HTLV- I infection is not associated with a higher risk of death in peruvian HIV- infected patients
Descripción del Articulo
Existe información limitada y contradictoria sobre el pronóstico de la coinfección del Virus de Inmunodeficiencia Humana (VIH) y el Virus Linfotrópico T Humano tipo 1 (HTLV-1), por este motivo se realizó un estudio para estimar el efecto de la infección por HTLV-1 en la mortalidad de pacientes infec...
| Autores: | , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2009 |
| Institución: | Seguro Social de Salud |
| Repositorio: | ESSALUD-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.essalud.gob.pe:20.500.12959/405 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12959/405 https://doi.org/10.1590/S0036-46652009000400004 |
| Nivel de acceso: | acceso abierto |
| Materia: | Enfermedades Infecciosas VIH Virus 1 Linfotrópico T Humano Mortalidad HIV/HTLV-I co-infection Death https://purl.org/pe-repo/ocde/ford#3.05.00 |
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| dc.title.es_PE.fl_str_mv |
HTLV- I infection is not associated with a higher risk of death in peruvian HIV- infected patients |
| title |
HTLV- I infection is not associated with a higher risk of death in peruvian HIV- infected patients |
| spellingShingle |
HTLV- I infection is not associated with a higher risk of death in peruvian HIV- infected patients Collins, Jaime A. Enfermedades Infecciosas VIH Virus 1 Linfotrópico T Humano Mortalidad HIV/HTLV-I co-infection Death https://purl.org/pe-repo/ocde/ford#3.05.00 |
| title_short |
HTLV- I infection is not associated with a higher risk of death in peruvian HIV- infected patients |
| title_full |
HTLV- I infection is not associated with a higher risk of death in peruvian HIV- infected patients |
| title_fullStr |
HTLV- I infection is not associated with a higher risk of death in peruvian HIV- infected patients |
| title_full_unstemmed |
HTLV- I infection is not associated with a higher risk of death in peruvian HIV- infected patients |
| title_sort |
HTLV- I infection is not associated with a higher risk of death in peruvian HIV- infected patients |
| author |
Collins, Jaime A. |
| author_facet |
Collins, Jaime A. Hernández, Adrián V. Hidalgo, José A. Salazar, Raúl Almenara Hospital AIDS Working Group |
| author_role |
author |
| author2 |
Hernández, Adrián V. Hidalgo, José A. Salazar, Raúl Almenara Hospital AIDS Working Group |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Collins, Jaime A. Hernández, Adrián V. Hidalgo, José A. Salazar, Raúl Almenara Hospital AIDS Working Group |
| dc.subject.es_PE.fl_str_mv |
Enfermedades Infecciosas VIH Virus 1 Linfotrópico T Humano Mortalidad |
| topic |
Enfermedades Infecciosas VIH Virus 1 Linfotrópico T Humano Mortalidad HIV/HTLV-I co-infection Death https://purl.org/pe-repo/ocde/ford#3.05.00 |
| dc.subject.none.fl_str_mv |
HIV/HTLV-I co-infection Death |
| dc.subject.ocde.es_PE.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#3.05.00 |
| description |
Existe información limitada y contradictoria sobre el pronóstico de la coinfección del Virus de Inmunodeficiencia Humana (VIH) y el Virus Linfotrópico T Humano tipo 1 (HTLV-1), por este motivo se realizó un estudio para estimar el efecto de la infección por HTLV-1 en la mortalidad de pacientes infectados con VIH en la Unidad de VIH/SIDA del Hospital Nacional Guillermo Almenara, en Lima, Perú. Se estudió una cohorte retrospectiva de pacientes infectados por el VIH, que estuvieron expuestos o no al HTLV-1, entre enero 1990 a junio 2004. El estudio concluye que la infección de HTLV-1 no estaba asociada con un riesgo alto de muerte de pacientes peruanos infectados con el virus de VIH. El exceso de mortalidad en esta población se puede explicar con la infección avanzada de VIH y la ausencia de terapia antirretroviral. |
| publishDate |
2009 |
| dc.date.accessioned.none.fl_str_mv |
2019-04-24T13:52:35Z |
| dc.date.available.none.fl_str_mv |
2019-04-24T13:52:35Z |
| dc.date.issued.fl_str_mv |
2009 |
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info:eu-repo/semantics/article |
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article |
| dc.identifier.citation.es_PE.fl_str_mv |
Revista do Instituto de Medicina Tropical de Sao Paulo. 2009;51(4). |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12959/405 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1590/S0036-46652009000400004 |
| identifier_str_mv |
Revista do Instituto de Medicina Tropical de Sao Paulo. 2009;51(4). |
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https://hdl.handle.net/20.500.12959/405 https://doi.org/10.1590/S0036-46652009000400004 |
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eng |
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eng |
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https://www.scielo.br/j/rimtsp/a/ndbJmRSDckPYN5qXk5VrnPp/?lang=en |
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info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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application/pdf |
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Instituto de Medicina Tropical de São Paulo |
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PE |
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Seguro Social de Salud (EsSalud) Repositorio Institucional EsSalud |
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Collins, Jaime A.Hernández, Adrián V.Hidalgo, José A.Salazar, RaúlAlmenara Hospital AIDS Working Group2019-04-24T13:52:35Z2019-04-24T13:52:35Z2009Revista do Instituto de Medicina Tropical de Sao Paulo. 2009;51(4).https://hdl.handle.net/20.500.12959/405https://doi.org/10.1590/S0036-46652009000400004Existe información limitada y contradictoria sobre el pronóstico de la coinfección del Virus de Inmunodeficiencia Humana (VIH) y el Virus Linfotrópico T Humano tipo 1 (HTLV-1), por este motivo se realizó un estudio para estimar el efecto de la infección por HTLV-1 en la mortalidad de pacientes infectados con VIH en la Unidad de VIH/SIDA del Hospital Nacional Guillermo Almenara, en Lima, Perú. Se estudió una cohorte retrospectiva de pacientes infectados por el VIH, que estuvieron expuestos o no al HTLV-1, entre enero 1990 a junio 2004. El estudio concluye que la infección de HTLV-1 no estaba asociada con un riesgo alto de muerte de pacientes peruanos infectados con el virus de VIH. El exceso de mortalidad en esta población se puede explicar con la infección avanzada de VIH y la ausencia de terapia antirretroviral.Limited and contradictory information exists regarding the prognosis of HIV/HTLV-I co-infection. Our goal was to estimate the effect of HTLV-I infection on mortality in HIV-infected patients at a HIV reference center in Peru. We studied a retrospective cohort of HIV-infected patients, who were exposed or unexposed to HTLV-I. Exposed patients were Western Blot (WB) positive for both retroviruses. Unexposed patients were WB positive for HIV, and had least one negative EIA for HTLV-I. These were selected among patients who entered our Program immediately before and after each exposed patient, between January 1990 and June 2004. Survival time was considered between the diagnosis of exposure to HTLV-I and death or censoring. Confounding variables were age, gender, baseline HIV clinical stage, baseline CD4+ T cell count, and antiretroviral therapy. We studied 50 exposed, and 100 unexposed patients. Exposed patients had a shorter survival compared to unexposed patients [median survival: 47 months (95% CI: 17-77) vs. 85 months (95% CI: 70-100), unadjusted p = 0.06]. Exposed patients had a higher rate of mortality compared to unexposed patients (HIV/HTLV-I (24/50 [48%]) vs. HIV only (37/100 [37%]), univariable p = 0.2]. HTLV-I exposure was not associated to a higher risk of death in the adjusted analysis: HR: 1.2 (0.4-3.5). AIDS clinical stage and lack of antiretroviral therapy were associated to a higher risk of dying. In conclusions, HTLV-I infection was not associated with a higher risk of death in Peruvian HIV-infected patients. Advanced HIV infection and lack of antiretroviral therapy may explain the excess of mortality in this population.application/pdfengInstituto de Medicina Tropical de São PauloPEhttps://www.scielo.br/j/rimtsp/a/ndbJmRSDckPYN5qXk5VrnPp/?lang=eninfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/Seguro Social de Salud (EsSalud)Repositorio Institucional EsSaludreponame:ESSALUD-Institucionalinstname:Seguro Social de Saludinstacron:ESSALUDEnfermedades InfecciosasVIHVirus 1 Linfotrópico T HumanoMortalidadHIV/HTLV-I co-infectionDeathhttps://purl.org/pe-repo/ocde/ford#3.05.00HTLV- I infection is not associated with a higher risk of death in peruvian HIV- infected patientsinfo:eu-repo/semantics/articleORIGINALHTLV-I infection is not associated with a higher risk of death in Peruvian HIV-infected patients.pdfHTLV-I infection is not associated with a higher risk of death in Peruvian HIV-infected patients.pdfapplication/pdf145218https://repositorio.essalud.gob.pe/bitstream/20.500.12959/405/1/HTLV-I%20infection%20is%20not%20associated%20with%20a%20higher%20risk%20of%20death%20in%20Peruvian%20HIV-infected%20patients.pdfa4724316d414bd3a329fb448784fd792MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.essalud.gob.pe/bitstream/20.500.12959/405/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTHTLV-I infection is not associated with a higher risk of death in Peruvian HIV-infected patients.pdf.txtHTLV-I infection is not associated with a higher risk of death in Peruvian HIV-infected patients.pdf.txtExtracted texttext/plain25347https://repositorio.essalud.gob.pe/bitstream/20.500.12959/405/3/HTLV-I%20infection%20is%20not%20associated%20with%20a%20higher%20risk%20of%20death%20in%20Peruvian%20HIV-infected%20patients.pdf.txt7bc67d6c9c792ed0815bbc9ecc84a225MD53THUMBNAILHTLV-I infection is not associated with a higher risk of death in Peruvian HIV-infected patients.pdf.jpgHTLV-I infection is not associated with a higher risk of death in Peruvian HIV-infected patients.pdf.jpgGenerated Thumbnailimage/jpeg7741https://repositorio.essalud.gob.pe/bitstream/20.500.12959/405/4/HTLV-I%20infection%20is%20not%20associated%20with%20a%20higher%20risk%20of%20death%20in%20Peruvian%20HIV-infected%20patients.pdf.jpg3e243ca26579fe468ff62e441d290dc8MD5420.500.12959/405oai:repositorio.essalud.gob.pe:20.500.12959/4052023-08-02 11:20:49.962Repositorio Seguro Social de Salud – ESSALUDbibliotecacentral@essalud.gob.peTk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo= |
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La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
