Objective: To determine the relationship and connecting factors between pre-existing diseases, medication intake and peritraumatic distress in physicians in face-to-face activity in the city of Lima, Peru during the COVID-19 pandemic. Method: The study included physicians working in the first line of care of patients with COVID-19, as well as physicians working in other areas. The instruments used were the COVID-19 related Peritraumatic Distress Index (CPDI), Patient Health Questionnaire-9 (PHQ-9), and Generalized Anxiety Disorder Scale-7 (GAD-7). A general linear model was performed taking the CPDI values as the dependent variable to assess distress-related factors. Results: 288 physicians were included, 54.50% of whom worked in the front line. The CPDI value showed a direct relationship with GAD-7 and PHQ-9, as well as with medical illness. A statistically significant direct relationsh...