I designed and formulated a shampoo containing the alcoholic extract of Urtica urens L. using an analytical, experimental and comparative method. white rabbits, New Zealand breed males (irritation test for biological evaluation of medical devices) were used. They were part of this study diagnosed with hair loss non-pathological origin; numbering 10 people were evaluated by a medical professional, for 21 days. They were subjected to microscopic observation fallen hair daily to assess whether there is increased hair diameter compared to the beginning and end of the study. fallen hair count per day throughout the treatment was obtained. Using the method of standardized hair count by 60 seconds. They were obtained as results that the percentage of hair loss reduction was 56.8% for the group of people who used the shampoo at a concentration of 2% and 32.1% for the group of people using a sham...

It is developed and validated an analytical method for the simultaneous quantification of phenylephrine hydrochloride, Paracetamol, salicylamide, chlorpheniramine maleate and Caffeine tablets using Liquid Chromatography High Resolution reversed phase (HPLC-RP). The mobile phase consisted of phosphate buffer pH 3.5 and wavelength of 202 nm ultraviolet detector for phenylephrine hydrochloride, 298 nm for Paracetamol, Chlorpheniramine maleate to 205 nm, 262 nm for Salicylamide and Caffeine. a good chromatographic separation using a column filled L11 phenyl silica was achieved. The retention time for each analyte was 8.6 Phenylephrine hydrochloride for, for Paracetamol 17.7, 22.2 for salicylamide, caffeine and 23.7 to 31.2 Chlorpheniramine maleate for using gradient elution with acetonitrile in proportion of 20% maximum along the chromatographic run. The precision and accuracy was greater th...

Pharmaceutical equivalence in vitro four medicines containing paracetamol, maleate chlorpheniramine and phenylephrine hydrochloride tablets using Chromatography Liquid High Resolution reversed phase (HPLC-RP) is called, the dissolution profiles of the reference product and were determined 4 products in the study also were established and compared the differences in the dissolution profiles of the reference product and the products under study. The design methodology was analytical, experimental and comparative. Four formulations marketed in Lima and the reference product was evaluated by the method of high performance liquid chromatography (HPLC). the dissolution profiles were measured and were compared using a statistical method independent model difference factor (f1) and similarity (f2), which revealed that the dissolution curves are different between products reference laboratory and...

Introducción: la caída de cabello es un tema que nos tiene muy pendientes de cuántos cabellos se nos caen y cómo evitarlo. Podemos prevenir algún tipo de caída o actuar en estadios iniciales de un proceso de caída para mejorar el estado del cabello, para favorecer el crecimiento del cabello más saludable y fortalecido o contribuir en prolongar los ciclos de vida del cabello. Objetivo: Diseñar y formular el Champú conteniendo el extracto alcohólico de Urtica urens L. Diseño: analítico, experimental y comparativo. Lugar: Facultad de Farmacia y Bioquímica de la Universidad Nacional Mayor de San Marcos, Lima, Perú. Material y método: hojas de la planta. Conejos blancos, raza neozelandesa machos (Ensayo irritación para evaluación biológica de productos sanitarios). Formaron parte del presente estudio personas diagnosticadas con caída del cabello de origen no patológico, e...

Desarrolla y valida un método analítico por HPLC para la calificación de equivalencia farmacéutica in vitro de cuatro medicamentos conteniendo paracetamol, clorfenamina maleato y fenilefrina clorhidrato en tabletas. Se desarrolla y valida el método por cromatografía liquida de alta resolución. Se cuantifica perfiles de disolución y compara por método estadístico modelo independiente, factor de diferencia (f1) y de similitud (f2).

Introducción: Las clases prácticas son importantes en la formación académica del estudiante, sin embargo, se han viso limitados por factores coyunturales en el País. Las estrategias audiovisuales permiten al estudiante contar con material útil para el aprendizaje y tener la capacidad de elaborar competencias que se orienten a lograr su autonomía. Objetivos: conocer la importancia del uso de estrategias audiovisuales en el proceso de enseñanza durante el desarrollo de clases prácticas en estudiantes universitarios, para ello se analizó las ventajas, desventajas y efectividad de su aplicación, además del impacto en la retención y comprensión de los contenidos por parte de los estudiantes. Desarrollo del estudio: se realizó una investigación documentaria sobre el uso de medios audiovisuales, el aula invertida, simulaciones y laboratorios virtuales como herramientas para faci...

Objectives: To determine the chemical composition of the essential oil of Aloysia triphylla “Cedrón”, obtained from the leaves and stems by the steam entrainment method, which in turn serves as an input for the preparation of a mouthwash that can combat halitosis. Materials and methods: The plant material was collected from the city of Huaraz and dried to the environment, the extraction of the essential oil was carried out by the hydrodistillation method with steam drag at controlled temperature and pressure, it was stored in a jar of amber glass in refrigeration. The yield was determined by the volumetric gravimetric method. The determination of the chemical components was carried out by the method of gas chromatography coupled to mass spectrometry using an Agilent Technologies 7890 gas chromatograph, Agilent Technologies 5975C mass spectrometer detector, Column J&W 122-1545.67...

Objectives: to determine the antimicrobial activity of the essential oil obtained from the leaves and stems of Aloysia triphylla “Cedrón” from the city of Huaraz, department of Ancash, district of Mancos. Materials and methods: The method of hydrodistillation by dragging of Steam to obtain the essential oil and for the determination of the antibacterial activity was carried out by the agar diffusion methodology against Streptococcus mutans ATCC 25175 and Porphyromonas gingivalis ATCC 33277, comparing them with a positive control which was a commercial chlorhexidine mouthwash at 0.05%. Results: a yield of 0.11 was obtained and in the microbiological study, 21.3 mm halos of the essential oil and 19.9 mm of the positive control against Streptococcus mutans ATCC 25175 and 35.5 mm in the essential oil were obtained. and 25.4 mm of the positive control against Porphyromonas gingivalis ATC...

Objective: To evaluate the repairing effect of a Carica papaya L peel-based shampoo. Materials and methods: The peels were dehydrated by lyophilization, once stabilized it was stored and a shampoo could be formulated to test its repairing effect. The fatty acid components present were analyzed by gas chromatography coupled to mass spectrometry. The skin irritation and sensitization test of the shampoo was carried out in rabbits. The repairing effect was evaluated using the methodology of scanning electron microscopy evaluating samples of virgin hair subjected to different aggressions, such as permanent staining and bleaching, which in turn were subjected to treatments with Carica papaya L. rind shampoo at concentrations of 1% and 3% compared to base shampoo and a commercial shampoo. Results: In the determination of fatty acids of the shell, it was obtained that it contains 27.86% of lino...

Objetivos: Determinar la bioexención de dos medicamentos multifuentes (genéricos) conteniendo Ácido acetilsalicílico 100 mg en tabletas. Materiales y métodos: Estudio descriptivo comparativo con determinación de parámetros estadísticos que reflejaron la validez, la objetividad y confiabilidad de la metodología analítica. Se utilizaron dos productos multifuente dispensados en establecimientos farmacéuticos en Lima y el producto de referencia. Los perfiles de disolución fueron cuantificados por la técnica por Espectrofotometría ultravioleta-visible Estos perfiles se evaluaron realizando un análisis de modelo independiente que se basó en la determinación del factor de similitud (f2). Se establecieron los perfiles de disolución efectuados en medios a pH fisiológicos según lo establecido por la OMS (Reporte Técnico 937). Para determinar la equivalencia terapéutica se uti...