OBJETIVE: To determine whether there is a difference in the efficacy and tolerance of sublingual misoprostol and oxytocin intramuscularly in the prevention of postpartum hemorrhage. DESIGN: randomized clinical trial conducted in the "Sergio E. Benales" de Lima Hospital, during the period from January to October 2003. MATERIALS AND METHODS: The sample consisted of 136 women in labor divided into two groups: group 1, 68 patients were administered 2OOμg misoprostol sublingually and group II, 68 patients were injected with 10 IU oxytocin intramuscularly immediately after expulsion. RESULTS: In the misoprostol group, the average birth and postpartum bleeding time was 18 min 2 sec 486.6 mL; respectively, while the oxytocin 1O min 53 s and 317.12 mL on average, respectively, with statistically significant differences. significant decrease in the average hematocrit value was found before and a...

About 1 in 10 women will present an adnexal tumor in her life and most will require surgical evaluation to rule out a malignant nature considering that risk of malignancy increases with age. Objective: To determine the frequency and malignancy of adnexal tumors by age, location and malignancy. Design: Descriptive, cross-sectional study. Setting: Ginecology and Gynecologic Oncology Services, Hospital Nacional Arzobispo Loayza, Lima, Peru. Material: Histopathology registries. Methods: Review of histopathology results of 876 patients who had surgery in 2013-2014 for adnexal tumor, that included anexectomies, oophorectomies, hysterectomies with adnexectomy and both paratubarian and paraovaric tumors. Main outcome measures: Tumor frequencies, localization and malignancy. Results: Out of 876 adnexal tumors, 73% were ovarian pathology, 14% tubal and 13% paratubal; 7% (61) were malignant. From t...

OBJETIVE: To compare the efficacy, tolerability and safety of nifedipine with ritodrine on the threat of preterm delivery. MATERIALS AND METHODS: Randomized clinical trial that between 1998 and 1999, studied 70 women with singleton pregnancies who were randomly distributed into 2 groups of 35 patients to be treated with ritodrine or nifedipine. PLACE: E Sergio Bernales Hospital Collique, teaching hospital. RESULTS: Time of prolongation of gestation was 13.3 ± 9.8 days for ritodrine and 16.9 ± 10.4 days for nifedipine. RN gestational age was 34.9 ± 3.8 weeks and 35.3 ± 4.1 weeks for ritodrine and nifedipine, respectively. Newborn weights were 2259 ± 805 g for ritodrine and 2392 ± 828 g for nifedipine (p = NS). 94% of patients treated with ritodrine had one or more side effects, while only 28.5% of the nifedipine group had discomfort (p = 0.00001). Were side effects of ritodrine mate...

OBJETIVE: To compare the efficacy, tolerability and safety of nifedipine with ritodrine on the threat of preterm delivery. MATERIALS AND METHODS: Randomized clinical trial that between 1998 and 1999, studied 70 women with singleton pregnancies who were randomly distributed into 2 groups of 35 patients to be treated with ritodrine or nifedipine. PLACE: E Sergio Bernales Hospital Collique, teaching hospital. RESULTS: Time of prolongation of gestation was 13.3 ± 9.8 days for ritodrine and 16.9 ± 10.4 days for nifedipine. RN gestational age was 34.9 ± 3.8 weeks and 35.3 ± 4.1 weeks for ritodrine and nifedipine, respectively. Newborn weights were 2259 ± 805 g for ritodrine and 2392 ± 828 g for nifedipine (p = NS). 94% of patients treated with ritodrine had one or more side effects, while only 28.5% of the nifedipine group had discomfort (p = 0.00001). Were side effects of ritodrine mate...

OBJETIVE: To determine whether there is a difference in the efficacy and tolerance of sublingual misoprostol and oxytocin intramuscularly in the prevention of postpartum hemorrhage. DESIGN: randomized clinical trial conducted in the "Sergio E. Benales" de Lima Hospital, during the period from January to October 2003. MATERIALS AND METHODS: The sample consisted of 136 women in labor divided into two groups: group 1, 68 patients were administered 2OOμg misoprostol sublingually and group II, 68 patients were injected with 10 IU oxytocin intramuscularly immediately after expulsion. RESULTS: In the misoprostol group, the average birth and postpartum bleeding time was 18 min 2 sec 486.6 mL; respectively, while the oxytocin 1O min 53 s and 317.12 mL on average, respectively, with statistically significant differences. significant decrease in the average hematocrit value was found before and a...

There is plenty of information about drug safety during pregnancy, but there is little scientific evidence on this topic. Due to ethical reasons, very scarce clinical assays have been conducted and published. This situation has resulted in the exaggeration of drug risk during pregnancy, thus limiting its reasonable use for chronic diseases in pregnant women. At the other extreme, it has resulted in the careless prescription of drugs not acknowledging the real risk involved in administering them in the inappropriate dose and moment. This review article describes how physiological changes during pregnancy modify significantly the pharmacokinetics of drugs. The real potential risk of drug-induced teratogenesis and the specific criteria for considering them an etiological factor are evaluated. The U.S. Food and Drug Administration (FDA) pregnancy categories' criteria, limitations, and limite...

El 13% de todas las muertes maternas en el mundo son por aborto. Por cada mujer que muere por aborto hay 10 ó 15 que quedan con secuelas. La clandestinidad le da al aborto características de inseguridad, explotación y deshumanización y sobre todo arroja a las mujeres mas pobres a practicarlo en condiciones insalubres que pone en riesgo su integridad física. El propósito del presente estudio es analizar los factores que contribuyen al aborto clandestino, determinar el impacto que causa su práctica en la salud pública, y analizar la situación legal en el Perú a partir de la opinión de agentes involucrados. MATERIAL Y METODOS Es un estudio prospectivo, transversal, observacional, y explicativo, realizado desde enero del 2004 a Junio del 2005. en los hospitales “Sergio E Bernales” y “A Loayza”, en consultorios particulares, en un Seminario católico y parroquias de Lima y ...

Surgical treatment of vulvar pain and dyspareunia. Practical approach of dysmenorrhea in adolescents. Vulvovaginitis in the infant and adolescent. Office rapid tests for the diagnosis of cervical and vaginal infections.