Define la expresión de Ligando de la proteína de muerte programada 1 (PD-L1) y la presencia del RNA del Virus Epstein-Barr (VEB) en células neoplásicas célula neoplásica del LHC (HRS), de la proteína PD-1 en los linfocitos del Microambiente tumoral (MAT) y buscar la relación de estos hallazgos con la SG en pacientes con Linfoma de Hodgkin (LH) ingresados al Instituto Nacional de Enfermedades Neoplásicas (INEN) en el periodo 2015 - 2018. La determinación de la proteína de muerte programada 1 (PD-1) en los linfocitos presentes en el microambiente tumoral (MAT) y de su ligando (PDL1) en las células neoplásicas han demostrado tener impacto en el pronóstico de diversas neoplasias. Asimismo, la presencia de un alto porcentaje de PDL1 presente en células neoplásicas se ha asociado a una buena respuesta a la inmunoterapia con moléculas anti-PD-1 o anti PD-L1. Actualmente en el P...

Objective: Various studies on Hodgkin’s lymphoma (HL) have determined programmed death-ligand 1 (PD-L1) expression in Hodgkin and Reed-Sternberg (HRS) cells, with variable results. This protein has gained relevance for its role in theimmune response in malignant neoplasms. This work aimed to determine PD-L1 immunohistochemical expression in HRS cells and its relationship with age, sex, clinical stage and overall survival (OS) in a cohort of Peruvian patients. Materials and methods: Twenty-five (25) biopsies from patients diagnosed with HL were assessed, which allowed determining PD-L1 immunohistochemical expression in HRS cells in relation to OS and clinical data of the patients. Results: All cases showed PD-L1 expression in more than 1 % of tumor cells. There was no statistically significant difference in OS when two groups were compared in terms of PD-L1 expression with a cut-off poi...

Medulloblastomas are the most common malignant brain neoplasms in children. Immunohistochemical(IHC) markers can determine a molecular classification, using the markers GAB1, YAP1, β-catenin, P53, and Ki67. The classification of these neoplasms into molecular groups has proven to be clinically and therapeutically significant. The clinical outcomes of medulloblastoma include death, adverseeffects or conditions, and tumor recurrence. The objective of this research was to determine the individual association between the IHC markers used for molecular group classification and the clinical outcome in patients with medulloblastoma treated at the Instituto Nacional de Salud del Niño (INSN - National Institute of Child Health) during the period 2013–2022. The population consisted of 58 patients. The individual IHC expression of GAB1, YAP1, β-catenin, p53, and Ki67 in paraffin-embedded biops...