The purpose of this study was to assess whether the loss of fur and changes in liver enzymes, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), produced in albino mice by oral administration of carbon tetrachloride and dimethyl sulfoxide (DMSO) (1:1), 2 mL/kg dose, are reversible processes when administered modified aloe gel (GSM) orally daily dose of 8 mL/kg of weight. Tests carried out at 13, 18 and 33 days from starting treatment with GSM, was evidenced significant and progressive decrease in AST and ALT without significant variations in proteins and phosphatases; whereas triglyceride level by the effect of GSM (group B), experienced significant decrease during the first week compared to mice given CCl4+DMSO mixture (group A), specimens that also recovered the fur on its chest and muzzle at 33 days of starting the experiment. The mice in the groups: control, GSM, DM...

The purpose of this study was to assess whether the loss of fur and changes in liver enzymes, aspartate aminotransferase (AST) and alanine aminotransferase (ALT), produced in albino mice by oral administration of carbon tetrachloride and dimethyl sulfoxide (DMSO) (1:1), 2 mL/kg dose, are reversible processes when administered modified aloe gel (GSM) orally daily dose of 8 mL/kg of weight. Tests carried out at 13, 18 and 33 days from starting treatment with GSM, was evidenced significant and progressive decrease in AST and ALT without significant variations in proteins and phosphatases; whereas triglyceride level by the effect of GSM (group B), experienced significant decrease during the first week compared to mice given CCl4+DMSO mixture (group A), specimens that also recovered the fur on its chest and muzzle at 33 days of starting the experiment. The mice in the groups: control, GSM, DM...

The aim of this study was to evaluate the hepatoprotective effect of Aloe vera modified gel (MAVG) against the injury induced in albino mice by the oral administration of mixed overheated cooking oil (OCO) with dimethyl sulfoxide (DMSO) (1:1). OCO doses used were 2,3 and 3,1 mL/kg administered for 14 days, which produced increases of transaminases ALT, AST and triglycerides. For the specimens that received the lowest dose of OCO (2,3 mL/kg body weight), since day 14 and continuing for 18 days, were administered additionally four drops daily of MAVG equivalent to 6,1 ml/kg. When analyzing the results obtained at 14, 19, 28 and 33 days of starting treatment were observed significant progressive decrease in ALT, AST and triglycerides. However, the specimens that received the highest dose of OCO (3,1 ml/kg) plus MAVG, showed increase in the levels of ALT, AST and triglycerides over time, sug...

El objetivo del presente estudio fue evaluar el efecto hepatoprotector del gel de Aloe vera modificado (GAVM) frente a la injuria inducida en ratones albinos por la administración, vía oral, de aceite comestible recalentado (ACR) mezclado con dimetilsulfóxido (DMSO) (1:1). Las dosis de ACR usadas fueron 2,3 y 3,1 mL/kg, administradas por 14 días, lo cual produjo incremento de las transaminasas (ALT, AST) y triglicéridos. A los ejemplares que recibieron la menor dosis de ACR (2,3 mL/kg de peso), a partir del día 14 y por 18 días, se les suministró, adicionalmente, cuatro gotas diarias de GAVM equivalente a 6,1 mL/kg de peso. Al analizar los resultados obtenidos a los 14, 19, 28 y 33 días de iniciado el tratamiento, se observó disminución progresiva significativa de ALT, AST y triglicéridos. Sin embargo, los ejemplares que recibieron mayor dosis de ACR (3,1 mL/kg de peso) más ...