The objective of this study was to determine the effect of hypoxia on iron stores comparing two groups of healthy and sedentary child-bearing women: one group was based in Lima at sea level (100-150 m) and the other included women living in Cerro de Pasco (4,338 m). The study subjects were women aged15 to 30 years old, with no risk factors for iron deficiency. They were randomly selected following these steps: 1. Filling a screening form; 2. Having a medical examination performed, also looking for risk factors that may modify serum ferritin levels; 3.Taking blood samples for measuring Hemoglobin (Hb), Hematocrit, and serum ferritin. Steps 1 and 2 allowed us to exclude women with excessive blood loss or those presenting with conditions that may modify iron metabolism. There were no significant differences with respect to age, but there were some differences in hematological parameters, su...

The objective of this study was to determine the effect of hypoxia on iron stores comparing two groups of healthy and sedentary child-bearing women: one group was based in Lima at sea level (100-150 m) and the other included women living in Cerro de Pasco (4,338 m). The study subjects were women aged15 to 30 years old, with no risk factors for iron deficiency. They were randomly selected following these steps: 1. Filling a screening form; 2. Having a medical examination performed, also looking for risk factors that may modify serum ferritin levels; 3.Taking blood samples for measuring Hemoglobin (Hb), Hematocrit, and serum ferritin. Steps 1 and 2 allowed us to exclude women with excessive blood loss or those presenting with conditions that may modify iron metabolism. There were no significant differences with respect to age, but there were some differences in hematological parameters, su...

Objetivo: Determinar el efecto que ejerce la administración de hierro hemo y la de sulfato ferroso con vitamina C en hígado y cerebro de rata. Materiales y métodos: Se utilizaron ratas albinas Holtzman mantenidas en un bioterio con temperatura de 22 ± 2° C, humedad entre 50 y 70 % y 12 horas de luz y 12 horas de oscuridad, que recibieron 4,0 mg de hierro elemental/ kg p.c. bajo la forma de hierro hemo o como sulfato ferroso + 10 mg de vitamina C durante siete días, a cuyo término se sacrificaron y se les extrajo sangre, hígado y cerebro. Se hicieron los cortes histológicos que se trataron con hematoxilina-eosina para la observación microscópica y en el suero se midió la capacidad antioxidante. Resultados: Los cerebros de las ratas que recibieron tratamiento con hierro hemo y sulfato ferroso + vitamina C no sufrieron alteraciones significativas, mientras que los cortes histolÃ...

Objective: To determine the effect exerted by the administration of heme iron and ferrous sulfate with vitamin C in rat liver and brain. Materials and methods: The study used Holtzman albino rats housed in a bioterium with a temperature of 22 ± 2 °C, humidity between 50 and 70 %, and 12 hours of light and 12 hours of darkness. They received elemental iron 4.0 mg/kg b.w. as heme iron or ferrous sulfate + vitamin C 10 mg for seven days, at which time they were sacrificed, and blood, liver and brain were extracted. Histological sections were made and treated with hematoxylin-eosin for microscopic observation, and serum antioxidant capacity was measured. Results: The brains of the rats treated with heme iron and ferrous sulfate + vitamin C did not undergo significant changes, while the histological sections of the livers of the rats treated with heme iron showed a parenchyma without polar ...

Objetivo: Determinar el efecto que ejerce la administración de hierro hemo y la de sulfato ferroso con vitamina C en hígado y cerebro de rata. Materiales y métodos: Se utilizaron ratas albinas Holtzman mantenidas en un bioterio con temperatura de 22 ± 2° C, humedad entre 50 y 70 % y 12 horas de luz y 12 horas de oscuridad, que recibieron 4,0 mg de hierro elemental/ kg p.c. bajo la forma de hierro hemo o como sulfato ferroso + 10 mg de vitamina C durante siete días, a cuyo término se sacrificaron y se les extrajo sangre, hígado y cerebro. Se hicieron los cortes histológicos que se trataron con hematoxilina-eosina para la observación microscópica y en el suero se midió la capacidad antioxidante. Resultados: Los cerebros de las ratas que recibieron tratamiento con hierro hemo y sulfato ferroso + vitamina C no sufrieron alteraciones significativas, mientras que los cortes histolÃ...