hepatoprotectora
hepatotoxicidad inducida
Hylocereus monacanthus
ratas albinas
tetracloruro de carbono
description The fruits of Hylocereus monacanthus is considered a promising source of natural antioxidants and are therefore considered a functional and nutraceutical food. The objective of this study was to determine the hepatoprotective activity of ethanolic extract of Hylocereus monacanthus (EEtH) in albino rats with acute carbon tetrachloride-induced toxicity. Phytochemical analysis showed that the fruit of Hylocereus monacanthus contains phenols, flavonoids, among other secondary metabolites; the hepatoprotective activity was evaluated through the biochemical assay of albumin (ALB), direct bilirubin (BD), indirect bilirubin (BI), total bilirubin (BT), alkaline phosphatase (FAL), globulins (GLOB), total proteins (PT) and glutamic oxalacetic transaminase (TGO) in serum and a histopathological study. Treatment with EEtH in albino rats with CCl4-induced hepatotoxicity maintained decreased values of FAL, TGO, BT, BD, BI activity; while PT value remained increased; however, ALB and GLOB values did not undergo significant changes and protected histopathological changes from CCl4. It is concluded that EEtH has a potent hepatoprotective effect on toxic-metabolic lesions such as those caused by CCl4 in albino rats, and this is due to its high antioxidant activity.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-31
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://revistasinvestigacion.unmsm.edu.pe/index.php/farma/article/view/19744
10.15381/ci.v25i1.19744
url https://revistasinvestigacion.unmsm.edu.pe/index.php/farma/article/view/19744
identifier_str_mv 10.15381/ci.v25i1.19744
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://revistasinvestigacion.unmsm.edu.pe/index.php/farma/article/view/19744/18691
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Nacional Mayor de San Marcos, Facultad de Farmacia y Bioquímica
publisher.none.fl_str_mv Universidad Nacional Mayor de San Marcos, Facultad de Farmacia y Bioquímica
dc.source.none.fl_str_mv Ciencia e Investigación; Vol. 25 Núm. 1 (2022); 3-9
Ciencia e Investigación; Vol. 25 No. 1 (2022); 3-9
1609-9044
1561-0861
reponame:Revistas - Universidad Nacional Mayor de San Marcos
instname:Universidad Nacional Mayor de San Marcos
instacron:UNMSM
instname_str Universidad Nacional Mayor de San Marcos
instacron_str UNMSM
institution UNMSM
reponame_str Revistas - Universidad Nacional Mayor de San Marcos
collection Revistas - Universidad Nacional Mayor de San Marcos
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 13.87115
Protective effect of Hylocereus monocanthus on carbon tetrachloride-induced acute hepatotoxicity in rats
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