Safety Profile of Caesalpinia spinosa Aqueous Extract Tested in Oreochromis niloticus Toward Its Application in Dermocosmetics

Descripción del Articulo

The authors thank CONCYTEC-FONDECYT, process E041-01 (Contract number 123-2018-FONDECYT-BM-IADT/AV), and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Process 305250/2019-1).
Detalles Bibliográficos
Autores: Salirrosas Fernández, Remigio David, Reátegui Pinedo, Nataly Yahayra, Crespo, Jan Pier, Sánchez Tuesta, Linda Cristina, Cabrera, Angelita, Miliani Martinez, Renata, Ayala-Jara, Carmen, Rolim Baby, André, Prieto Lara, Zulita Adriana
Formato: artículo
Fecha de Publicación:2021
Institución:Consejo Nacional de Ciencia Tecnología e Innovación
Repositorio:CONCYTEC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.concytec.gob.pe:20.500.12390/3162
Enlace del recurso:https://hdl.handle.net/20.500.12390/3162
https://doi.org/10.3389/frsus.2021.696289
Nivel de acceso:acceso abierto
Materia:safety
Caesalpinia spinosa
Oreochromis niloticus
herbal extract
natural cosmetic
https://purl.org/pe-repo/ocde/ford#3.02.27
id CONC_7eb308f73f967f39da39eb53e68258d7
oai_identifier_str oai:repositorio.concytec.gob.pe:20.500.12390/3162
network_acronym_str CONC
network_name_str CONCYTEC-Institucional
repository_id_str 4689
dc.title.none.fl_str_mv Safety Profile of Caesalpinia spinosa Aqueous Extract Tested in Oreochromis niloticus Toward Its Application in Dermocosmetics
title Safety Profile of Caesalpinia spinosa Aqueous Extract Tested in Oreochromis niloticus Toward Its Application in Dermocosmetics
spellingShingle Safety Profile of Caesalpinia spinosa Aqueous Extract Tested in Oreochromis niloticus Toward Its Application in Dermocosmetics
Salirrosas Fernández, Remigio David
safety
Caesalpinia spinosa
Oreochromis niloticus
herbal extract
natural cosmetic
https://purl.org/pe-repo/ocde/ford#3.02.27
title_short Safety Profile of Caesalpinia spinosa Aqueous Extract Tested in Oreochromis niloticus Toward Its Application in Dermocosmetics
title_full Safety Profile of Caesalpinia spinosa Aqueous Extract Tested in Oreochromis niloticus Toward Its Application in Dermocosmetics
title_fullStr Safety Profile of Caesalpinia spinosa Aqueous Extract Tested in Oreochromis niloticus Toward Its Application in Dermocosmetics
title_full_unstemmed Safety Profile of Caesalpinia spinosa Aqueous Extract Tested in Oreochromis niloticus Toward Its Application in Dermocosmetics
title_sort Safety Profile of Caesalpinia spinosa Aqueous Extract Tested in Oreochromis niloticus Toward Its Application in Dermocosmetics
author Salirrosas Fernández, Remigio David
author_facet Salirrosas Fernández, Remigio David
Reátegui Pinedo, Nataly Yahayra
Crespo, Jan Pier
Sánchez Tuesta, Linda Cristina
Cabrera, Angelita
Miliani Martinez, Renata
Ayala-Jara, Carmen
Rolim Baby, André
Prieto Lara, Zulita Adriana
author_role author
author2 Reátegui Pinedo, Nataly Yahayra
Crespo, Jan Pier
Sánchez Tuesta, Linda Cristina
Cabrera, Angelita
Miliani Martinez, Renata
Ayala-Jara, Carmen
Rolim Baby, André
Prieto Lara, Zulita Adriana
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Salirrosas Fernández, Remigio David
Reátegui Pinedo, Nataly Yahayra
Crespo, Jan Pier
Sánchez Tuesta, Linda Cristina
Cabrera, Angelita
Miliani Martinez, Renata
Ayala-Jara, Carmen
Rolim Baby, André
Prieto Lara, Zulita Adriana
dc.subject.none.fl_str_mv safety
topic safety
Caesalpinia spinosa
Oreochromis niloticus
herbal extract
natural cosmetic
https://purl.org/pe-repo/ocde/ford#3.02.27
dc.subject.es_PE.fl_str_mv Caesalpinia spinosa
Oreochromis niloticus
herbal extract
natural cosmetic
dc.subject.ocde.none.fl_str_mv https://purl.org/pe-repo/ocde/ford#3.02.27
description The authors thank CONCYTEC-FONDECYT, process E041-01 (Contract number 123-2018-FONDECYT-BM-IADT/AV), and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Process 305250/2019-1).
publishDate 2021
dc.date.accessioned.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.available.none.fl_str_mv 2024-05-30T23:13:38Z
dc.date.issued.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12390/3162
dc.identifier.doi.none.fl_str_mv https://doi.org/10.3389/frsus.2021.696289
url https://hdl.handle.net/20.500.12390/3162
https://doi.org/10.3389/frsus.2021.696289
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Frontiers MediaFrontiers in Sustainability
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.none.fl_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONCYTEC-Institucional
instname:Consejo Nacional de Ciencia Tecnología e Innovación
instacron:CONCYTEC
instname_str Consejo Nacional de Ciencia Tecnología e Innovación
instacron_str CONCYTEC
institution CONCYTEC
reponame_str CONCYTEC-Institucional
collection CONCYTEC-Institucional
bitstream.url.fl_str_mv https://repositorio.concytec.gob.pe/bitstreams/9e826a16-2dee-5aa3-a4ec-78e6c028f1d6/download
https://repositorio.concytec.gob.pe/bitstreams/4b3682a9-f8a0-83b1-e951-a40218e12bcd/download
https://repositorio.concytec.gob.pe/bitstreams/a4beaae6-1f92-4bcf-a324-e6a9172f6f90/download
bitstream.checksum.fl_str_mv e2b23a253d7c1df292668c82c6fb550b
00e6a237c51aa240d1eb56f55b8633b2
167123b5c5b23e5205f6e60afc59cabb
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
repository.name.fl_str_mv Repositorio Institucional CONCYTEC
repository.mail.fl_str_mv repositorio@concytec.gob.pe
_version_ 1839175805757816832
spelling Publicationrp08951600rp08954600rp08960600rp08953600rp08957600rp08955600rp08717600rp08719600rp08720600Salirrosas Fernández, Remigio DavidReátegui Pinedo, Nataly YahayraCrespo, Jan PierSánchez Tuesta, Linda CristinaCabrera, AngelitaMiliani Martinez, RenataAyala-Jara, CarmenRolim Baby, AndréPrieto Lara, Zulita Adriana2024-05-30T23:13:38Z2024-05-30T23:13:38Z2021https://hdl.handle.net/20.500.12390/3162https://doi.org/10.3389/frsus.2021.696289The authors thank CONCYTEC-FONDECYT, process E041-01 (Contract number 123-2018-FONDECYT-BM-IADT/AV), and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Process 305250/2019-1).Herbal extracts have been widely used in dermocosmetics as a source of biomolecules and also as a natural claim. Fruits from Caesalpinia spinosa show great potential for their polyphenolic content, preservative, and film-forming features, as previously reported in specialized literature; however, the toxicity requires investigation. We explored Oreochromis niloticus (tilapia) in larval, alevins, and juvenile stages to evaluate the ex vivo and in vivo genotoxicity and in vivo acute and chronic toxicity of C. spinosa aqueous extract in different concentrations. Cytotoxicity, animal behavior, morphological deformities, and DNA damage were evaluated. Our results showed genotoxic effect in ex vivo tests, but no DNA damage in in vivo erythrocytes. We suggest a mechanism of cell permeability involved in the toxicity of C. spinosa aqueous extract. Internal validation showed the feasibility of O. niloticus applied for toxicity evaluation. Further studies could contribute for better understanding the uses and safety of C. spinosa in cosmetics and topical pharmaceutical products.Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica - ConcytecengFrontiers MediaFrontiers MediaFrontiers in Sustainabilityinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/4.0/safetyCaesalpinia spinosa-1Oreochromis niloticus-1herbal extract-1natural cosmetic-1https://purl.org/pe-repo/ocde/ford#3.02.27-1Safety Profile of Caesalpinia spinosa Aqueous Extract Tested in Oreochromis niloticus Toward Its Application in Dermocosmeticsinfo:eu-repo/semantics/articlereponame:CONCYTEC-Institucionalinstname:Consejo Nacional de Ciencia Tecnología e Innovacióninstacron:CONCYTECORIGINAL2021_Safety profile of Caesalpinia spinosa aqueous extract....pdf2021_Safety profile of Caesalpinia spinosa aqueous extract....pdfapplication/pdf1537651https://repositorio.concytec.gob.pe/bitstreams/9e826a16-2dee-5aa3-a4ec-78e6c028f1d6/downloade2b23a253d7c1df292668c82c6fb550bMD51THUMBNAIL2021_Safety profile of Caesalpinia spinosa aqueous extract....pdf.jpg2021_Safety profile of Caesalpinia spinosa aqueous extract....pdf.jpgIM Thumbnailimage/jpeg12812https://repositorio.concytec.gob.pe/bitstreams/4b3682a9-f8a0-83b1-e951-a40218e12bcd/download00e6a237c51aa240d1eb56f55b8633b2MD52TEXT2021_Safety profile of Caesalpinia spinosa aqueous extract....pdf.txt2021_Safety profile of Caesalpinia spinosa aqueous extract....pdf.txtExtracted texttext/plain47016https://repositorio.concytec.gob.pe/bitstreams/a4beaae6-1f92-4bcf-a324-e6a9172f6f90/download167123b5c5b23e5205f6e60afc59cabbMD5320.500.12390/3162oai:repositorio.concytec.gob.pe:20.500.12390/31622024-06-19 21:06:23.676https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessopen accesshttps://repositorio.concytec.gob.peRepositorio Institucional CONCYTECrepositorio@concytec.gob.pe#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#<Publication xmlns="https://www.openaire.eu/cerif-profile/1.1/" id="eb771340-4b18-4889-ace8-c91e94299c8a"> <Type xmlns="https://www.openaire.eu/cerif-profile/vocab/COAR_Publication_Types">http://purl.org/coar/resource_type/c_1843</Type> <Language>eng</Language> <Title>Safety Profile of Caesalpinia spinosa Aqueous Extract Tested in Oreochromis niloticus Toward Its Application in Dermocosmetics</Title> <PublishedIn> <Publication> <Title>Frontiers MediaFrontiers in Sustainability</Title> </Publication> </PublishedIn> <PublicationDate>2021</PublicationDate> <DOI>https://doi.org/10.3389/frsus.2021.696289</DOI> <Authors> <Author> <DisplayName>Salirrosas Fernández, Remigio David</DisplayName> <Person id="rp08951" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Reátegui Pinedo, Nataly Yahayra</DisplayName> <Person id="rp08954" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Crespo, Jan Pier</DisplayName> <Person id="rp08960" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Sánchez Tuesta, Linda Cristina</DisplayName> <Person id="rp08953" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Cabrera, Angelita</DisplayName> <Person id="rp08957" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Miliani Martinez, Renata</DisplayName> <Person id="rp08955" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Ayala-Jara, Carmen</DisplayName> <Person id="rp08717" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Rolim Baby, André</DisplayName> <Person id="rp08719" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> <Author> <DisplayName>Prieto Lara, Zulita Adriana</DisplayName> <Person id="rp08720" /> <Affiliation> <OrgUnit> </OrgUnit> </Affiliation> </Author> </Authors> <Editors> </Editors> <Publishers> <Publisher> <DisplayName>Frontiers Media</DisplayName> <OrgUnit /> </Publisher> </Publishers> <License>https://creativecommons.org/licenses/by-nc-nd/4.0/</License> <Keyword>safety</Keyword> <Keyword>Caesalpinia spinosa</Keyword> <Keyword>Oreochromis niloticus</Keyword> <Keyword>herbal extract</Keyword> <Keyword>natural cosmetic</Keyword> <Abstract>Herbal extracts have been widely used in dermocosmetics as a source of biomolecules and also as a natural claim. Fruits from Caesalpinia spinosa show great potential for their polyphenolic content, preservative, and film-forming features, as previously reported in specialized literature; however, the toxicity requires investigation. We explored Oreochromis niloticus (tilapia) in larval, alevins, and juvenile stages to evaluate the ex vivo and in vivo genotoxicity and in vivo acute and chronic toxicity of C. spinosa aqueous extract in different concentrations. Cytotoxicity, animal behavior, morphological deformities, and DNA damage were evaluated. Our results showed genotoxic effect in ex vivo tests, but no DNA damage in in vivo erythrocytes. We suggest a mechanism of cell permeability involved in the toxicity of C. spinosa aqueous extract. Internal validation showed the feasibility of O. niloticus applied for toxicity evaluation. Further studies could contribute for better understanding the uses and safety of C. spinosa in cosmetics and topical pharmaceutical products.</Abstract> <Access xmlns="http://purl.org/coar/access_right" > </Access> </Publication> -1
score 13.4481325
Safety Profile of Caesalpinia spinosa Aqueous Extract Tested in Oreochromis niloticus Toward Its Application in Dermocosmetics
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).

Ejemplares Similares