We present the case of a 25-year-old woman with a three-month history of cough, fever, dyspnea, pleuritic pain, and a cavitating lesion on chest tomography. She received antituberculous treatment in another health institution without a favorable response. A thoracoscopic biopsy revealed the presence of Reed Sternberg cells consistent with the nodular sclerosis subtype of Hodgkin’s lymphoma. The patient met the criteria for primary pulmonary Hodgkin’s lymphoma, an extremely infrequent and rarely reported entity. A brief review of the literature is carried out.

Presentamos el caso de una mujer de 53 años con antecedentes de artritis reumatoide que, tras recuperarse de un cuadro de COVID-19grave, desarrolló hemorragia digestiva como manifestación de hipertensión portal e insuficiencia hepática progresiva. Basados en la serología y ecografía, se diagnosticó un síndrome overlap de hepatitis autoinmune y colangitis biliar primaria asociado a trombosis de vena porta. La respuesta a la corticoterapia y anticoagulación fue favorable. El compromiso hepático, inducido por el virus, está descrito en la COVID-19. Sin embargo, pueden desarrollarse enfermedades autoinmunes y fenómenos tromboembólicos, teniendo el hígado como órgano diana.

We present the case of a 53-year-old woman with a history of rheumatoid arthritis who, after recovering from a severe COVID-19, developed gastrointestinal bleeding as a manifestation of portal hypertension and progressive liver failure. Based on serology and ultrasound, an overlap syndrome of autoimmune hepatitis and primary biliary cholangitis associated with portal vein thrombosis were diagnosed. The response to steroids and anticoagulation was favorable. Hepatic involvement, induced by the virus, has been described in COVID-19. However, autoimmune diseases and thromboembolic phenomena can develop, having the liver as a target organ.