Chemotherapy of tumors of trophoblast has been successful in several ways. From a practical standpoint, it has allowed for the first time healing a malignant tumor with the use of chemical agents, changing the poor prognosis that had chorioepithelioma less than a decade. From the point of view of tumor biology, it has provided an opportunity to study the tumor guest relations on a "grafted" neoplasia in humans. From the biochemical point of view, it has proven the importance of certain metabolites in a selective way some cancers. The epidemiology and natural history of corioncarcinoma also been studied with renewed interest after advenimento of this therapy.

Between 1962 and 1980, the Departments of Gynecology and Medical Oncology INEN have handled 170 cases of trophoblastic disease. All patients had clinical and / or radiographic evidence and hormonal disease activity; histopathologic evidence was obtained when the disease was accessible to biopsy. Half of the patients are in the third decade of life, and a quarter in the fourth decade; 8 percent were under 20 years old. Only 27 percent of cases were under three months of sick time; in 21 percent of cases the disease duration was more than one year. 64.7% of cases had a history of mole, and 20 percent of abortion; in 10% of cases of history was normal delivery. Only 110 patients (64.75%) showed evidence of pelvic disease admission; 35% of 110 cases found evidence of disease in the pelvis. 55% of cases presented lung metastases, and 20% vulvovaginal metastasis; intestinal metastasis, liver o...

The effects of pregnancy in 8 cases of leukemia and lymphoma 14 cases with this complication are discussed. In line with that published by other authors, pregnancy does not seem to influence in any way in the evolution of the disease. Patients with Chronic Myelogenous Leukemia and Lymphoma tolerate labor quite well and almost without risk, but there is still risk of death within the first 24 hours of delivery to acute leukemia, although it has decreased to 12%. Fetal mortality is minimal for lymphomas, chronic myeloid leukemia accounts for 13% of fetal mortality and acute leukemia this is up 34%. It has not been shown that the disease is transmissible from mother to child. Chemotherapy does not affect the fetus if administered after the first trimester, and radiotherapy can be applied on selected fields away from the pelvis cases provided that adequate protection of the uterus is made.

Between 1962 and 1980, the Departments of Gynecology and Medical Oncology INEN have handled 170 cases of trophoblastic disease. All patients had clinical and / or radiographic evidence and hormonal disease activity; histopathologic evidence was obtained when the disease was accessible to biopsy. Half of the patients are in the third decade of life, and a quarter in the fourth decade; 8 percent were under 20 years old. Only 27 percent of cases were under three months of sick time; in 21 percent of cases the disease duration was more than one year. 64.7% of cases had a history of mole, and 20 percent of abortion; in 10% of cases of history was normal delivery. Only 110 patients (64.75%) showed evidence of pelvic disease admission; 35% of 110 cases found evidence of disease in the pelvis. 55% of cases presented lung metastases, and 20% vulvovaginal metastasis; intestinal metastasis, liver o...

Chemotherapy of tumors of trophoblast has been successful in several ways. From a practical standpoint, it has allowed for the first time healing a malignant tumor with the use of chemical agents, changing the poor prognosis that had chorioepithelioma less than a decade. From the point of view of tumor biology, it has provided an opportunity to study the tumor guest relations on a "grafted" neoplasia in humans. From the biochemical point of view, it has proven the importance of certain metabolites in a selective way some cancers. The epidemiology and natural history of corioncarcinoma also been studied with renewed interest after advenimento of this therapy.