Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice
Descripción del Articulo
Peng Bo, Hu Qin, Xiaming Wen, Yang Keli, Jiang Zhen and Sandra Yucra are acknowledged for their help in this study. Special thanks to the joint financial support for this work from the National Nature Science Foundation of China, NSFC in 2004 (30472016/C03020701) and from Peruvian National Council o...
| Autores: | , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2007 |
| Institución: | Consejo Nacional de Ciencia Tecnología e Innovación |
| Repositorio: | CONCYTEC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorio.concytec.gob.pe:20.500.12390/734 |
| Enlace del recurso: | https://hdl.handle.net/20.500.12390/734 https://doi.org/10.1016/j.fct.2007.04.002 |
| Nivel de acceso: | acceso abierto |
| Materia: | treatment outcome acetylcholinesterase alcohol amine oxidase (flavin containing) Lepidium meyenii extract scopolamine animal experiment animal model animal tissue aqueous solution article avoidance behavior brain protection controlled study drug effect enzyme activity learning male maze test memory disorder mouse nonhuman treatment duration Acetylcholine Animals Avoidance Learning https://purl.org/pe-repo/ocde/ford#3.01.07 |
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4689 |
| dc.title.none.fl_str_mv |
Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice |
| title |
Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice |
| spellingShingle |
Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice Rubio J. treatment outcome acetylcholinesterase alcohol amine oxidase (flavin containing) Lepidium meyenii extract scopolamine animal experiment animal model animal tissue aqueous solution article avoidance behavior brain protection controlled study drug effect enzyme activity learning male maze test memory disorder mouse nonhuman treatment duration Acetylcholine Animals Avoidance Learning https://purl.org/pe-repo/ocde/ford#3.01.07 |
| title_short |
Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice |
| title_full |
Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice |
| title_fullStr |
Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice |
| title_full_unstemmed |
Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice |
| title_sort |
Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice |
| author |
Rubio J. |
| author_facet |
Rubio J. Dang H. Gong M. Liu X. Chen S.-l. Gonzales G.F. |
| author_role |
author |
| author2 |
Dang H. Gong M. Liu X. Chen S.-l. Gonzales G.F. |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Rubio J. Dang H. Gong M. Liu X. Chen S.-l. Gonzales G.F. |
| dc.subject.none.fl_str_mv |
treatment outcome |
| topic |
treatment outcome acetylcholinesterase alcohol amine oxidase (flavin containing) Lepidium meyenii extract scopolamine animal experiment animal model animal tissue aqueous solution article avoidance behavior brain protection controlled study drug effect enzyme activity learning male maze test memory disorder mouse nonhuman treatment duration Acetylcholine Animals Avoidance Learning https://purl.org/pe-repo/ocde/ford#3.01.07 |
| dc.subject.es_PE.fl_str_mv |
acetylcholinesterase alcohol amine oxidase (flavin containing) Lepidium meyenii extract scopolamine animal experiment animal model animal tissue aqueous solution article avoidance behavior brain protection controlled study drug effect enzyme activity learning male maze test memory disorder mouse nonhuman treatment duration Acetylcholine Animals Avoidance Learning |
| dc.subject.ocde.none.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#3.01.07 |
| description |
Peng Bo, Hu Qin, Xiaming Wen, Yang Keli, Jiang Zhen and Sandra Yucra are acknowledged for their help in this study. Special thanks to the joint financial support for this work from the National Nature Science Foundation of China, NSFC in 2004 (30472016/C03020701) and from Peruvian National Council of Sciences, Technology and Innovation (CONCYTEC) through the grant PROCOM 2005 and support for travel. Julio Rubio was on leave from the Universidad Peruana Cayetano Heredia, Peru (UPCH) through the Memorandum of Understanding between IMPLAD, CONCYTEC and UPCH. |
| publishDate |
2007 |
| dc.date.accessioned.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.available.none.fl_str_mv |
2024-05-30T23:13:38Z |
| dc.date.issued.fl_str_mv |
2007 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12390/734 |
| dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.fct.2007.04.002 |
| dc.identifier.scopus.none.fl_str_mv |
2-s2.0-34547734440 |
| url |
https://hdl.handle.net/20.500.12390/734 https://doi.org/10.1016/j.fct.2007.04.002 |
| identifier_str_mv |
2-s2.0-34547734440 |
| dc.language.iso.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.ispartof.none.fl_str_mv |
Food and Chemical Toxicology |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:CONCYTEC-Institucional instname:Consejo Nacional de Ciencia Tecnología e Innovación instacron:CONCYTEC |
| instname_str |
Consejo Nacional de Ciencia Tecnología e Innovación |
| instacron_str |
CONCYTEC |
| institution |
CONCYTEC |
| reponame_str |
CONCYTEC-Institucional |
| collection |
CONCYTEC-Institucional |
| repository.name.fl_str_mv |
Repositorio Institucional CONCYTEC |
| repository.mail.fl_str_mv |
repositorio@concytec.gob.pe |
| _version_ |
1839175591758135296 |
| spelling |
Publicationrp01560500rp01870600rp01869600rp01868600rp01871600rp00575500Rubio J.Dang H.Gong M.Liu X.Chen S.-l.Gonzales G.F.2024-05-30T23:13:38Z2024-05-30T23:13:38Z2007https://hdl.handle.net/20.500.12390/734https://doi.org/10.1016/j.fct.2007.04.0022-s2.0-34547734440Peng Bo, Hu Qin, Xiaming Wen, Yang Keli, Jiang Zhen and Sandra Yucra are acknowledged for their help in this study. Special thanks to the joint financial support for this work from the National Nature Science Foundation of China, NSFC in 2004 (30472016/C03020701) and from Peruvian National Council of Sciences, Technology and Innovation (CONCYTEC) through the grant PROCOM 2005 and support for travel. Julio Rubio was on leave from the Universidad Peruana Cayetano Heredia, Peru (UPCH) through the Memorandum of Understanding between IMPLAD, CONCYTEC and UPCH.Lepidium meyenii Walp. (Brassicaceae), known as Maca, is a Peruvian hypocotyl growing exclusively between 4000 and 4500 m altitude in the central Peruvian Andes, particularly in Junin plateau. Previously, Black variety of Maca showed to be more beneficial than other varieties of Maca on learning and memory in ovariectomized mice on the water finding test. The present study aimed to test two different doses of aqueous (0.50 and 2.00 g/kg) and hydroalcoholic (0.25 and 1.00 g/kg) extracts of Black Maca administered for 35 days on memory impairment induced by scopolamine (1 mg/kg body weight i.p.) in male mice. Memory and learning were evaluated using the water Morris maze and the step-down avoidance test. Brain acetylcholinesterase (AChE) and monoamine oxidase (MAO) activities in brain were also determined. Both extracts of Black Maca significantly ameliorated the scopolamine-induced memory impairment as measured in both the water Morris maze and the step-down avoidance tests. Black Maca extracts inhibited AChE activity, whereas MAO activity was not affected. These results indicate that Black Maca improves scopolamine-induced memory deficits.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengElsevierFood and Chemical Toxicologyinfo:eu-repo/semantics/openAccesstreatment outcomeacetylcholinesterase-1alcohol-1amine oxidase (flavin containing)-1Lepidium meyenii extract-1scopolamine-1animal experiment-1animal model-1animal tissue-1aqueous solution-1article-1avoidance behavior-1brain protection-1controlled study-1drug effect-1enzyme activity-1learning-1male-1maze test-1memory disorder-1mouse-1nonhuman-1treatment duration-1Acetylcholine-1Animals-1Avoidance Learning-1https://purl.org/pe-repo/ocde/ford#3.01.07-1Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in miceinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTEC20.500.12390/734oai:repositorio.concytec.gob.pe:20.500.12390/7342024-05-30 15:58:51.671http://purl.org/coar/access_right/c_14cbinfo:eu-repo/semantics/closedAccessmetadata only accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="6ef99d2b-d49a-4e65-a978-5f074ec29321"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice</Title> <PublishedIn> <Publication> <Title>Food and Chemical Toxicology</Title> </Publication> </PublishedIn> <PublicationDate>2007</PublicationDate> <DOI>https://doi.org/10.1016/j.fct.2007.04.002</DOI> <SCP-Number>2-s2.0-34547734440</SCP-Number> <Authors> <Author> <DisplayName>Rubio J.</DisplayName> <Person id="rp01560" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Dang H.</DisplayName> <Person id="rp01870" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Gong M.</DisplayName> <Person id="rp01869" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Liu X.</DisplayName> <Person id="rp01868" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Chen S.-l.</DisplayName> <Person id="rp01871" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Gonzales G.F.</DisplayName> <Person id="rp00575" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Elsevier</DisplayName> <OrgUnit /> </Publisher> </Publishers> <Keyword>treatment outcome</Keyword> <Keyword>acetylcholinesterase</Keyword> <Keyword>alcohol</Keyword> <Keyword>amine oxidase (flavin containing)</Keyword> <Keyword>Lepidium meyenii extract</Keyword> <Keyword>scopolamine</Keyword> <Keyword>animal experiment</Keyword> <Keyword>animal model</Keyword> <Keyword>animal tissue</Keyword> <Keyword>aqueous solution</Keyword> <Keyword>article</Keyword> <Keyword>avoidance behavior</Keyword> <Keyword>brain protection</Keyword> <Keyword>controlled study</Keyword> <Keyword>drug effect</Keyword> <Keyword>enzyme activity</Keyword> <Keyword>learning</Keyword> <Keyword>male</Keyword> <Keyword>maze test</Keyword> <Keyword>memory disorder</Keyword> <Keyword>mouse</Keyword> <Keyword>nonhuman</Keyword> <Keyword>treatment duration</Keyword> <Keyword>Acetylcholine</Keyword> <Keyword>Animals</Keyword> <Keyword>Avoidance Learning</Keyword> <Abstract>Lepidium meyenii Walp. (Brassicaceae), known as Maca, is a Peruvian hypocotyl growing exclusively between 4000 and 4500 m altitude in the central Peruvian Andes, particularly in Junin plateau. Previously, Black variety of Maca showed to be more beneficial than other varieties of Maca on learning and memory in ovariectomized mice on the water finding test. The present study aimed to test two different doses of aqueous (0.50 and 2.00 g/kg) and hydroalcoholic (0.25 and 1.00 g/kg) extracts of Black Maca administered for 35 days on memory impairment induced by scopolamine (1 mg/kg body weight i.p.) in male mice. Memory and learning were evaluated using the water Morris maze and the step-down avoidance test. Brain acetylcholinesterase (AChE) and monoamine oxidase (MAO) activities in brain were also determined. Both extracts of Black Maca significantly ameliorated the scopolamine-induced memory impairment as measured in both the water Morris maze and the step-down avoidance tests. Black Maca extracts inhibited AChE activity, whereas MAO activity was not affected. These results indicate that Black Maca improves scopolamine-induced memory deficits.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1 |
| score |
13.4481325 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
