Prognostic factors for patients with newly diagnosed brain metastasis from breast cancer

• Autores: Castaneda, Carlos, Flores, R, Castillo, Miluska, Rojas, KY, Castillo, M, Dolores-Cerna, K, Flores, C, Belmar-Lopez, C, Milla, E, Gomez, HL
• Formato: artículo
• Fecha de Publicación: 2015
• Institución: Instituto Nacional de Enfermedades Neoplásicas
• Repositorio: INEN-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorio.inen.sld.pe:inen/66
• Enlace del recurso: https://repositorio.inen.sld.pe/handle/inen/66
• Nivel de acceso: acceso abierto
• Materia: Dspace; Open access; Repositorio digital; https://purl.org/pe-repo/ocde/ford#3.02.21

Aim: This retrospective study determined features associated with brain metastasis (BM) in women with breast cancer. Patients & methods: A total of 215 initially early breast cancer cases were included. We reviewed files and CT scan images of BM. Results: Median age was 47 years and most of our cases were stage III (58.6%), grade III (62.8%), ER negative (62.3%) and nonluminal (59.1%). Median survival after BM was 4 months. Nonluminal, extracranial disease, time to CNS shorter than 15 months, >three brain lesions and poor breast-graded prognostic assessment and recursive partitioning analysis scores were associated with shorter survival. Adding extracranial disease to breast-graded prognostic assessment score also predicted survival after BM. Radiation response was assessed in 57 patients and response tended to be associated with nonluminal phenotype but not with survival. Conclusion: Factors associated with both initial tumor and clinical features at BM time are associated with shorter survival in our Latinas population.