Chemotherapy of tumors of trophoblast has been successful in several ways. From a practical standpoint, it has allowed for the first time healing a malignant tumor with the use of chemical agents, changing the poor prognosis that had chorioepithelioma less than a decade. From the point of view of tumor biology, it has provided an opportunity to study the tumor guest relations on a "grafted" neoplasia in humans. From the biochemical point of view, it has proven the importance of certain metabolites in a selective way some cancers. The epidemiology and natural history of corioncarcinoma also been studied with renewed interest after advenimento of this therapy.

Chemotherapy of tumors of trophoblast has been successful in several ways. From a practical standpoint, it has allowed for the first time healing a malignant tumor with the use of chemical agents, changing the poor prognosis that had chorioepithelioma less than a decade. From the point of view of tumor biology, it has provided an opportunity to study the tumor guest relations on a "grafted" neoplasia in humans. From the biochemical point of view, it has proven the importance of certain metabolites in a selective way some cancers. The epidemiology and natural history of corioncarcinoma also been studied with renewed interest after advenimento of this therapy.