Objective. To determine the frequency of infection by Helicobacter pylori (HP) and premalignant gastric lesions (PGL) in patients with non-studied dyspepsia, in a general hospitalin Lima. Material and methods. It was carried out a descriptive, cross-sectional, retrospective study. The study population corresponded to outpatients referred to the Hospital EsSalud Uldarico Rocca Fernandez, Villa El Salvador, Lima, with a diagnosis of non-studied dyspepsia, who underwent upper gastrointestinal endoscopy between April 2012 and March 2014. Clinical and anatomopathological characteristics were evaluated. Results. 2 790 patients were studied, average age 48,6 (SD ± 15,3) year-old, range: 14-91 year-old. We found a global frequency of HP infection in 61,3 % (95%CI: 59,5-63,1) and premalignant gastric lesions in 23,6 % (95%CI: 22-25,1). A statistically significant association was found between pa...

Objective. To determine the frequency of infection by Helicobacter pylori (HP) and premalignant gastric lesions (PGL) in patients with non-studied dyspepsia, in a general hospitalin Lima. Material and methods. It was carried out a descriptive, cross-sectional, retrospective study. The study population corresponded to outpatients referred to the Hospital EsSalud Uldarico Rocca Fernandez, Villa El Salvador, Lima, with a diagnosis of non-studied dyspepsia, who underwent upper gastrointestinal endoscopy between April 2012 and March 2014. Clinical and anatomopathological characteristics were evaluated. Results. 2 790 patients were studied, average age 48,6 (SD ± 15,3) year-old, range: 14-91 year-old. We found a global frequency of HP infection in 61,3 % (95%CI: 59,5-63,1) and premalignant gastric lesions in 23,6 % (95%CI: 22-25,1). A statistically significant association was found between pa...

 Objective: To determine if the eradication rate of Helicobacter pylori with first line triple therapy for 14 days is better than with 10 days. Material and methods: Retrospective cohort study. It was reviewed medical records of the patients with dyspepsia and upper digestive endoscopy with a positive H. pylori biopsy, who received triple therapy with amoxicillin, clarithromycin and omeprazole for 10 or 14 days. Eradication was defined by the 13C-UBT breath test, 4 to 6 weeks after treatment. Results: It was evaluated 381 patients, 207 received treatment for 10 days and 174 for 14 days. The average age was 49 ± 13.9(15 to 82) years. The female sex was predominating (69,8%). The eradication rate of H. pylori in the 10-day and 14-day treatment group was 79, 7% and 82, 2% respectively (risk ratio, 1.03; 95% confidence interval, 0.94-1.14; p=0,541). Adverse events were reported in 75,1...

 Objective: To determine if the eradication rate of Helicobacter pylori with first line triple therapy for 14 days is better than with 10 days. Material and methods: Retrospective cohort study. It was reviewed medical records of the patients with dyspepsia and upper digestive endoscopy with a positive H. pylori biopsy, who received triple therapy with amoxicillin, clarithromycin and omeprazole for 10 or 14 days. Eradication was defined by the 13C-UBT breath test, 4 to 6 weeks after treatment. Results: It was evaluated 381 patients, 207 received treatment for 10 days and 174 for 14 days. The average age was 49 ± 13.9(15 to 82) years. The female sex was predominating (69,8%). The eradication rate of H. pylori in the 10-day and 14-day treatment group was 79, 7% and 82, 2% respectively (risk ratio, 1.03; 95% confidence interval, 0.94-1.14; p=0,541). Adverse events were reported in 75,1...

Objetivo: Determinar la validez diagnóstica de una prueba de amonio en aire espirado para la infección por Helicobacter pylori en pacientes a los que se le realiza una endoscopía digestiva alta en el Hospital Cayetano Heredia. Material y métodos: De abril a diciembre del 2014 se evaluó a 155 pacientes con una prueba de amonio en aliento y la evaluación histopatológica de las biopsias de estómago (considerada como el patrón de oro) tomadas durante la endoscopía. Los datos fueron analizados en Microsoft Excel y STATA 14 para construir una curva ROC. Resultados: Los pacientes fueron predominantemente mujeres (71%), con una edad media de 53 años (18-84) y una prevalencia de Helicobacter pylori de 51,6%. Al comparar la prueba de amonio en aire espirado con la prueba histológica se obtiene una sensibilidad de 70%, especificidad de 36%, valor predictivo positivo de 53,8%, valor pred...

Objetivo: determinar el grado de asociación de los genes IRF-5 y HLA-DRB1 en pacientes lúpicas con compromiso renal. Materiales y Métodos: Estudio transversal comparativo. Se evaluaron 109 pacientes con diagnóstico de LES, (según criterios de ACR-2012), que acudieron al servicio de Reumatología del Hospital Cayetano Heredia (HCH) de enero 2018 a enero 2020. Se evaluó el compromiso renal con los scores de SLEDAI-2K, SLICC 2012. el tipaje molecular HLA DRB1 de alta resolución por PCR (SSO), con la plataforma LUMINEX®, y la técnica de secuenciamiento de Sanger (SBT) para identificar polimorfismos de un solo nucleótido (SNP) del gen factor regulador de interferón - 5(IRF-5) para los dos SNPs rs2004640 G/T y rs60344245 ins/del 30pb. Resultados: 61 pacientes diagnosticados LES con compromiso renal (LES-R) y 48 sin compromiso renal (LES-NR), comparados con 72 donantes renales (sanos...