Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections

• Autores: Abascal E., Herranz M., Acosta F., Agapito J., Cabibbe A.M., Monteserin J., Ruiz Serrano M.J., Gijón P., Fernández-González F., Lozano N., Chiner-Oms Á., Cáceres T., Pintado P.G., Acín E., Valencia E., Muñoz P., Comas I., Cirillo D.M., Ritacco V., Gotuzzo E., García de Viedma D.
• Formato: artículo
• Fecha de Publicación: 2020
• Institución: Consejo Nacional de Ciencia Tecnología e Innovación
• Repositorio: CONCYTEC-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorio.concytec.gob.pe:20.500.12390/2447
• Enlace del recurso: https://hdl.handle.net/20.500.12390/2447; https://doi.org/10.1038/s41598-020-59373-w
• Nivel de acceso: acceso abierto
• Materia: Humans; Antitubercular Agents; Bacterial Typing Techniques; Coinfection; Drug Resistance; http://purl.org/pe-repo/ocde/ford#3.03.08

It is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR–clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002–5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection. © 2020, The Author(s).