Gastroesophageal reflux disease as a factor associated with bronchial asthma in the pediatric population

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Objective: To determine the relationship between gastroesophageal reflux disease and bronchial asthma in the pediatric population of the National Children's Hospital Breña headquarters between the years 2017-2018. Methods: An analytical observational study of cases and controls was not matched,...

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Autores: Ricra, Rafael, Roque, Juan Carlos, Alburqueque-Melgarejo, Joseph, Ricra, Pedro, Saldaña, Claudia
Formato: artículo
Fecha de Publicación:2020
Institución:Universidad Ricardo Palma
Repositorio:Revista URP - Revista de la Facultad de Medicina Humana
Lenguaje:español
inglés
OAI Identifier:oai:oai.revistas.urp.edu.pe:article/2918
Enlace del recurso:http://revistas.urp.edu.pe/index.php/RFMH/article/view/2918
Nivel de acceso:acceso abierto
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spelling Gastroesophageal reflux disease as a factor associated with bronchial asthma in the pediatric populationEnfermedad por reflujo gastroesofágico como factor asociado a asma bronquial en población pediátricaRicra, RafaelRoque, Juan CarlosAlburqueque-Melgarejo, JosephRicra, PedroSaldaña, ClaudiaObjective: To determine the relationship between gastroesophageal reflux disease and bronchial asthma in the pediatric population of the National Children's Hospital Breña headquarters between the years 2017-2018. Methods: An analytical observational study of cases and controls was not matched, with a ratio of 1 case to 2 controls, with a total of 45 cases and 90 controls, a simple random probability sampling was performed, with a retrospective collection for the variables bronchial asthma, GERD, GERDinduced esophagitis, prematurity, interrupted breastfeeding, sex and age. A bivariate and multiple logistic regression model was performed to obtain the Odds Ratio for the strength of association. Results: A statistically significant difference was found for GERD (p = 0.002), being 33.33% and 11.11% for cases and controls, as well as for interrupted lactation (p = 0.013); by multiple logistic regression analysis the variables GERD (OR 4.27, p = 0.003, CI 1.64-10.92) and interrupted breastfeeding (OR 2.74, P = 0.011, CI 1.26-5.97 ) presented a relationship for bronchial asthma. Conclusion: A relationship was found between GERD and bronchial asthma which can be extrapolated to the pediatric population of the city of Lima, this is the first article published in this regard at the national level, prospective studies are recommended to determine causality.Objetivo: Determinar la relación entre enfermedad por reflujo gastroesofágico y asma bronquial en la población pediátrica del hospital Nacional del niño sede Breña entre los años 2017-2018. Métodos: Se realizó un estudio observacional analítico tipo casos y controles no emparejado de razón 1 caso para 2 controles, con un total de 45 casos y 90 controles, se realizó un muestreo probabilístico aleatorio simple, con una recolección retrospectiva para las variables asma bronquial, ERGE, esofagitis inducida por ERGE, prematuridad, lactancia materna interrumpida, sexo y edad. Se realizó un modelo de regresión logística bivariado y múltiple para la obtención del Odds Ratio para la fuerza de asociación. Resultados: Se encontró una diferencia estadísticamente significativa para ERGE (p=0,002), siendo 33,33% y 11,11% para los casos y controles, así como para lactancia interrumpida (p=0,013); por análisis de regresión logística múltiple las variables ERGE (OR 4,27, p=0,003, IC 1,64-10,92) y lactancia materna interrumpida (OR 2,74, P=0,011, IC 1,26-5,97) presentaron relación para asma bronquial. Conclusión: Se encontró una relación entre ERGE y asma bronquial la cual puede ser extrapolada a la población pediátrica de la ciudad de Lima, este es el primer artículo publicado al respecto a nivel nacional, se recomiendan estudios prospectivos para determinar causalidad.Universidad Ricardo Palma2020-03-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlapplication/pdftext/htmlhttp://revistas.urp.edu.pe/index.php/RFMH/article/view/291810.25176/RFMH.v20i2.2918Revista de la Facultad de Medicina Humana; Vol 20 No 2 (2020): Revista de la Facultad de Medicina Humana; 1Revista de la Facultad de Medicina Humana; Vol. 20 Núm. 2 (2020): Revista de la Facultad de Medicina Humana; 12308-05311814-5469reponame:Revista URP - Revista de la Facultad de Medicina Humanainstname:Universidad Ricardo Palmainstacron:URPspaenghttp://revistas.urp.edu.pe/index.php/RFMH/article/view/2918/3070http://revistas.urp.edu.pe/index.php/RFMH/article/view/2918/3071http://revistas.urp.edu.pe/index.php/RFMH/article/view/2918/3072http://revistas.urp.edu.pe/index.php/RFMH/article/view/2918/3073info:eu-repo/semantics/openAccess2021-06-02T16:10:24Zmail@mail.com -
dc.title.none.fl_str_mv Gastroesophageal reflux disease as a factor associated with bronchial asthma in the pediatric population
Enfermedad por reflujo gastroesofágico como factor asociado a asma bronquial en población pediátrica
title Gastroesophageal reflux disease as a factor associated with bronchial asthma in the pediatric population
spellingShingle Gastroesophageal reflux disease as a factor associated with bronchial asthma in the pediatric population
Ricra, Rafael
title_short Gastroesophageal reflux disease as a factor associated with bronchial asthma in the pediatric population
title_full Gastroesophageal reflux disease as a factor associated with bronchial asthma in the pediatric population
title_fullStr Gastroesophageal reflux disease as a factor associated with bronchial asthma in the pediatric population
title_full_unstemmed Gastroesophageal reflux disease as a factor associated with bronchial asthma in the pediatric population
title_sort Gastroesophageal reflux disease as a factor associated with bronchial asthma in the pediatric population
dc.creator.none.fl_str_mv Ricra, Rafael
Roque, Juan Carlos
Alburqueque-Melgarejo, Joseph
Ricra, Pedro
Saldaña, Claudia
author Ricra, Rafael
author_facet Ricra, Rafael
Roque, Juan Carlos
Alburqueque-Melgarejo, Joseph
Ricra, Pedro
Saldaña, Claudia
author_role author
author2 Roque, Juan Carlos
Alburqueque-Melgarejo, Joseph
Ricra, Pedro
Saldaña, Claudia
author2_role author
author
author
author
dc.description.none.fl_txt_mv Objective: To determine the relationship between gastroesophageal reflux disease and bronchial asthma in the pediatric population of the National Children's Hospital Breña headquarters between the years 2017-2018. Methods: An analytical observational study of cases and controls was not matched, with a ratio of 1 case to 2 controls, with a total of 45 cases and 90 controls, a simple random probability sampling was performed, with a retrospective collection for the variables bronchial asthma, GERD, GERDinduced esophagitis, prematurity, interrupted breastfeeding, sex and age. A bivariate and multiple logistic regression model was performed to obtain the Odds Ratio for the strength of association. Results: A statistically significant difference was found for GERD (p = 0.002), being 33.33% and 11.11% for cases and controls, as well as for interrupted lactation (p = 0.013); by multiple logistic regression analysis the variables GERD (OR 4.27, p = 0.003, CI 1.64-10.92) and interrupted breastfeeding (OR 2.74, P = 0.011, CI 1.26-5.97 ) presented a relationship for bronchial asthma. Conclusion: A relationship was found between GERD and bronchial asthma which can be extrapolated to the pediatric population of the city of Lima, this is the first article published in this regard at the national level, prospective studies are recommended to determine causality.
Objetivo: Determinar la relación entre enfermedad por reflujo gastroesofágico y asma bronquial en la población pediátrica del hospital Nacional del niño sede Breña entre los años 2017-2018. Métodos: Se realizó un estudio observacional analítico tipo casos y controles no emparejado de razón 1 caso para 2 controles, con un total de 45 casos y 90 controles, se realizó un muestreo probabilístico aleatorio simple, con una recolección retrospectiva para las variables asma bronquial, ERGE, esofagitis inducida por ERGE, prematuridad, lactancia materna interrumpida, sexo y edad. Se realizó un modelo de regresión logística bivariado y múltiple para la obtención del Odds Ratio para la fuerza de asociación. Resultados: Se encontró una diferencia estadísticamente significativa para ERGE (p=0,002), siendo 33,33% y 11,11% para los casos y controles, así como para lactancia interrumpida (p=0,013); por análisis de regresión logística múltiple las variables ERGE (OR 4,27, p=0,003, IC 1,64-10,92) y lactancia materna interrumpida (OR 2,74, P=0,011, IC 1,26-5,97) presentaron relación para asma bronquial. Conclusión: Se encontró una relación entre ERGE y asma bronquial la cual puede ser extrapolada a la población pediátrica de la ciudad de Lima, este es el primer artículo publicado al respecto a nivel nacional, se recomiendan estudios prospectivos para determinar causalidad.
description Objective: To determine the relationship between gastroesophageal reflux disease and bronchial asthma in the pediatric population of the National Children's Hospital Breña headquarters between the years 2017-2018. Methods: An analytical observational study of cases and controls was not matched, with a ratio of 1 case to 2 controls, with a total of 45 cases and 90 controls, a simple random probability sampling was performed, with a retrospective collection for the variables bronchial asthma, GERD, GERDinduced esophagitis, prematurity, interrupted breastfeeding, sex and age. A bivariate and multiple logistic regression model was performed to obtain the Odds Ratio for the strength of association. Results: A statistically significant difference was found for GERD (p = 0.002), being 33.33% and 11.11% for cases and controls, as well as for interrupted lactation (p = 0.013); by multiple logistic regression analysis the variables GERD (OR 4.27, p = 0.003, CI 1.64-10.92) and interrupted breastfeeding (OR 2.74, P = 0.011, CI 1.26-5.97 ) presented a relationship for bronchial asthma. Conclusion: A relationship was found between GERD and bronchial asthma which can be extrapolated to the pediatric population of the city of Lima, this is the first article published in this regard at the national level, prospective studies are recommended to determine causality.
publishDate 2020
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Revista de la Facultad de Medicina Humana; Vol. 20 Núm. 2 (2020): Revista de la Facultad de Medicina Humana; 1
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