Antecedentes: La leishmaniasis cutánea (LC) es una enfermedad infecciosa endémica en Perú. En áreas rurales es común la manipulación de las lesiones y el uso de tratamientos tradicionales como primera opción terapéutica. Lamentablemente, se desconoce la frecuencia y efectos de la manipulación en hospitales de referencia. Se seleccionó el Programa de Leishmaniasis del Hospital Cayetano Heredia, Lima. Objetivo: Describir la prevalencia y potenciales efectos de la manipulación de lesiones de LC en un hospital de referencia. Material y métodos: Se realizó un estudio observacional descriptivo, retrospectivo (serie de casos), utilizando registros clínicos de pacientes que acudieron al Programa de Leishmaniasis del Hospital Cayetano Heredia, centro de referencia nacional, durante junio – diciembre 2017. Resultados: Se trabajó con 124 pacientes con LC de los cuales el 54% (67/12...

Immunohistochemistry (IH) allows to classify breast cancer in subtypes that are relevant for treatment and prognosis. Compared to genetic markers, IH is cheaper, easier to perform and has good correlation with molecular subtypes. Objective: To describe the immune phenotypic profile of patients with breast cancer attended at a public hospital in Lima, Peru. Methods: Cross-sectional study that included all cases of invasive breast cancer diagnosed from May 1st 2015 to April 30, 2017. Histopathological description was performed and cases were classified based on current protocols into four subtypes. Results: 330 cases were included; 71 were excluded; 259 were left for analysis. Mean age was 54.64 ± 14.07 years. In half of cases the cancer was located in the right breast. The invasive ductal carcinoma accounted for 88.03% of cases; the intermediate histological degree was found in 53.28% of...

Objective:To compare the efficacy and safety of sodium stibogluconate (SS) and meglumine antimoniate (MA) in the treatment of cutaneous leishmaniasis (CL) in a general hospital.Methods: Case-series of 193 patients with CL treated in three clinical trials with MA (n=69) and SS (n=124) during 2001-2010. Both study drugs were administered intravenously at a slow speed at 20 mg Sb5+/kg/day for 20 consecutive days following WHO-PAHO recommendations. Clinical and safety data were gathered from clinical files. Results: Demographic characteristics were similar between the study groups, but the size and number of lesions were higher in the MA group. Efficacy was 76.0% in the MA vs. 68.4% in the SS group (p=0.340) and 55.1% vs. 50.8% (p=0.570) in the per protocol and intention to treat analysis. respectively. Side effects more frequently reported were dysgeusia (37.0%). dizziness (32.0%). headache...