¿Nos encontramos frente a una nueva clase de mutagenos?

• Autores: Cuyubamba, Oscar R., Pryor, William, Shane, Barbara S., Squadrito, Giuseppe
• Formato: artículo
• Fecha de Publicación: 1990
• Institución: Pontificia Universidad Católica del Perú
• Repositorio: Revistas - Pontificia Universidad Católica del Perú
• Lenguaje: español
• OAI Identifier: oai:revistaspuc:article/5636
• Enlace del recurso: http://revistas.pucp.edu.pe/index.php/quimica/article/view/5636
• Nivel de acceso: acceso abierto
• Materia: Biology; ADN; Biologia

1,3-Dinitronaphthalene, previous1y identified in particulate organic matter, easily forms covalent adducts with DNA nucleotides at room temperature. The mutagenic potency of a related dinitropolycyclic aromatic hydrocarbon (dinitroPAH) with meta disubstitution, namely 1,3-dinitrofluoranthene, is rather independent of the Salmonella Typhimurium tester strain (TA98, TA98NR and TA98/l, 8DNP6) when assayed according to the Ames Test. This unusual behavior suggests that it does not require metabolic activation via the "classical nitroreductase" and/or the acetylase. The fact that 1,3--dinitronaphthalene readily forms covalent adducts with DNA nucleotides further suggests that dinitroPAH with meta nitro-groups may not require the usual metabolic activation pathways.