Genetic mutations that confer resistance to Isoniazid in patients with Tuberculosis in Lima Centro, Perú 2017- 2018

• Autores: Vargas-Ponce, Kenneth G., Trujillo-Valencia, Claudia L., Saravia-Ruiz, Trilce, Salas-López, Juan A., Llanos-Tejada, Félix K.
• Formato: artículo
• Fecha de Publicación: 2021
• Institución: Colegio Médico del Perú
• Repositorio: Acta Médica Peruana
• Lenguaje: español
• OAI Identifier: oai:amp.cmp.org.pe:article/1892
• Enlace del recurso: https://amp.cmp.org.pe/index.php/AMP/article/view/1892
• Nivel de acceso: acceso abierto
• Materia: Mycobacterium tuberculosis; Tuberculosis resistente a múltiples medicamentos; Mutación; Isoniacida; Perú; Tuberculosis; Multidrug-Resistant; Mutation; Isoniazid

This a report of the frequency of KatG and inhA genetic mutations that confer resistance to isoniazid in a sample of 777 patients with resistance to isoniazid. GenoType® MTBDRplus test and conventional sensitivity tests by the agar plate method were used. It was found that 54% presented mutation in the KatG gene, associated with higher resistance to streptomycin 76.6% (p <0.05), rifampicin 66.7% (p <0.05) and ethionamide in 33% (p <0.05). inhA gene mutation has a frequency of 46% and was associated with resistance to ethionamide in 68.1% (p <0.05), rifampicin 47.2% (p <0.05) and streptomycin 33% (p <0.05). In this sample, the presences of mutations that confer resistance to isoniazid was associated with resistance to other antituberculosis drugs.