Morphological alterations of the bone marrow in patients with COVID-19. Systematic review and meta-analysis

• Autores: Pichardo-Rodriguez, Rafael, Cordova-Cueva, Liz, Peña-Oscuvilca, Willy, Bracamonte-Hernández, Juan Jesús, Carrasco-Vergaray, Carlos, Saavedra-Velasco, Marcos, Ruiz-Franco, Oscar
• Formato: artículo
• Fecha de Publicación: 2022
• Institución: Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
• Repositorio: Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
• Lenguaje: español
• OAI Identifier: oai:cmhnaaa_ojs_cmhnaaa.cmhnaaa.org.pe:article/1479
• Enlace del recurso: https://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/1479
• Nivel de acceso: acceso abierto
• Materia: Médula Ósea; Hematopoyesis; COVID-19; SARS-CoV-2; Metaanálisis; Revisión Sistemática; Bone Marrow; Hematopoiesis; Meta-Analysis; Systematic Review

Introduction: Despite the fact that hematological alterations at the peripheral level are widely known, little is known about the alterations caused by COVID-19 at the bone marrow level. Objective: To determine the morphological alterations of the bone marrow caused by COVID-19. Material and methods: Systematic review and meta-analysis. Observational studies and reports and case series were included and editorials, reviews, letters to the editor were excluded. A search was performed in Pubmed, ScienceDirect and Scielo. The risk of bias was assessed using the NewCatell-Ottawa and Hassan Murad scales for case reports and series. The outcomes were the morphological parameters of the bone marrow. For the quantitative synthesis of the information, a proportion meta-analysis was performed using random effects in RStudio. Results: Hypercellularity occurred in 65% (95% CI: 51%-78%), maturation arrest of the myeloid series occurred in 57% (95% CI: 29%-83%). and the alteration of the M/E ratio occurred in 60% (95% CI: 46%-74%). Conclusion: The most frequent morphological alterations in the bone marrow were hypercellularity, arrest in myeloid maturation and alteration of the M/E ratio in patients with COVID-19.