Latent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma in Lima, Peru.

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El Consejo Editorial es un equipo de expertos en el campo de la revista.
Detalles Bibliográficos
Autores: Huaman, Moises A., Henson, David, Rondan, Paola L., Ticona, Eduardo, Miranda, Gustavo, Kryscio, Richard J., Mugruza, Raquel, Aranda, Ernesto, Ticona, César, Abarca, Susan, Heredia, Paula, Aguirre, Andrés, Sterling, Timothy R., Garvy, Beth A., Fichtenbaum, Carl J.
Formato: artículo
Fecha de Publicación:2018
Institución:Seguro Social de Salud
Repositorio:ESSALUD-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.essalud.gob.pe:20.500.12959/544
Enlace del recurso:https://hdl.handle.net/20.500.12959/544
https://doi.org/10.1371/journal.pone.0202191
Nivel de acceso:acceso abierto
Materia:Inmunología
Interferón gamma
Tuberculosis
https://purl.org/pe-repo/ocde/ford#3.05.00
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dc.title.es_PE.fl_str_mv Latent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma in Lima, Peru.
title Latent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma in Lima, Peru.
spellingShingle Latent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma in Lima, Peru.
Huaman, Moises A.
Inmunología
Interferón gamma
Tuberculosis
https://purl.org/pe-repo/ocde/ford#3.05.00
title_short Latent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma in Lima, Peru.
title_full Latent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma in Lima, Peru.
title_fullStr Latent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma in Lima, Peru.
title_full_unstemmed Latent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma in Lima, Peru.
title_sort Latent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma in Lima, Peru.
author Huaman, Moises A.
author_facet Huaman, Moises A.
Henson, David
Rondan, Paola L.
Ticona, Eduardo
Miranda, Gustavo
Kryscio, Richard J.
Mugruza, Raquel
Aranda, Ernesto
Ticona, César
Abarca, Susan
Heredia, Paula
Aguirre, Andrés
Sterling, Timothy R.
Garvy, Beth A.
Fichtenbaum, Carl J.
author_role author
author2 Henson, David
Rondan, Paola L.
Ticona, Eduardo
Miranda, Gustavo
Kryscio, Richard J.
Mugruza, Raquel
Aranda, Ernesto
Ticona, César
Abarca, Susan
Heredia, Paula
Aguirre, Andrés
Sterling, Timothy R.
Garvy, Beth A.
Fichtenbaum, Carl J.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Huaman, Moises A.
Henson, David
Rondan, Paola L.
Ticona, Eduardo
Miranda, Gustavo
Kryscio, Richard J.
Mugruza, Raquel
Aranda, Ernesto
Ticona, César
Abarca, Susan
Heredia, Paula
Aguirre, Andrés
Sterling, Timothy R.
Garvy, Beth A.
Fichtenbaum, Carl J.
dc.subject.es_PE.fl_str_mv Inmunología
Interferón gamma
Tuberculosis
topic Inmunología
Interferón gamma
Tuberculosis
https://purl.org/pe-repo/ocde/ford#3.05.00
dc.subject.ocde.es_PE.fl_str_mv https://purl.org/pe-repo/ocde/ford#3.05.00
description El Consejo Editorial es un equipo de expertos en el campo de la revista.
publishDate 2018
dc.date.accessioned.none.fl_str_mv 2019-05-16T21:10:47Z
dc.date.available.none.fl_str_mv 2019-05-16T21:10:47Z
dc.date.issued.fl_str_mv 2018-09
dc.type.es_PE.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.citation.es_PE.fl_str_mv Plos One. 2018; 13(9).
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12959/544
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1371/journal.pone.0202191
identifier_str_mv Plos One. 2018; 13(9).
1932-6203
url https://hdl.handle.net/20.500.12959/544
https://doi.org/10.1371/journal.pone.0202191
dc.language.iso.es_PE.fl_str_mv eng
language eng
dc.relation.uri.none.fl_str_mv https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202191
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dc.publisher.es_PE.fl_str_mv Editorial Board
dc.publisher.country.es_PE.fl_str_mv PE
dc.source.es_PE.fl_str_mv Seguro Social de Salud (EsSalud)
Repositorio Institucional EsSalud
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spelling Huaman, Moises A.Henson, DavidRondan, Paola L.Ticona, EduardoMiranda, GustavoKryscio, Richard J.Mugruza, RaquelAranda, ErnestoTicona, CésarAbarca, SusanHeredia, PaulaAguirre, AndrésSterling, Timothy R.Garvy, Beth A.Fichtenbaum, Carl J.2019-05-16T21:10:47Z2019-05-16T21:10:47Z2018-09Plos One. 2018; 13(9).1932-6203https://hdl.handle.net/20.500.12959/544https://doi.org/10.1371/journal.pone.0202191El Consejo Editorial es un equipo de expertos en el campo de la revista.Se reportó previamente el incremento sin estimulación de niveles de interferón-gama en sangre, en personas con infección latente de tuberculosis (LTBI), en Estados Unidos, sugiriendo activación inmune mejorada en LTBI. Para investigar esto en un entorno endémico de tuberculosis, se evaluó los niveles de interferón gama in personas con y sin infección latente de tuberculosis en Perú. Se analizó la información de pacientes con y sin un reciente infarto agudo de miocardio tipo 1, seleccionados del Hospital Nacional Dos de Mayo y del Hospital Nacional Edgardo Rebagliati Martins in Lima, Perú, entre julio del 2015 y marzo de 2017. Se les hizo un examen de infección latente de tuberculosis usando el ensayo QuantiFERON® TB Gold In-tube (QFT), los pacientes con QFT positivo se definieron que tenían infección latente de tuberculosis. El interferón-gama no estimulado fue cuantificado vía prueba de ELISA (enzyme-linked immunosorbent assay). Se comparó los niveles de interferón-gama no estimulado entre los grupos con y sin infección latente de tuberculosis.Background: We previously reported increased unstimulated blood levels of interferon-gamma in persons with latent tuberculosis infection (LTBI) in the United States, suggesting enhanced immune activation in LTBI. To investigate this further in a TB-endemic setting, we assessed interferon-gamma levels in persons with and without LTBI in Peru. Methods: We analyzed data from patients with and without a recent type 1 (spontaneous) acute myocardial infarction (AMI) who were enrolled from two public hospital networks in Lima, Peru, and underwent LTBI testing using the QuantiFERON® TB Gold In-tube (QFT) assay. Participants with a positive QFT test were defined as having LTBI, whereas participants with a negative QFT test were defined as non-LTBI. Unstimulated interferon-gamma was quantified via enzyme-linked immunosorbent assay in the QFT nil-tube, which does not contain antigens. We compared unstimulated interferon-gamma levels between LTBI and non-LTBI groups using the Wilcoxon rank sum test. We used proportional odds modeling for multivariable analysis. Results: Data from 214 participants were included in this analysis. Of those, 120 (56%) had LTBI. There were no significant differences in age, sex and comorbidities between LTBI and nonLTBI participants, except for recent AMI that was more frequent in LTBI. LTBI participants had higher unstimulated interferon-gamma levels compared to non-LTBI participants (median, interquartile range; 14 pg/mL, 6.5–52.8 vs. 6.5 pg/mL, 4.5–15; P<0.01). LTBI remained associated with higher unstimulated interferon-gamma levels after controlling for age, sex, recent AMI, history of hypertension, diabetes mellitus, dyslipidemia, end stage renal disease, malignancy, obesity, and tobacco use (adjusted odds ratio, 2.93; 95% confidence interval, 1.8–4.9). In a sensitivity analysis that excluded participants with AMI, the association between unstimulated interferon-gamma and LTBI remained present (adjusted odds ratio; 3.93; 95% confidence interval, 1.9–8.2). Conclusions: LTBI was associated with higher unstimulated interferon-gamma levels. These data suggest ongoing immune activation in LTBI.application/pdfengEditorial BoardPEhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0202191info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/Seguro Social de Salud (EsSalud)Repositorio Institucional EsSaludreponame:ESSALUD-Institucionalinstname:Seguro Social de Saludinstacron:ESSALUDInmunologíaInterferón gammaTuberculosishttps://purl.org/pe-repo/ocde/ford#3.05.00Latent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma in Lima, Peru.info:eu-repo/semantics/articleORIGINALLatent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma.pdfLatent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma.pdfapplication/pdf1264257https://repositorio.essalud.gob.pe/bitstream/20.500.12959/544/1/Latent%20tuberculosis%20infection%20is%20associated%20with%20increased%20unstimulated%20levels%20of%20interferon-gamma.pdf041c0f97a408e4925c2ca5c5f8aa6ad6MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.essalud.gob.pe/bitstream/20.500.12959/544/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTLatent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma.pdf.txtLatent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma.pdf.txtExtracted texttext/plain30488https://repositorio.essalud.gob.pe/bitstream/20.500.12959/544/3/Latent%20tuberculosis%20infection%20is%20associated%20with%20increased%20unstimulated%20levels%20of%20interferon-gamma.pdf.txtdd1f5f7910fdc685cf0fe11cdfdcc1d2MD53THUMBNAILLatent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma.pdf.jpgLatent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma.pdf.jpgGenerated Thumbnailimage/jpeg6770https://repositorio.essalud.gob.pe/bitstream/20.500.12959/544/4/Latent%20tuberculosis%20infection%20is%20associated%20with%20increased%20unstimulated%20levels%20of%20interferon-gamma.pdf.jpgea3aa884c359c18b26a677d0c5c6a0f1MD5420.500.12959/544oai:repositorio.essalud.gob.pe:20.500.12959/5442023-07-31 10:07:53.339Repositorio Seguro Social de Salud – ESSALUDbibliotecacentral@essalud.gob.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Latent tuberculosis infection is associated with increased unstimulated levels of interferon-gamma in Lima, Peru.
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