This study analyzes various macroeconomic factors related to trade openness that influence Total Factor Productivity (TFP) from 2000 to 2019 in a global comparative perspective between the developed countries of Asia and Europe and the developing countries of America. Latin. The econometric method used is Feasible Generalized Least Squares for a sample of 16 countries from each mentioned group. The results indicate that, for advanced economies, manufacturing exports, input imports and Foreign Direct Investment have a positive and significant effect on TFP, while for developing economies only exports of manufactured goods and Foreign Direct Investment have a positive and significant effect. The rest of the variables were negative or not significant. Therefore, we believe that a change in Latin American trade policy is necessary to make better use of the benefits of trade liberalization on...