The indiscriminate use of antimicrobials (bactericidal, antifungals, or antivirals), used prophylactically in food or therapeutically in the poultry industry, has caused growing concern about the antimicrobial resistance of many microorganisms, endangering the effectiveness of prevention and the treatment of certain infections. Therefore, several production industries, including the poultry industry, are choosing to replace these commercial antimicrobials with natural antimicrobial agents that come from medicinal plants, evaluating the effects of their extracts or these secondary metabolites. Therefore, the study aimed to evaluate the antimicrobial activity (bactericidal and antifungal) from a natural formulation of cimenol-citric acid ring (ACAC) against experimentally contaminated corn with Pseudomonas sp, Clostridium sp, Escherichia coli, Salmonella sp, Fusarium sp, Rhizopus sp and As...

Cardiovascular diseases (CVDs), including atherosclerosis, are globally the leading cause of death. Key factors contributing to onset and progression of atherosclerosis include the pro-inflammatory cytokines Interferon (IFN)α and IFNγ and the Pattern Recognition Receptor (PRR) Toll-like receptor 4 (TLR4). Together, they trigger activation of Signal Transducer and Activator of Transcription (STAT)s. Searches for compounds targeting the pTyr-SH2 interaction area of STAT3, yielded many small molecules, including STATTIC and STX-0119. However, many of these inhibitors do not seem STAT3-specific. We hypothesized that multi-STAT-inhibitors that simultaneously block STAT1, STAT2, and STAT3 activity and pro-inflammatory target gene expression may be a promising strategy to treat CVDs. Using comparative in silico docking of multiple STAT-SH2 models on multi-million compound libraries, we identi...