RISK FACTORS ASSOCIATED WITH THE DEVELOPMENT OF HELLP SYNDROME IN PREGNANT WOMEN TREATED AT THE NATIONAL MATERNAL INSTITUTE PERINATAL, LIMA, 2018-2021: A CASE REPORT

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We present an unusual case of birth of a neonate with complex chromosomal rearrangement type apparently balanced three-way translocation, The neonate presented with karyotype 46, XY t(3; 12; 15)(q12; q13; q15) de novo, with dysmorphic features, such as low ear implantation, redundant skin on the nec...

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Detalles Bibliográficos
Autor: Rojas-Vargas, Sofia
Formato: artículo
Fecha de Publicación:2024
Institución:Instituto Nacional Materno Perinatal
Repositorio:Revista Peruana de Investigación Materno Perinatal
Lenguaje:español
OAI Identifier:oai:ojs.www.fracturae.com:article/374
Enlace del recurso:https://investigacionmaternoperinatal.inmp.gob.pe/index.php/rpinmp/article/view/374
Nivel de acceso:acceso abierto
Materia:Síndrome HELLP
Complex chromosomal rearrangements
three-way translocation
dysmorphia
congenital defects
karyotype
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network_name_str Revista Peruana de Investigación Materno Perinatal
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spelling RISK FACTORS ASSOCIATED WITH THE DEVELOPMENT OF HELLP SYNDROME IN PREGNANT WOMEN TREATED AT THE NATIONAL MATERNAL INSTITUTE PERINATAL, LIMA, 2018-2021: A CASE REPORTFACTORES DE RIESGO ASOCIADOS EN EL DESARROLLO DE SÍNDROME HELLP EN GESTANTES ATENDIDAS EN EL INSTITUTO NACIONAL MATERNO PERINATAL, LIMA, 2018-2021: A CASE REPORTRojas-Vargas, SofiaSíndrome HELLPComplex chromosomal rearrangementsthree-way translocationdysmorphiacongenital defectskaryotypeWe present an unusual case of birth of a neonate with complex chromosomal rearrangement type apparently balanced three-way translocation, The neonate presented with karyotype 46, XY t(3; 12; 15)(q12; q13; q15) de novo, with dysmorphic features, such as low ear implantation, redundant skin on the neck , micropenis,  congenital heart disease with anatomical variant without functional alteration who was born and evaluated at our institution. This type of rearrangement is usually related to conditions other than congenital malformations, such as hematological disorders, and in phenotypically normal carriers with fertility problems; therefore, it is important to carry out a thorough follow-up of the patient due to possible complications in their psychomotor development and adequate genetic counseling to family members.Objetivo. Determinar los factores de riesgo en el desarrollo de Síndrome HELLP en gestantes atendidas en el Instituto Nacional Materno Perinatal, 2018-2021. Materiales y métodos. Estudio retrospectivo de corte transversal con diseño de casos y controles. Se recopilaron 2500 historias clínicas, seleccionando 196 participantes: 98 casos y 98 controles, siguiendo criterios de elegibilidad. Se utilizó una ficha de recolección de datos con variables y dimensiones del estudio. Para el análisis, se empleó SPSS, aplicando técnicas de frecuencia y pruebas de Chi cuadrado de Pearson para evaluar las asociaciones. Resultados. En los casos de síndrome de HELLP, la mayor prevalencia se observó en mujeres solteras y convivientes, representando un 16,8% (p = 0,583). El 20,4% de las mujeres con nivel educativo primario presentaban esta condición (p = 0,195). El 12,2% de los casos correspondía a mujeres entre 30 y 32 años (p = 0,640). Se encontró una mayor proporción de casos en mujeres con antecedentes de hipertensión arterial (29,1%, OR: 1,23) y en aquellas con desnutrición (27,6%, OR: 1,78). No se encontró una asociación significativa con la paridad, aunque se observó una mayor frecuencia de casos en mujeres nulíparas (17,9%, OR: 1,53) y en gestantes con una edad gestacional de 40 semanas (6,1%). Conclusiones. La desnutrición es un factor de riesgo asociado al desarrollo de Síndrome HELLP.Instituto Nacional Materno Perinatal (INMP), Lima - Perú.2024-11-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://investigacionmaternoperinatal.inmp.gob.pe/index.php/rpinmp/article/view/37410.33421/inmp.2024374Revista Peruana de Investigación Materno Perinatal; Vol. 13 No. 1 (2024): Revista Peruana de Investigación Materno PerinatalRevista Peruana de Investigación Materno Perinatal; Vol. 13 Núm. 1 (2024): Revista Peruana de Investigación Materno Perinatal2663-113X2305-3887reponame:Revista Peruana de Investigación Materno Perinatalinstname:Instituto Nacional Materno Perinatalinstacron:INMPspahttps://investigacionmaternoperinatal.inmp.gob.pe/index.php/rpinmp/article/view/374/378Derechos de autor 2024 Revista Peruana de Investigación Materno Perinatalhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessoai:ojs.www.fracturae.com:article/3742025-01-16T16:09:37Z
dc.title.none.fl_str_mv RISK FACTORS ASSOCIATED WITH THE DEVELOPMENT OF HELLP SYNDROME IN PREGNANT WOMEN TREATED AT THE NATIONAL MATERNAL INSTITUTE PERINATAL, LIMA, 2018-2021: A CASE REPORT
FACTORES DE RIESGO ASOCIADOS EN EL DESARROLLO DE SÍNDROME HELLP EN GESTANTES ATENDIDAS EN EL INSTITUTO NACIONAL MATERNO PERINATAL, LIMA, 2018-2021: A CASE REPORT
title RISK FACTORS ASSOCIATED WITH THE DEVELOPMENT OF HELLP SYNDROME IN PREGNANT WOMEN TREATED AT THE NATIONAL MATERNAL INSTITUTE PERINATAL, LIMA, 2018-2021: A CASE REPORT
spellingShingle RISK FACTORS ASSOCIATED WITH THE DEVELOPMENT OF HELLP SYNDROME IN PREGNANT WOMEN TREATED AT THE NATIONAL MATERNAL INSTITUTE PERINATAL, LIMA, 2018-2021: A CASE REPORT
Rojas-Vargas, Sofia
Síndrome HELLP
Complex chromosomal rearrangements
three-way translocation
dysmorphia
congenital defects
karyotype
title_short RISK FACTORS ASSOCIATED WITH THE DEVELOPMENT OF HELLP SYNDROME IN PREGNANT WOMEN TREATED AT THE NATIONAL MATERNAL INSTITUTE PERINATAL, LIMA, 2018-2021: A CASE REPORT
title_full RISK FACTORS ASSOCIATED WITH THE DEVELOPMENT OF HELLP SYNDROME IN PREGNANT WOMEN TREATED AT THE NATIONAL MATERNAL INSTITUTE PERINATAL, LIMA, 2018-2021: A CASE REPORT
title_fullStr RISK FACTORS ASSOCIATED WITH THE DEVELOPMENT OF HELLP SYNDROME IN PREGNANT WOMEN TREATED AT THE NATIONAL MATERNAL INSTITUTE PERINATAL, LIMA, 2018-2021: A CASE REPORT
title_full_unstemmed RISK FACTORS ASSOCIATED WITH THE DEVELOPMENT OF HELLP SYNDROME IN PREGNANT WOMEN TREATED AT THE NATIONAL MATERNAL INSTITUTE PERINATAL, LIMA, 2018-2021: A CASE REPORT
title_sort RISK FACTORS ASSOCIATED WITH THE DEVELOPMENT OF HELLP SYNDROME IN PREGNANT WOMEN TREATED AT THE NATIONAL MATERNAL INSTITUTE PERINATAL, LIMA, 2018-2021: A CASE REPORT
dc.creator.none.fl_str_mv Rojas-Vargas, Sofia
author Rojas-Vargas, Sofia
author_facet Rojas-Vargas, Sofia
author_role author
dc.subject.none.fl_str_mv Síndrome HELLP
Complex chromosomal rearrangements
three-way translocation
dysmorphia
congenital defects
karyotype
topic Síndrome HELLP
Complex chromosomal rearrangements
three-way translocation
dysmorphia
congenital defects
karyotype
description We present an unusual case of birth of a neonate with complex chromosomal rearrangement type apparently balanced three-way translocation, The neonate presented with karyotype 46, XY t(3; 12; 15)(q12; q13; q15) de novo, with dysmorphic features, such as low ear implantation, redundant skin on the neck , micropenis,  congenital heart disease with anatomical variant without functional alteration who was born and evaluated at our institution. This type of rearrangement is usually related to conditions other than congenital malformations, such as hematological disorders, and in phenotypically normal carriers with fertility problems; therefore, it is important to carry out a thorough follow-up of the patient due to possible complications in their psychomotor development and adequate genetic counseling to family members.
publishDate 2024
dc.date.none.fl_str_mv 2024-11-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://investigacionmaternoperinatal.inmp.gob.pe/index.php/rpinmp/article/view/374
10.33421/inmp.2024374
url https://investigacionmaternoperinatal.inmp.gob.pe/index.php/rpinmp/article/view/374
identifier_str_mv 10.33421/inmp.2024374
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://investigacionmaternoperinatal.inmp.gob.pe/index.php/rpinmp/article/view/374/378
dc.rights.none.fl_str_mv Derechos de autor 2024 Revista Peruana de Investigación Materno Perinatal
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Derechos de autor 2024 Revista Peruana de Investigación Materno Perinatal
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Instituto Nacional Materno Perinatal (INMP), Lima - Perú.
publisher.none.fl_str_mv Instituto Nacional Materno Perinatal (INMP), Lima - Perú.
dc.source.none.fl_str_mv Revista Peruana de Investigación Materno Perinatal; Vol. 13 No. 1 (2024): Revista Peruana de Investigación Materno Perinatal
Revista Peruana de Investigación Materno Perinatal; Vol. 13 Núm. 1 (2024): Revista Peruana de Investigación Materno Perinatal
2663-113X
2305-3887
reponame:Revista Peruana de Investigación Materno Perinatal
instname:Instituto Nacional Materno Perinatal
instacron:INMP
instname_str Instituto Nacional Materno Perinatal
instacron_str INMP
institution INMP
reponame_str Revista Peruana de Investigación Materno Perinatal
collection Revista Peruana de Investigación Materno Perinatal
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1841715590795886592
score 13.4721
RISK FACTORS ASSOCIATED WITH THE DEVELOPMENT OF HELLP SYNDROME IN PREGNANT WOMEN TREATED AT THE NATIONAL MATERNAL INSTITUTE PERINATAL, LIMA, 2018-2021: A CASE REPORT
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