El objetivo de este trabajo es conocer cómo se realizaron las actividades del internado medico en el Instituto Nacional de Enfermedades Neoplásicas en el año 2020-2021, periodo pre-pandemia y durante la pandemia, cuáles fueron las expectativas y realidades que se encontraron frente a esta transición y como es que esto afecto en la formación médica. Se analizo la importancia que le daba el interno de medicina al último año de la cerrera profesional, el desarrollo de actividades por cada rotación en un contexto diferente al de años anteriores y cuáles fueron las dificultades encontradas. Los principales hallazgos fueron que el interno de medicina cataloga al último año de la profesión como una etapa imprescindible para el desarrollo de habilidades y formación médica. Que el internado debería ser reestructurado en cuanto al marco legal, ya que cuenta con muchos vacíos y n...

This a report of the frequency of KatG and inhA genetic mutations that confer resistance to isoniazid in a sample of 777 patients with resistance to isoniazid. GenoType® MTBDRplus test and conventional sensitivity tests by the agar plate method were used. It was found that 54% presented mutation in the KatG gene, associated with higher resistance to streptomycin 76.6% (p <0.05), rifampicin 66.7% (p <0.05) and ethionamide in 33% (p <0.05). inhA gene mutation has a frequency of 46% and was associated with resistance to ethionamide in 68.1% (p <0.05), rifampicin 47.2% (p <0.05) and streptomycin 33% (p <0.05). In this sample, the presences of mutations that confer resistance to isoniazid was associated with resistance to other antituberculosis drugs.

This a report of the frequency of KatG and inhA genetic mutations that confer resistance to isoniazid in a sample of 777 patients with resistance to isoniazid. GenoType® MTBDRplus test and conventional sensitivity tests by the agar plate method were used. It was found that 54% presented mutation in the KatG gene, associated with higher resistance to streptomycin 76.6% (p <0.05), rifampicin 66.7% (p <0.05) and ethionamide in 33% (p <0.05). inhA gene mutation has a frequency of 46% and was associated with resistance to ethionamide in 68.1% (p <0.05), rifampicin 47.2% (p <0.05) and streptomycin 33% (p <0.05). In this sample, the presences of mutations that confer resistance to isoniazid was associated with resistance to other antituberculosis drugs.