Introducción: en Amazonas, Perú, se llevó a cabo el Plan Nacional de Vacunación (PNV) contra el COVID-19, utilizando vacunas con eficacia y seguridad. Sin embargo, su efectividad en condiciones reales era desconocida Objetivo: estimar la efectividad del programa de vacunación AntiCOVID-19 en prevenir hospitalizaciones, enfermedad grave y muertes por COVID-19 entre el 10 de febrero del 2021 y el 28 de enero del 2023 en Amazonas, Perú. Métodos: se realizó estudio observacional, analítico y de cohorte retrospectivo, en el cual se examinaron datos de 35,268 individuos de 18 años en adelante. Los datos fueron recopilados desde el 10 de febrero de 2021 hasta el 28 de enero de 2023, utilizando fuentes secundarias de información. Los participantes fueron aquellos admitidos en el PNV y se dividieron en dos cohortes: aquellos que no estaban vacunados contra la COVID-19 y aquellos que sÃ...

Introduction: Case reports are a type of biomedical publication that allow us to share experiences regarding the etiology, diagnosis, therapeutics, and prognosis of anecdotal events that occur both in one and in several patients during clinical practice. Objective: to elaborate methodological recommendations for the elaboration of the discussion of a clinical case report. Methods: A narrative review of international guidelines and available evidence was carried out. Results: A total of 411,227 articles were located, finally selecting 10 narrative review articles. Discussion: The discussion is the most relevant section of the case report despite being considered by some journals as an optional contribution. We recommend for the elaboration of the discussion, to follow the following four steps: a) finding and comparison with the current evidence, b) justification of the causality of the fi...

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Systemic or cutaneous-visceral loxoscelism is the most severe clinical presentation of loxoscelism. Currently there is no validated laboratory diagnostic method that allows us to confirm the presence of this disease in the face of arachneism. However, there is a clinical prediction rule (CPR), which allows us to predict the evolution of a bite towards a systemic condition and which would be useful in emergency rooms. We present the case of a woman who developed the systemic picture of loxoscelism to whom a new CPR was applied for the early detection of systemic loxoscelism, presenting adequate performance for early evaluation in emergency services.

Introduction: Despite the fact that hematological alterations at the peripheral level are widely known, little is known about the alterations caused by COVID-19 at the bone marrow level. Objective: To determine the morphological alterations of the bone marrow caused by COVID-19. Material and methods: Systematic review and meta-analysis. Observational studies and reports and case series were included and editorials, reviews, letters to the editor were excluded. A search was performed in Pubmed, ScienceDirect and Scielo. The risk of bias was assessed using the NewCatell-Ottawa and Hassan Murad scales for case reports and series. The outcomes were the morphological parameters of the bone marrow. For the quantitative synthesis of the information, a proportion meta-analysis was performed using random effects in RStudio. Results: Hypercellularity occurred in 65% (95% CI: 51%-78%), maturation a...